Tracking Health and Wellness Applications of Brain Science

amyloid

Questionable “Alzheimer’s blood test” goes on sale prior to FDA approval

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First blood test to help diag­nose Alzheimer’s goes on sale (NBC News):

A com­pa­ny has start­ed sell­ing the first blood test to help diag­nose Alzheimer’s dis­ease, a leap for the field that could make it much eas­i­er for peo­ple to learn whether they have demen­tia. It also rais­es con­cern about the accu­ra­cy and impact of such life-alter­ing news. [Read more…] about Ques­tion­able “Alzheimer’s blood test” goes on sale pri­or to FDA approval

Update: Should candidates to high office should pass a cognitive/ mental fitness test?

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Wow, that was a cou­ple of very insight­ful dis­cus­sions, via social media no less.

#1. The first one was about whether heads of state and can­di­dates to high office should pass a cognitive/ men­tal fit­ness test. Click HERE to read and dis­cuss some of the sharpest com­ments, such as…

  • “I won­der what brought this up.”
  • “Def­i­nite­ly. We rou­tine­ly screen appli­cants for a wide range of jobs.”
  • “Then the bal­ance of polit­i­cal pow­er would shift towards the design­ers of those tests.”
  • “That’s what debates are for.”
  • “Yes, but prob­a­bly nobody would pass it.”
  • “No, because if we can’t judge that for our­selves, then what busi­ness do we have vot­ing at all?”

#2. The sec­ond debate cen­tered on the future of men­tal health: In ten years, will we see DSM‑6 or Some­thing Much Bet­ter (SMB‑1)? Would you say “Some­thing bet­ter hope­ful­ly” or “Well con­sid­er­ing we approach men­tal health from a dis­ease model.…that’s the first prob­lem” or “DSM is a tool, and a very use­ful one. As any oth­er tool it depends on the use you make of it,” or some­thing else.

Wel­come to a new edi­tion of Sharp­Brains’ e‑newsletter, fea­tur­ing as always new think­ing, research and tools for life­long brain health and men­tal fitness.

#3. Study: Across all ide­o­log­i­cal groups, high­er cog­ni­tive abil­i­ty and intel­lec­tu­al humil­i­ty pre­dicts sup­port for free speech

#4. Let’s under­stand how to increase resis­tance to tau and amy­loid pro­teins so we can all become “super-agers.”  Brain scans show low­er accu­mu­la­tion of tau and amy­loid pathol­o­gy among cog­ni­tive “super-agers”

#5. For exam­ple: Jobs with low phys­i­cal stress and good work­ing con­di­tions linked to larg­er hip­pocam­pus and bet­ter memory

#6. Want­ed: 30,000 vol­un­teers! Large UC study to inves­ti­gate when and how brain train­ing trans­fers (or does not) to broad­er cog­ni­tive and health benefits

#7. Time­ly ques­tions: “How com­mon are neu­ro­log­i­cal and psy­chi­atric com­pli­ca­tions in patients with COVID-19? What pro­por­tion of neu­ro­log­i­cal and psy­chi­atric com­pli­ca­tions affect the (cen­tral ner­vous sys­tem) ver­sus the periph­er­al ner­vous sys­tem, and are nov­el syn­dromes emerg­ing? And who is most at risk?” Sur­vey finds ischaemic stroke and altered men­tal sta­tus as most com­mon neu­ro­log­i­cal com­pli­ca­tions in severe COVID-19 cases

#8. “Our mind is one of the only things that we can­not con­sis­tent­ly mea­sure and quan­ti­fy. And humans do remark­able things when we can mea­sure some­thing.”  Ker­nel rais­es $53 mil­lion to ease access to rich neur­al data and mar­ket Neu­ro­science as a Ser­vice (NaaS)

#9. “We are tak­ing proven cog­ni­tive behav­ioral ther­a­pies and ful­ly automat­ing them to deliv­er the care scal­ably and con­sis­tent­ly as drugs.” Start­up Big Health rais­es $39M to uni­ver­sal­ize access to cog­ni­tive behav­ioral ther­a­py (CBT) for anx­i­ety and poor sleep

#10. Build­ing on Bill Gates’ orig­i­nal goal of ‘a com­put­er on every desk,’ per­haps it’s time for ‘real-time men­tal health sup­port on every phone.’ Microsoft announces sup­port for three inno­v­a­tive men­tal health ser­vices har­ness­ing arti­fi­cial intel­li­gence (AI)

#11. Res­o­nance. Empa­thy. Aware­ness. Com­pas­sion. Hope. And our favorite… Humor. Six tips to help reg­u­late stress lev­els in our organizations

#12. Final­ly, a fun brain teas­er. What do you see, rec­tan­gles or cir­cles?

 

Wish­ing you a good and safe August,

The Sharp­Brains Team

Brain scans show lower accumulation of tau and amyloid pathology among cognitive “super-agers”

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– Tau (blue) and amy­loid (orange) dis­tri­b­u­tion pat­terns for super-agers, nor­mal-agers and MCI patients, when com­pared to a group of younger, healthy, cog­ni­tive­ly nor­mal, amy­loid-neg­a­tive indi­vid­u­als. Cred­it: Mer­le C. Hoenig.

Super-Agers Show Resis­tance to Tau and Amy­loid Accu­mu­la­tion, Main­tain High Cog­ni­tive Func­tion (Soci­ety of Nuclear Med­i­cine and Mol­e­c­u­lar Imag­ing press release):

Super-agers, or indi­vid­u­als whose cog­ni­tive skills are above the norm even at an advanced age, have been found to have increased resis­tance to tau and amy­loid pro­teins, accord­ing to research pre­sent­ed at the Soci­ety of Nuclear Med­i­cine and Mol­e­c­u­lar Imag­ing (SNMMI) 2020 Annu­al Meet­ing. An analy­sis of positron emis­sion tomog­ra­phy (PET) scans has shown that com­pared to nor­mal-agers and those with mild cog­ni­tive impair­ment, super-agers have a low­er bur­den of tau and amy­loid pathol­o­gy asso­ci­at­ed with neu­rode­gen­er­a­tion, which prob­a­bly allows them to main­tain their cog­ni­tive per­for­mance. An image show­ing the com­par­i­son of tau and amy­loid dis­tri­b­u­tion pat­terns in these dif­fer­ent cog­ni­tive aging tra­jec­to­ries has been select­ed as SNMMI’s 2020 Image of the Year. [Read more…] about Brain scans show low­er accu­mu­la­tion of tau and amy­loid pathol­o­gy among cog­ni­tive “super-agers”

Update: A brain-friendly lifestyle is the best approach to delay cognitive decline and dementia

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While the hip­pocam­pus tends to shrink with age, which con­tributes to cog­ni­tive decline, a recent study shows that this is not always the case (see all those blue lines), sug­gest­ing it can be pos­si­ble to main­tain hip­pocam­pus vol­ume and cog­ni­tive func­tion into our lat­er years.

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Time to wrap-up anoth­er stim­u­lat­ing month with Sharp­Brains’ e‑newsletter, fea­tur­ing this time a range of promis­ing news for every­one with a (human) brain 🙂

New tech for brain health:

New brain and mind research:

New thinking to shape education and healthcare:

Finally, a few riddles to tease your brain:

 

Have a great Thanks­giv­ing and December,

The Sharp­Brains Team

Rethinking Alzheimer’s research, beyond amyloid deposition, via new funding models

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Alzheimer_Word_cloud_conceptHow a new approach to fund­ing Alzheimer’s research could pay off (MIT News):

“More than 5 mil­lion Amer­i­cans suf­fer from Alzheimer’s dis­ease, the afflic­tion that erodes mem­o­ry and oth­er men­tal capac­i­ties, but no drugs tar­get­ing the dis­ease have been approved by the U.S. Food and Drug Admin­is­tra­tion since 2003…Lo and three co-authors pro­pose [Read more…] about Rethink­ing Alzheimer’s research, beyond amy­loid depo­si­tion, via new fund­ing models

Questioning brain health status quo in depression and Alzheimer’s

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mentalhealthpuzzleTwo good recent pieces in The New York Times bring to the fore­front the need to ques­tion sta­tus quo mind­set and prac­tices about how to mea­sure and enhance brain health.

Sleep Ther­a­py Seen as an Aid for Depression