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Deep learning model built on neuroimaging data identifies “Brain Age Gaps” as markers of Alzheimer’s disease (AD)

May 19, 2022 by SharpBrains Leave a Comment

Brain Age Gap is a Com­pos­ite Bio­mark­er for Demen­tia Pathol­o­gy or Sever­i­ty (GEN):

Mayo Clin­ic sci­en­tists have devel­oped a com­pu­ta­tion­al mod­el that pre­dicts brain age using a large col­lec­tion of neu­roimag­ing data obtained using FDG-PET (flu­o­rodeoxyglu­cose positron emis­sion tomog­ra­phy) and struc­tur­al MRI (mag­net­ic res­o­nance imag­ing). The deep learn­ing-based mod­el tests the rela­tion­ship between brain age gaps in var­i­ous forms of demen­tia, includ­ing mild cog­ni­tive impair­ment (MCI), Alzheimer’s dis­ease (AD), fron­totem­po­ral demen­tia (FTD), and Lewy body demen­tia (LBD), as well as in nor­mal brains.

[Read more…] about Deep learn­ing mod­el built on neu­roimag­ing data iden­ti­fies “Brain Age Gaps” as mark­ers of Alzheimer’s dis­ease (AD)

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Filed Under: Brain/ Mental Health, Technology & Innovation Tagged With: AD, AD biomarker, Alzheimer’s Disease, brain-aging, Cognitive-impairment, deep learning, disease, frontotemporal dementia, Lewy body dementia, mild-cognitive-impairment, neurodegenerative, neurodegenerative disease

Jan Samzelius, CEO of Brainnovations Winner NeuraMetrix, encourages pioneers to focus on “simple, elegant solutions to big problems”

January 9, 2018 by Alvaro Fernandez

What sur­prised you the most from the Judges’ ques­tions and feed­back dur­ing the Brain­no­va­tions Pitch Con­test last month?

Even with only a brief pre­sen­ta­tion the judges imme­di­ate­ly got the poten­tial impact of our tech­nol­o­gy to mea­sure and mon­i­tor brain health and began to think about oth­er appli­ca­tions for us – sev­er­al we had not thought about. That was fun.

In a nut­shell, what is the core idea behind Neu­raMetrix?

Typ­ing Cadence is among the strongest habit we have. If the brain is attacked by a dis­ease, the habit will begin to break – very slow­ly and in very small incre­ments. Our way of mea­sur­ing is so sen­si­tive that we can pick up changes at the lev­el of 1/100th of sec­ond – many orders of mag­ni­tude bet­ter than today’s tools.

When and how did the idea come to you?

Com­ing from data secu­ri­ty, our first idea was to use typ­ing cadence for authen­ti­ca­tion, and then were alert­ed to the brain health appli­ca­tion by an out­sider. [Read more…] about Jan Samzelius, CEO of Brain­no­va­tions Win­ner Neu­raMetrix, encour­ages pio­neers to focus on “sim­ple, ele­gant solu­tions to big problems”

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Filed Under: Brain/ Mental Health, Technology & Innovation Tagged With: Alzheimer’s Disease, biotech, brain diseases, brain health application, Brain-health, Brainnovations, CNS, CNS diseases, depression, diagnostics, disease, disease management, drug trials, early diagnostics, medication, NeuraMetrix, Parkinsons, precision medicine, psychiatric disorders, Typing Cadence

Update: The Neurotech Revolution Could Lead To ‘Frankenstein’ Brains. Here’s How We Avoid It

August 31, 2017 by SharpBrains

__________

Time for Sharp­Brains’ August e‑newsletter, this time start­ing with a con­ver­sa­tion whose time has come…

New thinking:

Year 2030, your col­lege-age daugh­ter, who has nor­mal hear­ing, has been pound­ing on you to get the lat­est hear­ing aid that allows one to can­cel out noise on demand, ampli­fy select­ed ambi­ent con­ver­sa­tions at will, and can eas­i­ly con­nect to the music store. Should you buy one for her? Maybe you should buy one not only for her, but also for you as you enter your 60s? Keep read­ing The Neu­rotech Rev­o­lu­tion Could Lead To ‘Franken­stein’ Brains. Here’s How We Avoid It

  • Exec­u­tive Func­tions in Health and Disease
  • Why we need “low-cost mon­i­tor­ing tech­nolo­gies to track cog­ni­tive process­es at an indi­vid­ual lev­el”, “peo­ple-cen­tered well­ness solu­tions that inte­grate brain health fac­tors” and “inter­ven­tions for healthy fetus/ baby development”
  • Would you–or should you–undergo med­ical treat­ments to improve your body and mind and your chances of employment?

New research:

  • Large study high­lights the cog­ni­tive enhance­ment val­ue of both high­er edu­ca­tion and life­long learning
  • Stud­ies rein­force the crit­i­cal impor­tance of ADHD treat­ment monitoring
  • AARP sur­vey finds most com­mon bar­ri­er for adults to add more men­tal­ly-stim­u­lat­ing activ­i­ties: Know­ing where to start
  • Opi­oid inhibitor nal­trex­one (often used to treat addic­tions) can reduce feel­ings of social connection

New tools:

  • 16 Final­ists announced @ MIT Solve’s Brain Health Challenge
  • Suzhou Insti­tute of Bio­med­ical Engi­neer­ing and Tech­nol­o­gy (SIBET) to host “brain-imag­ing factory”
  • $3 mil­lion avail­able for inno­v­a­tive solu­tions aimed at old­er adults via The Cen­tre for Aging + Brain Health Inno­va­tion (CABHI)
  • The Nation­al Sci­ence Foun­da­tion (NSF) funds Neu­rotech­nol­o­gy Hubs
  • Brainy Inno­va­tion Tips from Edward Kli­phuis, Invest­ment Direc­tor with Mer­ck Ventures

Upcoming events (and discount codes):

  • Sep­tem­ber 6–7th, Wash­ing­ton, DC: Brain­Fu­tures and The Future of Brain Health and Enhance­ment (“sharp­brains” = $100 off)
  • Octo­ber 19–22nd, Los Ange­les: Brain Longevi­ty Ther­a­py Train­ing by the Alzheimer’s Research & Pre­ven­tion Foun­da­tion (“sharp­brains” = $75 off). Also avail­able as Livestream (“sharp­brainsLS” = $50 off)
  • Decem­ber 5–7th, online: Pre­lim­i­nary Agen­da announced @ 2017 Sharp­Brains Vir­tu­al Sum­mit: Brain Enhance­ment in the Dig­i­tal Age (“sharp2017” = 10% off)

 

Have a great September!

 

The Sharp­Brains Team

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Filed Under: Brain/ Mental Health, Technology & Innovation Tagged With: AARP, adhd, aging, brain, Brain-health, cognitive, cognitive-enhancement, disease, health, innovation, neuro, neurotech, Neurotechnology, technology

“We need people-centered wellness solutions that integrate brain health factors” — Charlie Hartwell, Operating Partner at the Bridge Builders Collaborative

August 21, 2017 by Alvaro Fernandez

Ques­tion: Char­lie, please share 1–2 major brain health needs you observe right now whose solu­tion demands a cre­ative and sig­nif­i­cant tech-enabled innovation.

Answer: I’d encour­age peo­ple to remem­ber that Brain Health is just part of over­all Whole Per­son Health.  Brain health solu­tions may reduce some dis­ease symp­toms but not help achieve actu­al well­ness.  We need peo­ple-cen­tered well­ness solu­tions that inte­grate brain health factors.

What advice would you give an entre­pre­neur launch­ing an inno­va­tion to address that?

Think hard about the way to grow and through what dis­tri­b­u­tion chan­nel you want to bring your solu­tion. No dis­tri­b­u­tion, no innovation.

– Char­lie Hartwell is the Oper­at­ing Part­ner at the Bridge Builders Col­lab­o­ra­tive, help­ing fund and sup­port the visions of social entre­pre­neurs build­ing bridges in the mind train­ing space. Char­lie is a Har­vard Busi­ness School grad­u­ate who has led, found­ed, run and worked in orga­ni­za­tions in 16 dif­fer­ent indus­tries. He will serve as a Judge in the first Brainnova­tions Pitch Con­test host­ed by the 2017 Sharp­Brains Vir­tu­al Sum­mit: Brain Enhance­ment in the Dig­i­tal Age (Decem­ber 5–7th, 2017).

– Brain­no­va­tions Judg­ing Panel

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Filed Under: Technology & Innovation Tagged With: Brain-health, disease, distribution channel, health, mind training, wellness

Executive Functions in Health and Disease: New book to help integrate Cognitive Neuroscience and Neuropsychology

August 8, 2017 by Dr. Elkhonon Goldberg

__________

Neu­ro­science used to be the monop­oly of a few elite uni­ver­si­ties locat­ed in a hand­ful of coun­tries. Neu­ropsy­chol­o­gy used to be a quaint niche dis­ci­pline rel­a­tive­ly uncon­nect­ed to the larg­er world of neu­ro­science and con­tent in its meth­ods with paper-and-pen­cil tests. [Read more…] about Exec­u­tive Func­tions in Health and Dis­ease: New book to help inte­grate Cog­ni­tive Neu­ro­science and Neuropsychology

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Filed Under: Brain/ Mental Health Tagged With: Alexander-Luria, clinical psychologists, cognition, cognitive-psychologists, disease, Executive-Functions, frontal-lobe, health, medical, neurologists, neuropsychologists, Neuropsychology, neuroscience, neuroscientist, prefrontal-cortex, psychiatric, Psychiatrists

7 ways in which the Human Connectome Project is moving the brain research needle

September 19, 2016 by SharpBrains

humanconnectome———-

The Human Con­nec­tome Project: Progress and Prospects (Cere­brum):

“Under­stand­ing the human brain in health and dis­ease rep­re­sents a grand sci­en­tif­ic chal­lenge for the 21st cen­tu­ry and beyond. How does a col­lec­tion of 90 bil­lion neu­rons inter­con­nect­ed by 150 tril­lion synaps­es give rise to the extra­or­di­nary capa­bil­i­ties of human behav­ior and the amaz­ing diver­si­ty of tal­ents among the bil­lions of peo­ple pop­u­lat­ing our earth?” Keep read­ing The Human Con­nec­tome Project: Progress and Prospects over at the Dana Foun­da­tion website.

To learn more:

  • To Be (Your Con­nec­tome), or Not to Be (Your Genome)

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Filed Under: Technology & Innovation Tagged With: behavior, brain, Connectome, disease, health, human-brain, Neurons

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