Sharp Brains: Brain Fitness and Cognitive Health News

Neuroplasticity, Brain Fitness and Cognitive Health News


Evidence review finds that computer-based cognitive training can significantly improve memory in patients with multiple sclerosis (MS)


Com­put­er-Based Cog­ni­tive Train­ing Improves Mem­o­ry Domains in Mul­ti­ple Scle­ro­sis (Neu­rol­o­gy Advi­sor):

Com­put­er-based cog­ni­tive train­ing may assist in improv­ing mem­o­ry in patients with mul­ti­ple scle­ro­sis (MS), accord­ing to a sys­tem­at­ic review pub­lished in Mul­ti­ple Scle­ro­sis and Relat­ed Dis­or­ders.

A total of 9 stud­ies report­ing the use of com­put­er-based cog­ni­tive train­ing in patients with MS were includ­ed in this sys­tem­at­ic review. For inclu­sion, each study was required to have report­ed both pre- and post-cog­ni­tive train­ing neu­ropsy­cho­log­i­cal assess­ment scores. In addi­tion, each study was required to include an inter­ven­tion arm and a place­bo or no-inter­ven­tion arm…The inves­ti­ga­tors not­ed that the cog­ni­tive train­ing effects may dif­fer in the vary­ing sub­types of MS, yet sub­types were not dif­fer­en­ti­at­ed in the includ­ed stud­ies. Also, stud­ies includ­ed com­put­er train­ing pro­grams that dif­fered in type, course length, and total train­ing dura­tion.”

The Study

Effi­ca­cy of com­put­er-based cog­ni­tive train­ing in neu­ropsy­cho­log­i­cal per­for­mance of patients with mul­ti­ple scle­ro­sis: A sys­tem­at­ic review and meta-analy­sis (Mul­ti­ple Scle­ro­sis and Relat­ed Dis­or­ders). From the abstract:

  • IMPORTANCE: Mul­ti­ple scle­ro­sis (MS) is a chron­ic inflam­ma­to­ry dis­ease of the cen­tral ner­vous sys­tem char­ac­ter­ized by relaps­es and a pro­gres­sive course that may lead to accu­mu­la­tion of phys­i­cal and cog­ni­tive dis­abil­i­ty. Cog­ni­tive train­ing inter­ven­tions seem to improve the cog­ni­tive per­for­mance of MS patients. The aim of the present meta-analy­sis is to quan­ti­ta­tive­ly inves­ti­gate the effect of com­put­er-based cog­ni­tive reha­bil­i­ta­tion on the neu­ropsy­cho­log­i­cal per­for­mance of patients with MS.
  • METHODS: We per­formed a sys­tem­at­ic review of the PubMed data­base to iden­ti­fy avail­able stud­ies that per­formed com­put­er-based cog­ni­tive train­ing in MS patients. Stud­ies should have report­ed pre- and post-cog­ni­tive train­ing neu­ropsy­cho­log­i­cal tests scores and includ­ed both inter­ven­tion and place­bo/no-inter­ven­tion MS groups. We ana­lyzed the effect of com­put­er-based cog­ni­tive reha­bil­i­ta­tion on indi­vid­ual neu­ropsy­cho­log­i­cal tests, on spe­cif­ic func­tion­al domains, and on over­all cog­ni­tion per­for­mance. The effect-size of cog­ni­tive train­ing pre- and post-treat­ment com­pared to placebo/ no-inter­ven­tion was esti­mat­ed using the stan­dard­ized mean dif­fer­ence (SMD). The 95% con­fi­dence inter­vals (CI) were esti­mat­ed using a Z test by com­par­ing the final val­ues. Base­line between-group dif­fer­ences in select­ed out­comes were esti­mat­ed with ANOVA.
  • RESULTS: In total, 9 stud­ies ful­filled the cri­te­ria for inclu­sion and were insert­ed in the quan­ti­ta­tive analy­sis. Com­put­er-based cog­ni­tive train­ing was found to improve the per­for­mance in the mem­o­ry domain of MS patients com­pared to con­trol inter­ven­tions (SMD, 0.22; 95% CI 0.01–0.43; p = 0.04). More­over, in the sub­group analy­sis, cog­ni­tive train­ing demon­strat­ed sig­nif­i­cant effects in Selec­tive Remind­ing Test (SRT) delay mem­o­ry (SMD, 0.58; 95% CI 0.29–0.87; p < 0.001).
  • CONCLUSIONS: The present meta-analy­sis revealed a sig­nif­i­cant effect for com­put­er-based cog­ni­tive train­ing on the per­for­mance of the mem­o­ry domain of patients with MS. This find­ing may have sig­nif­i­cant impli­ca­tions in the cur­rent treat­ment prac­tice when cog­ni­tive decline is detect­ed in MS patients.

The Study in Context

Leave a Reply...

Loading Facebook Comments ...

Leave a Reply

Categories: Cognitive Neuroscience, Health & Wellness, Technology

Tags: , , , , , , ,

About SharpBrains

As seen in The New York Times, The Wall Street Journal, BBC News, CNN, Reuters,  SharpBrains is an independent market research firm tracking how brain science can improve our health and our lives.

Search in our archives

Follow us and Engage via…

RSS Feed

Watch All Recordings Now (40+ Speakers, 12+ Hours)