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Brain Damage, Therapeutics and the Blood-Brain Barrier

Blood-Brain Bar­ri­er Less Per­me­able in New­borns than Adults after Acute Stroke (press release):

The blood-brain bar­ri­er is selec­tive­ly per­me­able and blocks unwant­ed mol­e­cules from enter­ing into the brain. The selec­tiv­i­ty is achieved through fine coor­di­na­tion in func­tion of many trans­port­ing sys­tems in endothe­lial cells, which line the inte­ri­or of blood ves­sels, and com­mu­ni­ca­tion between endothe­lial cells and sev­er­al types of cells in the brain. When blood flow in an artery to the brain is blocked by a blood clot, as occurs in arte­r­i­al stroke, brain ener­gy metab­o­lism is com­pro­mised, and ion and oth­er trans­port­ing sys­tems mal­func­tion, lead­ing to blood-brain disruption.…The new find­ing sug­gests, the researchers said, that drugs used to treat stroke need to be tai­lored to the spe­cif­ic make­up of the neonate blood-brain barrier…“This study is a very crit­i­cal step towards devel­op­ing ther­a­peu­tics, but these find­ings are a tip of the ice­berg and a lot is still to be learned,” said Vexler. “We’re mov­ing to char­ac­ter­ize the poten­tial for neona­tal repair. Some brain dam­age can’t be diag­nosed ear­ly, but might show up lat­er. Now we are exper­i­ment­ing with post­pon­ing cer­tain treat­ments or tweak­ing some sig­nal­ing mech­a­nisms to see if we can enhance the capac­i­ty of the imma­ture brain to repair itself.”

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Categories: Cognitive Neuroscience

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As seen in The New York Times, The Wall Street Journal, BBC News, CNN, Reuters,  SharpBrains is an independent market research firm tracking how brain science can improve our health and our lives.

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