Alzheimer-disease

Study: High Cognitive Reserve (CR) seen to significantly lower dementia risk even in the presence of high Alzheimer’s Disease (AD) neuropathology

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Fig­ure 2. Inci­dence Rates of Demen­tia per 1000 Per­son-Years by Cog­ni­tive Reserve (CR) Ter­tile and Brain Pathol­o­gy; adjust­ed for age, sex, smok­ing, alco­hol con­sump­tion, phys­i­cal activ­i­ty, body mass index, heart dis­ease, hyper­ten­sion, cere­brovas­cu­lar dis­ease, dia­betes, and apolipopro­tein E e4. AD indi­cates Alzheimer dis­ease. Source: Xu H et al (2020)

Lifes­pan Cog­ni­tive Reserve—A Secret to Cop­ing With Neu­rode­gen­er­a­tive Pathol­o­gy (JAMA Neu­rol­o­gy editorial):

Giv­en the lim­it­ed suc­cess of ther­a­peu­tic inter­ven­tions for Alzheimer dis­ease, there is increased inter­est in under­stand­ing whether mod­i­fi­able fac­tors can help cope with or post­pone the appear­ance of brain pathol­o­gy. It is esti­mat­ed that about 35% of Alzheimer risk is mod­i­fi­able. Epi­demi­o­log­ic stud­ies have shown that life­time expo­sures to high­er edu­ca­tion, high­er occu­pa­tion­al attain­ment, and cog­ni­tive­ly stim­u­lat­ing activ­i­ties are asso­ci­at­ed with reduced risk of Alzheimer demen­tia. Autop­sy stud­ies have shown interindi­vid­ual dif­fer­ences in the amount of brain pathol­o­gy peo­ple can tol­er­ate before man­i­fest­ing cog­ni­tive impair­ments, and autop­sied brains of about one-third of indi­vid­u­als who are cog­ni­tive­ly nor­mal meet neu­ropatho­log­i­cal cri­te­ria for Alzheimer dis­ease. [Read more…] about Study: High Cog­ni­tive Reserve (CR) seen to sig­nif­i­cant­ly low­er demen­tia risk even in the pres­ence of high Alzheimer’s Dis­ease (AD) neuropathology

Update: Moderate lifetime drinking may lead to lower Alzheimer-related beta amyloid deposits in the brain

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Time for a new edi­tion of Sharp­Brains’ e‑newsletter.

#1. First of all, it’s not all bad news this month. Study finds that mod­er­ate life­time drink­ing may lead to low­er Alzheimer-relat­ed beta amy­loid deposits in the brain

#2. And, talk about per­son­al­ized med­i­cine! This fas­ci­nat­ing study show­ing how brain imag­ing (fMRI) + machine learn­ing + inten­sive, non-inva­sive neu­rostim­u­la­tion = tar­get­ed treat­ments that can max­i­mize effi­ca­cy and min­i­mize side effects: Rein­vent­ing depres­sion treat­ment via tran­scra­nial mag­net­ic brain stim­u­la­tion (TMS)

#3. Also, not a minute too soon … Med­i­ta­tion apps have gone main­stream in the covid-19 era and Dig­i­tal health start-ups raised a record $3.1 bil­lion in Q1; focus will like­ly evolve from providers to con­sumers and employers

#4. Fyi, a very time­ly vir­tu­al event com­ing Tues­day April 28th, online: Explore strate­gies and tools to boost men­tal well­be­ing dur­ing (and after) Covid-19

#5. Now, “While Pear has an advan­tage over the com­pe­ti­tion in that its prod­ucts are backed by ran­dom­ized clin­i­cal tri­als, physi­cians and health plans are still work­ing out how to pre­scribe and pay for dig­i­tal ther­a­peu­tics.” The FDA clears Som­ryst, Pear’s dig­i­tal ther­a­peu­tic to treat chron­ic insomnia

#6. Net net, now is the time for indi­vid­ual and col­lec­tive action to shift to a health­i­er “new nor­mal” for all: 3 ways to pro­tect your men­tal health dur­ing –and after– COVID-19 (in Span­ish: Tres hábitos de higiene men­tal para vencer al COVID-19 y crear un futuro más salud­able). Want more? Enjoy these Three tips for wise minds to calm coro­n­avirus anxiety

#7. A small but impor­tant study for that hope­ful near future when uni­ver­si­ties and col­leges reopen their doors: Study finds mixed results of Adder­all as cog­ni­tive enhancer (seems to boost emo­tion more than cognition)

#8. But, first things first. “The Bee Gees song “Stayin’ Alive” reached #1 on the pop charts in 1977. Maybe it was the beat, maybe it was John Travolta’s danc­ing. Or maybe it’s that the Gibb broth­ers’ cen­tral lyric is quite lit­er­al­ly always play­ing in our head. Keep­ing us safe —that is, “stayin’ alive ”— is the pri­ma­ry mis­sion of the brain”

Enough with coro­n­avirus out­break. Any­thing else going on? Yes!

#9. The Right to Per­son­al Iden­ti­ty. The Right to Free Will. The Right to Men­tal Pri­va­cy. The Right to Equal Access to Men­tal Aug­men­ta­tion. The Right to Pro­tec­tion from Algo­rith­mic Bias. Will these five Neu­roR­ights help har­ness emerg­ing neu­rotech­nolo­gies for the com­mon good?

#10. “Today, the sci­en­tif­ic inves­ti­ga­tion of tran­scen­dent expe­ri­ences is, in my view, one of the most excit­ing fron­tiers in the sci­ence of well-being.” Tran­scend­ing Maslow’s famous “hier­ar­chy of needs” through Maslow’s own research on Peak Experiences

#11. You CAN have your cake and eat it too: Here’s a brain teas­er to stim­u­late your men­tal imagery, spa­tial rota­tion … and appetite

#12. Ques­tion: My first thought after con­grat­u­lat­ing myself on being so clever about some­thing? Tease your brain with these eight fun rid­dles…

 

Wish­ing you and yours a great month of May,

 

The Sharp­Brains Team

Study: Moderate lifetime drinking may lead to lower Alzheimer-related beta amyloid deposits in the brain

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Mod­er­ate drink­ing tied to low­er lev­els of Alzheimer’s brain pro­tein (Busi­ness Standard):

“Kore­an researchers stud­ied 414 men and women, aver­age age 71, who were free of demen­tia or alco­hol-relat­ed dis­or­ders. All under­went phys­i­cal exams, tests of men­tal acu­ity, and positron emis­sion tomog­ra­phy (PET) and mag­net­ic res­o­nance imag­ing (MRI) scans. They were care­ful­ly inter­viewed about their drink­ing habits.

The study, in PLOS Med­i­cine, mea­sured drink­ing in “stan­dard drinks” — 12 ounces of beer, five ounces of wine, or one-and-a-half ounces of hard liquor. Com­pared with abstain­ers, those who drank one to 13 stan­dard drinks a week had a 66 per cent low­er rate of beta amy­loid deposits in their brains. [Read more…] about Study: Mod­er­ate life­time drink­ing may lead to low­er Alzheimer-relat­ed beta amy­loid deposits in the brain

Next: Measuring the impact of space flight on cognitive performance and brain fitness

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The flight that brings space weight­less­ness to Earth (BBC Future):

“Five, four, three, two, one…”

Not many air­craft cap­tains give their pas­sen­gers a rock­et launch-style count­down before take-off, but this is no ordi­nary plane. For starters, every­one on board, apart from the crew, is a sci­en­tist and has passed a full med­ical check – includ­ing a heart assess­ment. This is not a trip for ner­vous fliers [Read more…] about Next: Mea­sur­ing the impact of space flight on cog­ni­tive per­for­mance and brain fitness

Review finds mixed results on the effectiveness and safety of brain and memory supplements

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Omega 3 supplementsNat­ur­al Sup­ple­ments and Vit­a­mins for Treat­ment and Pre­ven­tion of Demen­tia and Cog­ni­tive Decline (Psy­chi­atric Times):

“Demen­tia, also referred to as major neu­rocog­ni­tive dis­or­der (includ­ing Alzheimer dis­ease [AD]), is a grow­ing prob­lem because of increased lifes­pan. There is no known cure. Sev­er­al drugs are [Read more…] about Review finds mixed results on the effec­tive­ness and safe­ty of brain and mem­o­ry supplements

Brain training franchisor LearningRx settles FTC complaint about its marketing claims

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BrainTraining_learningRxLearn­ingRx To Pay $200K For Alleged­ly Unproven Claims That Brain Train­ing Can Improve Income, Treat Autism & ADHD (Con­sumerist):

“The com­pa­ny behind the Learn­ingRX “brain train­ing” pro­gram has agreed to pay a $200,000 set­tle­ment and to stop mak­ing claims that its sys­tem is clin­i­cal­ly proven to treat seri­ous health con­di­tions, or that it can [Read more…] about Brain train­ing fran­chisor Learn­ingRx set­tles FTC com­plaint about its mar­ket­ing claims