SharpBrains

On cognitive-physical training, brain biomarkers, dementia, ketamine, brain teasers, riddles and more

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Wel­come to the last 2022 edi­tion of Sharp­Brains e‑newsletter, fea­tur­ing a few select­ed brain health news and fun teasers to chal­lenge your brain and help us all think out­side the box.

#1. “Every­one agrees that Google Glass failed when it came to mar­ket, but to me, it’s a sym­bol of hope … It inspired peo­ple to think beyond tra­di­tion­al ways of mov­ing about our envi­ron­ment. Instead of look­ing down at a device, we could look out at the world and have an over­lay of dig­i­tal infor­ma­tion. It was one of the first steps in physical–digital con­ver­gence that we are see­ing today through­out many indus­tries. And as some­one who has cre­at­ed many inven­tions that nev­er left the lab or were too ear­ly for the mar­ket, I love the fact that Glass came out at all!” — wise words by neu­rotech entre­pre­neur Dr. Cori Lath­an in her new (and excel­lent) book. See Tech­nol­o­gy as a bridge in time: Shap­ing the future of brain health via today’s innovations–including those that “fail”

#2. “Some peo­ple want to do cog­ni­tive train­ing while mov­ing rather than sit­ting down, and that real­ly spoke to me as a pos­si­bil­i­ty for real ben­e­fits giv­en anec­do­tal sto­ries about games like ‘Dance Dance Rev­o­lu­tion.’” — Joaquin A. Anguera, asso­ciate pro­fes­sor at UCSF and direc­tor of Neuroscape‘s Clin­i­cal Divi­sion. See Study: A com­bined cog­ni­tive-phys­i­cal train­ing approach may enhance both mind and body as we age

#3. “Giv­en that ketamine’s rapid action and unex­pect­ed dis­so­cia­tive effects make it a poten­tial­ly worth­while option for treat­ing men­tal health prob­lems, we are on a mis­sion to unpack this mys­tery, at the cross­roads between phar­ma­col­o­gy and neu­ro­science.” See Study iden­ti­fies cog­ni­tive ben­e­fits of ket­a­mine in patients with treat­ment-resis­tant depression

#4. “The grat­i­tude writ­ing group main­tained grat­i­tude lev­els and decreased stress and neg­a­tive affect at one-month post-inter­ven­tion” — that main­te­nance aspect is espe­cial­ly inter­est­ing. See Thanks­giv­ing works: Grat­i­tude jour­nal­ing seen to low­er stress and neg­a­tive cog­ni­tive processes

#5. Impres­sive new funding–especially giv­en mar­ket conditions–with a goal to iden­ti­fy “brain bio­mark­ers by ana­lyz­ing EEG activ­i­ty, behav­ioral task per­for­mance, wear­able data, genet­ics, and oth­er fac­tors to match each patient with the right Alto drug.” See Pre­ci­sion psy­chi­a­try pio­neer Alto Neu­ro­science rais­es $35M to advance dig­i­tal bio­mark­er-to-treat­ment platform

#6. Some bad news. See The FDA ends pre­cer­ti­fi­ca­tion (Pre-Cert) pilot pro­gram, say­ing new author­i­ty required to reg­u­late soft­ware as a med­ical device (SaMD)

#7. And some great news: “(Péter Hudomi­et, study’s lead author) said it’s also pos­si­ble that, giv­en numer­ous stud­ies being released on steps to take to avoid demen­tia, some of the decline may be attrib­uted to peo­ple heed­ing such advice.” See Study finds sharp decrease (near­ly one-third) in the preva­lence of demen­tia among those 65+ in the Unit­ed States

#8. Final­ly, here are a few brain teasers to stim­u­late those neu­rons in your tem­po­ral lobes and to help us all think out­side the box.

 

Have a healthy and won­der­ful 2023!

 

The FDA ends precertification (Pre-Cert) pilot program, saying new authority required to regulate software as a medical device (SaMD)

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FDA acknowl­edges short­com­ings of Pre-Cert pilot in report (Reg­u­la­to­ry Focus):

The US Food and Drug Admin­is­tra­tion (FDA) said it needs addi­tion­al Con­gres­sion­al author­i­ty to move for­ward with its dig­i­tal health pre­cer­ti­fi­ca­tion (Pre-Cert) pro­gram. While the idea has been wide­ly laud­ed by var­i­ous stake­hold­ers, at least one expert said he feels vin­di­cat­ed for warn­ing the agency ear­ly on that it lacked the legal author­i­ty to ful­ly imple­ment pathway.

In 2017, the FDA pro­posed the idea of a Pre-Cert pro­gram that would act as a new path­way for soft­ware as a med­ical device (SaMD) prod­ucts, through which the agency could green-light such prod­ucts based on how much reg­u­la­tors trust the man­u­fac­tur­er. The agency has been run­ning a pilot pro­gram to test the fea­si­bil­i­ty of the pro­gram, but in a new report, FDA con­cedes it does not have the legal author­i­ty need­ed to cre­ate the pro­gram as orig­i­nal­ly envi­sioned. [Read more…] about The FDA ends pre­cer­ti­fi­ca­tion (Pre-Cert) pilot pro­gram, say­ing new author­i­ty required to reg­u­late soft­ware as a med­ical device (SaMD)

Study: A combined cognitive-physical training approach may enhance both mind and body as we age

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A com­bined cog­ni­tive and fit­ness train­ing helps restore old­er adults’ atten­tion abil­i­ties to young adult lev­els (Psy­Post):

A new study found promis­ing results for a com­bined phys­i­cal fit­ness and cog­ni­tive inter­ven­tion designed to enhance neu­ro­plas­tic­i­ty in old­er adults. Using a motion-cap­ture video game, the inter­ven­tion appeared to reme­di­ate age-relat­ed declines in atten­tion. The find­ings were pub­lished in the jour­nal npj Aging. [Read more…] about Study: A com­bined cog­ni­tive-phys­i­cal train­ing approach may enhance both mind and body as we age

Study finds sharp decrease (nearly one-third) in the prevalence of dementia among those 65+ in the United States

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Demen­tia plum­mets by near­ly one-third among U.S. seniors, RAND says (UPI):

The preva­lence of demen­tia in the Unit­ed States is declin­ing among peo­ple over age 65, falling dra­mat­i­cal­ly from 2000 to 2016, a RAND Corp. study says.

Nation­wide, the age-adjust­ed preva­lence of demen­tia fell to 8.5% of peo­ple over age 65 in 2016, down by near­ly one-third from 12.2% of peo­ple over age 65 in 2000, accord­ing to the researchers. [Read more…] about Study finds sharp decrease (near­ly one-third) in the preva­lence of demen­tia among those 65+ in the Unit­ed States

Precision psychiatry pioneer Alto Neuroscience raises $35M to advance digital biomarker-to-treatment platform

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Alto Neu­ro­science Rais­es $35M Series B Financ­ing (Fins­Mes):

Alto Neu­ro­science, a Los Altos, CA-based neu­ro-tech com­pa­ny which spe­cial­izes in pre­ci­sion psy­chi­a­try, rais­es $35M Series B Financ­ing … The com­pa­ny intends to use the funds to advance lead can­di­dates into Phase 2b stud­ies in major depres­sive dis­or­der … Pro­ceeds from the financ­ing will also be used to progress the company’s arti­fi­cial intel­li­gence-enabled brain bio­mark­er plat­form and launch new clin­i­cal tri­als in areas of high unmet med­ical need. Alto will report Phase 2a data in ear­ly 2023 and fur­ther antic­i­pates Phase 2b data read­outs by ear­ly 2024. [Read more…] about Pre­ci­sion psy­chi­a­try pio­neer Alto Neu­ro­science rais­es $35M to advance dig­i­tal bio­mark­er-to-treat­ment platform

On cognitive training, muscle mass, neurostimulation, brain teasers, apps, and more

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Wel­come to a new edi­tion of Sharp­Brains’ e‑newsletter, fea­tur­ing time­ly brain & inno­va­tion news and a few fun teasers to test your work­ing memory.

#1. Study: Build­ing mus­cle mass helps delay cog­ni­tive decline beyond the val­ue of exer­cise itself

“Teas­ing out exact­ly how mus­cle helps the brain remains a chal­lenge. There are plen­ty of indi­rect links … But Dr. Chevalier’s results sug­gest there may be more direct mech­a­nisms too. One pos­si­bil­i­ty is the role of myokines, a set of hor­mone-like mol­e­cules pro­duced by mus­cle cells that can trav­el to the brain and influ­ence mood, learn­ing and oth­er cog­ni­tive func­tions. Greater mus­cle mass may also help keep blood glu­cose lev­els in check, pro­tect­ing the brain from damage.”

#2. Clin­i­cians and aca­d­e­mics should engage users when review­ing apps, study finds

“More than half of the app rat­ings showed dis­agree­ment between par­tic­i­pants and pro­fes­sion­als … Par­tic­i­pants par­tic­u­lar­ly val­ued cer­tain aspects of men­tal health apps, which appear to be over­looked by pro­fes­sion­al review­ers. These includ­ed func­tions such as the abil­i­ty to track and mea­sure men­tal health and pro­vid­ing gen­er­al men­tal health edu­ca­tion. The cost of apps was among the most impor­tant fac­tors for participants.”

#3. Com­bined tDCS neu­rostim­u­la­tion and cog­ni­tive train­ing found to improve work­ing mem­o­ry among old­er adults–especially those with low­er start­ing capacity

“… indi­vid­ual char­ac­ter­is­tics influ­enced the out­come of com­bined cog­ni­tive train­ing and tDCS reg­i­mens, with the inter­ven­tion selec­tive­ly ben­e­fit­ing old-old adults with low­er work­ing mem­o­ry capac­i­ty. Future work should con­sid­er devel­op­ing indi­vid­u­al­ized treat­ments by con­sid­er­ing indi­vid­ual dif­fer­ences in cog­ni­tive profiles.”

#4. Head­space Health’s Leslie Witt on the future of men­tal health

“I fun­da­men­tal­ly believe in the pow­er of mind­ful­ness and med­i­ta­tion tools, but they can’t serve all men­tal health needs. And par­tic­u­lar­ly when someone’s in a state of acute anx­i­ety, acute depres­sion, they need access to pro­fes­sion­al, human services…We are build­ing out what I often call the mid­dle piece, the bridge that exists between the self-serve con­tent in the Head­space app and the text-based coach­ing, telether­a­py and telepsy­chi­a­try of the Gin­ger service.”

#5. Study: Prac­tic­ing grat­i­tude helps low­er phys­i­o­log­i­cal stress lev­els of the “express­er” AND the “receiv­er”

“The impli­ca­tion here is that you should let your grat­i­tude out when you feel it … That’s not to say that you should go around and make up grat­i­tude expres­sions for no rea­son. But, when you gen­uine­ly feel grat­i­tude, you should express it.” — Christo­pher Oveis, Direc­tor of the Empa­thy & Emo­tion Lab at UCSD

#6. Tak­ing your brain vitals: Sto­ries from a tech­no-opti­mist invent­ing the future of human performance

“My vision for DANA has always been that every time you go to the doc­tor, in addi­tion to tak­ing your height, weight, blood pres­sure, and tem­per­a­ture, they will take your DANA brain vital. When mea­sur­ing your brain health becomes sec­ond nature—as com­mon as check­ing your blood pressure—it will empow­er every­one, no mat­ter their age, to spot changes soon­er and take action.” — Cori Lath­an, CEO of Anthro­Tron­ix, in her great new book.

#7. UK agen­cies to review and update reg­u­la­tion of dig­i­tal men­tal health tools

Time­ly and impor­tant work to be done by the Med­i­cines and Health­care prod­ucts Reg­u­la­to­ry Agency (MHRA) and the Nation­al Insti­tute for Health and Care Excel­lence (NICE).

#8. Last but not least, let us share a few quick brain teasers to exer­cise your work­ing mem­o­ry … enjoy!

 

Wish­ing you and yours a healthy and warm month of November