Tracking Health and Wellness Applications of Brain Science

JAMA

Study: High Cognitive Reserve (CR) seen to significantly lower dementia risk even in the presence of high Alzheimer’s Disease (AD) neuropathology

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Fig­ure 2. Inci­dence Rates of Demen­tia per 1000 Per­son-Years by Cog­ni­tive Reserve (CR) Ter­tile and Brain Pathol­o­gy; adjust­ed for age, sex, smok­ing, alco­hol con­sump­tion, phys­i­cal activ­i­ty, body mass index, heart dis­ease, hyper­ten­sion, cere­brovas­cu­lar dis­ease, dia­betes, and apolipopro­tein E e4. AD indi­cates Alzheimer dis­ease. Source: Xu H et al (2020)

Lifes­pan Cog­ni­tive Reserve—A Secret to Cop­ing With Neu­rode­gen­er­a­tive Pathol­o­gy (JAMA Neu­rol­o­gy edi­to­r­i­al):

Giv­en the lim­it­ed suc­cess of ther­a­peu­tic inter­ven­tions for Alzheimer dis­ease, there is increased inter­est in under­stand­ing whether mod­i­fi­able fac­tors can help cope with or post­pone the appear­ance of brain pathol­o­gy. It is esti­mat­ed that about 35% of Alzheimer risk is mod­i­fi­able. Epi­demi­o­log­ic stud­ies have shown that life­time expo­sures to high­er edu­ca­tion, high­er occu­pa­tion­al attain­ment, and cog­ni­tive­ly stim­u­lat­ing activ­i­ties are asso­ci­at­ed with reduced risk of Alzheimer demen­tia. Autop­sy stud­ies have shown interindi­vid­ual dif­fer­ences in the amount of brain pathol­o­gy peo­ple can tol­er­ate before man­i­fest­ing cog­ni­tive impair­ments, and autop­sied brains of about one-third of indi­vid­u­als who are cog­ni­tive­ly nor­mal meet neu­ropatho­log­i­cal cri­te­ria for Alzheimer dis­ease. [Read more…] about Study: High Cog­ni­tive Reserve (CR) seen to sig­nif­i­cant­ly low­er demen­tia risk even in the pres­ence of high Alzheimer’s Dis­ease (AD) neu­ropathol­o­gy

To screen, or not to screen (for dementia), that is still the question

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A lead­ing group of med­ical experts on Tues­day declined to endorse cog­ni­tive screen­ing for old­er adults, fuel­ing a debate that has sim­mered for years.

The U.S. Pre­ven­tive Ser­vices Task Force said it could nei­ther rec­om­mend nor oppose cog­ni­tive screen­ing, cit­ing insuf­fi­cient sci­en­tif­ic evi­dence of the practice’s ben­e­fits and harms and call­ing for fur­ther stud­ies.

The task force’s work informs poli­cies set by Medicare and pri­vate insur­ers. Its rec­om­men­da­tions, an accom­pa­ny­ing sci­en­tif­ic state­ment and two edi­to­ri­als were pub­lished Tues­day in the Jour­nal of the Amer­i­can Med­ical Asso­ci­a­tion.

The task force’s new posi­tion comes as con­cern mounts over a ris­ing tide of old­er adults with Alzheimer’s dis­ease and [Read more…] about To screen, or not to screen (for demen­tia), that is still the ques­tion

New studies reinforce Education and Cognitive Reserve –instead of drugs targeting beta amyloid– as most promising avenue to prolong cognitive health and reduce dementia risk

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dementia-progressionDemen­tia Risk Declines, And Edu­ca­tion May Be One Rea­son Why (NPR):

“Some encour­ag­ing news in the bat­tle against Alzheimer’s dis­ease and oth­er forms of demen­tia: The rate at which old­er Amer­i­cans are get­ting these con­di­tions is declin­ing. That’s accord­ing to [Read more…] about New stud­ies rein­force Edu­ca­tion and Cog­ni­tive Reserve –instead of drugs tar­get­ing beta amy­loid– as most promis­ing avenue to pro­long cog­ni­tive health and reduce demen­tia risk

Study points to growing cognitive gap between high-volume TV watchers and infrequent watchers

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watching tv adultToo Much TV And Chill Could Reduce Brain Pow­er Over Time (NPR):

“Researchers at the Uni­ver­si­ty of Cal­i­for­nia, San Fran­cis­co checked in with 3,247 peo­ple for 25 years, start­ing when they were young adults…People who got lit­tle exer­cise or watched at least three hours of TV a day did worse [Read more…] about Study points to grow­ing cog­ni­tive gap between high-vol­ume TV watch­ers and infre­quent watch­ers

Study: To improve memory and thinking skills, try the Mediterranean diet with added olive oil and nuts

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Mediterranean-Diet

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Mediter­ranean diet may help coun­ter­act age-relat­ed declines in mem­o­ry and think­ing skills (Har­vard Health Blog):

“A new study in this week’s JAMA Inter­nal Med­i­cine sug­gests that eat­ing a Mediter­ranean-style diet enhanced with extra-vir­gin olive oil or nuts is good for your mind as well as your heart. [Read more…] about Study: To improve mem­o­ry and think­ing skills, try the Mediter­ranean diet with added olive oil and nuts

Study: Cognitive Markers or Biomarkers to manage Cognitive Health across the Lifespan?

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Pre­dict­ing Alzheimer’s Dis­ease More Accu­rate Through Cog­ni­tive Changes Than Bio­mark­ers (Med­ical News):