“Taking vitamin B12 and folic acid supplements does not seem to cut the risk of developing dementia in healthy people, say Dutch researchers. In one of the largest studies to date, there was no difference in memory test scores between those who had taken the supplements for two years and those who were given a placebo…
Dr Eric Karran, director of research at Alzheimer’s Research UK, said: “This large trial adds to previous evidence suggesting that while vitamin B supplements can lower homocysteine levels, this does not translate into improved memory and thinking in the general older population.”
Study: Results of 2‑year vitamin B treatment on cognitive performance (Neurology). From the abstract:
- Objective: We investigated the effects of 2‑year folic acid and vitamin B12 supplementation on cognitive performance in elderly people with elevated homocysteine (Hcy) levels.
- Conclusions: Two-year folic acid and vitamin B12 supplementation did not beneficially affect performance on 4 cognitive domains in elderly people with elevated Hcy levels. It may slightly slow the rate of decline of global cognition, but the reported small difference may be attributable to chance.
- Classification of evidence: This study provides Class I evidence that 2‑year supplementation with folic acid and vitamin B12 in hyperhomocysteinemic elderly people does not affect cognitive performance.