Moderate drinking tied to lower levels of Alzheimer’s brain protein (Business Standard):
“Korean researchers studied 414 men and women, average age 71, who were free of dementia or alcohol-related disorders. All underwent physical exams, tests of mental acuity, and positron emission tomography (PET) and magnetic resonance imaging (MRI) scans. They were carefully interviewed about their drinking habits.
The study, in PLOS Medicine, measured drinking in “standard drinks” — 12 ounces of beer, five ounces of wine, or one-and-a-half ounces of hard liquor. Compared with abstainers, those who drank one to 13 standard drinks a week had a 66 per cent lower rate of beta amyloid deposits in their brains.
The results applied only to those who drank moderately for decades, and not to those who recently began drinking moderately or drank more than 13 drinks a week.”
Association of moderate alcohol intake with in vivo amyloid-beta deposition in human brain: A cross-sectional study (PLOS Medicine). From the Abstract:
- Background: An emerging body of literature has indicated that moderate alcohol intake may be protective against Alzheimer disease (AD) dementia. However, little information is available regarding whether moderate alcohol intake is related to reductions in amyloid-beta (AB) deposition, or is protective via amyloid-independent mechanisms in the living human brain. Here we examined the associations of moderate alcohol intake with in vivo AD pathologies, including cerebral A? deposition, neurodegeneration of AD-signature regions, and cerebral white matter hyperintensities (WMHs) in the living human brain.
- Conclusions: In this study, we observed in middle- and old-aged individuals with neither dementia nor alcohol-related disorders that moderate lifetime alcohol intake was associated with lower cerebral AB deposition compared to a lifetime history of not drinking. Moderate lifetime alcohol intake may have a beneficial influence on AD by reducing pathological amyloid deposition rather than amyloid-independent neurodegeneration or cerebrovascular injury.
The Study in Context:
- Report: 35% of worldwide dementia cases could be prevented by modifying these 9 modifiable risk factors
- Study: Drinking up to 5–8 glasses of wine or beer a week not seen to increase dementia risk
- Solving the Brain Fitness Puzzle Is the Key to Self-Empowered Aging
- Study challenges the “seductive” amyloid hypothesis of Alzheimer’s disease (AD)
- To screen, or not to screen (for dementia), that is still the question