More Evidence That Omega‑3 Supplements Don’t Work (Forbes):
“Once again researchers have failed to find any clinical benefit for omega‑3 supplements. In a new meta-analysis and systematic review published in JAMA, Evangelos Rizos and colleagues analyzed 20 randomized controlled trials including 68,680 patients and found no significant effect on any of the endpoints…Although early studies suggested a benefit for omega‑3 supplements, the accumulation of evidence has resulted in a consistent failure to confirm this benefit, according to the authors. Current evidence, they concluded, does “not justify the use of omega‑3 as a structured intervention in everyday clinical practice or guidelines supporting dietary omega‑3 PUFA administration.”
Study: Association Between Omega‑3 Fatty Acid Supplementation and Risk of Major Cardiovascular Disease Events (JAMA):
- Study Selection: Randomized clinical trials evaluating the effect of omega‑3 on all-cause mortality, cardiac death, sudden death, myocardial infarction, and stroke.
- Conclusion: Overall, omega‑3 PUFA supplementation was not associated with a lower risk of all-cause mortality, cardiac death, sudden death, myocardial infarction, or stroke based on relative and absolute measures of association.
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