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Study: Cognitive Markers or Biomarkers to manage Cognitive Health across the Lifespan?

Pre­dict­ing Alzheimer’s Dis­ease More Accu­rate Through Cog­ni­tive Changes Than Bio­mark­ers (Med­ical News):

  • Mea­sur­ing peo­ple’s changes in cog­ni­tive abil­i­ties is a bet­ter pre­dic­tor of Alzheimer’s dis­ease than changes in bio­mark­ers, researchers from the Ben­i­to Men­ni Com­plex Assis­ten­cial en Salut Men­tal, Barcelona, Spain, report­ed in Archives of Gen­er­al Psy­chi­a­try, a JAMA jour­nal.”
  • The inves­ti­ga­tors used a range of tests to assess the par­tic­i­pants’ cog­ni­tion and how well they func­tioned. Cog­ni­tion is the men­tal process of know­ing, and includes per­cep­tion, aware­ness, rea­son­ing and judg­ment. They also took cere­brospinal flu­id sam­ples from them at the begin­ning of the study and every year for two years. Par­tic­i­pants’ blood sam­ples were also tak­en when the study began — this was test­ed for genes which are linked to Alzheimer’s dis­ease. From MRI (mag­net­ic res­o­nance imag­ing) results includ­ed in the ADNI, they were able to gath­er data on the par­tic­i­pants’ cor­ti­cal thick­ness and brain vol­ume.
  • They found that cor­ti­cal thick­ness of the left mid­dle tem­po­ral lobe of the brain, as well as two mea­sures of delayed mem­o­ry in those with MCI were linked to a high­er like­li­hood of devel­op­ing Alzheimer’s dis­ease with­in 24 months.
  • Changes in func­tion­al activ­i­ty (Edi­tor’s Note: our empha­sis to high­light the need to eval­u­ate changes over time, not just one time activ­i­ty) scores seemed to show a greater rate of decline in the par­tic­i­pants than changes in bio­mark­ers.”

This is con­sis­tent with one of the most insight­ful ses­sions held dur­ing the 2011 Sharp­Brains Sum­mit, on The Role of Cog­ni­tive Health Mon­i­tor­ing Sys­tems (requires reg­is­tra­tion to view): A miss­ing piece in today’s brain health toolk­it is the capa­bil­ity to mon­i­tor a person’s cog­ni­tive per­for­mance and Cog­ni­tive Reserve across the lifes­pan. Such a sys­tem could great­ly facil­i­tate the pre­ven­tion, diag­no­sis and treat­ment of cog­ni­tive decline due to aging and dis­ease. Pol­icy, research and tech­nol­ogy strands are con­verg­ing to bet­ter define and meet this need: Which instru­ments, plat­forms and ana­lyt­i­cal approach­es could pro­vide the data and out­comes required? How will behav­ioral mark­ers com­ple­ment bio­log­i­cal and neu­roimag­ing mark­ers? How may cog­ni­tive mon­i­tor­ing sys­tems be devel­oped, mar­keted and used?

  • Dr. Yaakov Stern, Head Cog­ni­tive Neu­ro­science Divi­sion of the Taub Insti­tute, Colum­bia Uni­ver­si­ty
  • Dr. David Dar­by, Chief Med­ical Offi­cer, CogState
  • Dr. Jef­frey Kaye, Direc­tor, NIA — ORCATECH
  • Mod­er­ated by: Dr. Joshua Stein­er­man, Assis­tant Pro­fes­sor, Albert Ein­stein Col­lege of Med­i­cine

To learn more about the 2011 Sharp­Brains Sum­mit (record­ings are now avail­able): click Here.

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2 Responses

  1. Sunny Yadav says:

    This is very fine blog. I got mean­ing­ful infor­ma­tion from this study. Keep it up.

  2. john says:

    great web­site and use­ful info

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As seen in The New York Times, The Wall Street Journal, BBC News, CNN, Reuters,  SharpBrains is an independent market research firm tracking how brain science can improve our health and our lives.

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