Psychotherapy

Study finds MDMA-assisted therapy to be safe and highly effective to treat severe PTSD

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The First Phase 3 Suc­cess for Psy­che­delics Will Pave the Way for an Indus­try (Bar­ron’s):

Post-trau­mat­ic stress dis­or­der is a crip­pling, hard-to-treat psy­chi­atric afflic­tion. Amer­i­ca spends bil­lions of dol­lars year­ly just on the vet­er­ans who suf­fer from PTSD. So it’s heart­en­ing to see the report of a promis­ing new treat­ment, pub­lished Mon­day in Nature Med­i­cine. [Read more…] about Study finds MDMA-assist­ed ther­a­py to be safe and high­ly effec­tive to treat severe PTSD

On Brain Awareness Week, mental health innovation, tDCS, biofeedback, psychedelics, and more

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Wel­come to a new edi­tion of Sharp­Brains’ e‑newsletter, start­ing with some ideas to get in the mood for Brain Aware­ness Week next month (March 15–21st). May BAW 2021 be a hun­dred times more upbeat than last year’s…

#1. Sev­en brain teasers and a neu­ro­plas­tic­i­ty pod­cast to cel­e­brate Brain Aware­ness Week 2021

#2. Imag­ine what this capa­bil­i­ty may mean just a few years from now. Should/ will Google alert Gmail users about their (future) cog­ni­tive sta­tus? Study: Arti­fi­cial intel­li­gence pro­gram iden­ti­fies lin­guis­tic mark­ers that pre­dict, with 70% accu­ra­cy, who gets Alzheimer’s Dis­ease years later

#3. Sim­i­lar to what hap­pened to Thync back in 2016, Halo Neu­ro­science strug­gled to com­mer­cial­ize tDCS as a non-med­ical device and the tech­nol­o­gy is being repur­posed for clin­i­cal use. Neu­ro­mod­u­la­tion devel­op­er Halo Neu­ro­science clos­es its doors; Flow Neu­ro­science acquires assets

#4. Here you have a cou­ple recent meta-analy­ses sug­gest­ing a grow­ing adop­tion in the near future of web-based, and increas­ing­ly per­son­al­ized, inter­ven­tions. Grow­ing research points to expand­ing adop­tion of online cog­ni­tive behav­ioral ther­a­pies, both guid­ed and unguided

#5. “If there is any­thing we’ve seen out of this year, it’s real­ly become that fourth pil­lar of ben­e­fits for every employ­er out there. Every­one has med­ical, den­tal and vision. Men­tal health has now real­ly become that fourth pil­lar of ben­e­fits for all employ­ers.” — Alyson Wat­son, CEO and founder of Mod­ern Health. Four trends accel­er­at­ing men­tal health inno­va­tion in the COVID/ post-COVID era

#6. “Access to men­tal health­care is a human right that shouldn’t be buried by stig­ma, lack of access, or afford­abil­i­ty.” — Oliv­er Har­ri­son, CEO of Koa Health. Dig­i­tal men­tal health start-up Koa Health rais­es €30M to accel­er­ate growth in Europe and the US

#7. “Just as the viral pan­dem­ic has accel­er­at­ed vac­cine devel­op­ment, this glob­al cri­sis has brought togeth­er men­tal health experts from the pub­lic and pri­vate sec­tor around the world to address what is sure­ly a sec­ond pan­dem­ic trig­gered by loss, anx­i­ety, and social iso­la­tion” — Thomas Insel, MD, co-founder of Human­est Care. Sur­vey finds con­cerns AND hope to address grow­ing men­tal health needs due to the covid pandemic

#8. Can biofeed­back-based videogames help chil­dren bet­ter man­age stress? Mag­el­lan Health and Might­i­er secure $2 mil­lion NIMH grant to investigate

#9. “The Organ­i­sa­tion for the Review of Care and Health Apps (ORCHA) has reviewed almost 600 men­tal health apps … only 29.6% meet qual­i­ty thresh­olds” The land­scape of dig­i­tal men­tal health apps: huge unmet needs, qual­i­ty con­cerns, app stores asked to ensure transparency

#10. Final­ly, an idea out there worth explor­ing … Next: Psy­che­del­ic-assist­ed psychotherapy?

Have a healthy and stim­u­lat­ing month of March,

The Sharp­Brains Team

Next: Psychedelic-assisted psychotherapy?

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How ecsta­sy and psilo­cy­bin are shak­ing up psy­chi­a­try (Nature):

… The Impe­r­i­al study was one of a spate of clin­i­cal tri­als launched over the past few years using illic­it psy­che­del­ic drugs such as psilo­cy­bin, lyser­gic acid diethy­lamide (LSD) and MDMA (3,4‑methylenedioxymethamphetamine, also known as mol­ly or ecsta­sy) to treat men­tal-health dis­or­ders, gen­er­al­ly with the close guid­ance of a psy­chi­a­trist or psy­chother­a­pist. The idea has been around for decades — or cen­turies in some cul­tures — but the momen­tum has picked up dras­ti­cal­ly over the past few years as investors and sci­en­tists have begun to cham­pi­on the approach again. [Read more…] about Next: Psy­che­del­ic-assist­ed psychotherapy?

Update: Understanding Brain Health via Cosmological Health, and vice versa

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LEFT: SECTION OF CEREBELLUM, WITH MAGNIFICATION FACTOR 40X, OBTAINED WITH ELECTRON MICROSCOPY (DR. E. ZUNARELLI, UNIVERSITY HOSPITAL OF MODENA); RIGHT: SECTION OF A COSMOLOGICAL SIMULATION, WITH AN EXTENSION OF 300 MILLION LIGHT-YEARS ON EACH SIDE (VAZZA ET AL. 2019 A&A). CREDIT: UNIVERSITY OF BOLOGNA

Wel­come to a new edi­tion of Sharp­Brains’ e‑newsletter, fea­tur­ing fas­ci­nat­ing find­ings, books and resources for life­long brain health.

#1. “The human brain (sec­tion; left image above) func­tions thanks to its wide neu­ronal net­work that is deemed to con­tain approx­i­mate­ly 69 bil­lion neu­rons. On the oth­er hand, the observ­able uni­verse (sec­tion sim­u­la­tion; right image) can count upon a cos­mic web of at least 100 bil­lion galax­ies. With­in both sys­tems, only 30% of their mass­es are com­posed of galax­ies and neu­rons. With­in both sys­tems, galax­ies and neu­rons arrange them­selves in long fil­a­ments or nodes between the fil­a­ments. Final­ly, with­in both sys­tems, 70% of the dis­tri­b­u­tion of mass or ener­gy is com­posed of com­po­nents play­ing an appar­ent­ly pas­sive role: water in the brain and dark ener­gy in the observ­able Uni­verse.” Under­stand­ing Brain Health via Cos­mo­log­i­cal Health, and vice versa

#2. One very smart and gen­er­ous brain to bright­en your day: Indi­an teacher Ran­jitsinh Disale wins annu­al $1M Glob­al Teacher Prize; shares half with 9 finalists

#3. “Of all the qual­i­ties par­ents can cul­ti­vate in their chil­dren, hope and opti­mism are the most pre­cious. We can nur­ture hope and opti­mism in our kids by demon­strat­ing that we always have some con­trol over our envi­ron­ment and our­selves. The future isn’t a tide that’s going to crush us, it’s a wave we’re a part of.” — Made­line Levine, author of Ready or Not. Three favorite 2020 books on par­ent­ing and men­tal health

#4. A superb mem­oir on becom­ing a psy­chother­a­py pio­neer and best­selling writer: Becom­ing Myself, by Irvin D. Yalom

#5. This sur­vey of 2500 fam­i­lies about what ADHD treat­ments seem to work/ not work finds that 49% of par­ents report Exer­cise to be ‘Extreme­ly or Very Effec­tive;’ above any oth­er treatment.

#6. On the dan­gers of “pro­duc­tiz­ing” lifestyle guide­lines that help build brain reserve and delay cog­ni­tive prob­lems; Buy­er beware: The sto­ry of a pricey and “cre­den­tialled” pro­gram to end Alzheimer’s Disease

#7. Now, giv­en that “In a new McK­in­sey report, 62% of employ­ees con­sid­er men­tal health issues a top chal­lenge,” it is good to see grow­ing resources and approach­es aimed at address­ing the chal­lenge: Calm rais­es $75 mil­lion, expands into cor­po­rate men­tal health and wellness

#8. And, step by step, dig­i­tal ther­a­peu­tics are going main­stream: Click Ther­a­peu­tics rais­es $30 mil­lion in debt to advance com­mer­cial­iza­tion of smok­ing ces­sa­tion app Clickotine

#9. Nev­er two with­out three: Pear Ther­a­peu­tics rais­es $80M; finds cost sav­ings of $2,150 per patient with opi­oid use disorder

#10. Final­ly, we asked our team and trust­ed advi­sors to com­pile a list of ideas to stay sane and healthy in the months ahead, pri­or­i­tiz­ing habits shown to pro­mote brain health, resilience and pos­i­tive neu­ro­plas­tic­i­ty: Enjoy these 3 New Year Res­o­lu­tions and 36 Ideas for a Hap­pi­er & Health­i­er 2021

Wish­ing you a safe, healthy and hap­py New Year

On becoming a psychotherapy pioneer and bestselling writer: A fantastic memoir by, and window into, the unique mind of Irvin D. Yalom

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If you’re inter­est­ed in the life of the mind, here you have an awe­some win­dow into a unique mind — a pro­found mem­oir by best­selling writer and psy­chother­a­py pio­neer Irvin D. Yalom. It was pub­lished back in 2017 but, like good wine, it has aged well and is more rel­e­vant today than ever.

Irvin D. Yalom, MD, is an emer­i­tus pro­fes­sor of psy­chi­a­try at Stan­ford Uni­ver­si­ty and a psy­chi­a­trist in pri­vate prac­tice in San Fran­cis­co. He is the author of many books, includ­ing Love’s Exe­cu­tion­er, The The­o­ry and Prac­tice in Group Psy­chother­a­py, and When Niet­zsche Wept. He lives with his wife in Palo Alto, California.

Descrip­tion: Irvin D. Yalom has made a career of inves­ti­gat­ing the lives of oth­ers. In this pro­found mem­oir, he turns his writ­ing and his ther­a­peu­tic eye on him­self. He opens his sto­ry with a night­mare: He is twelve, and is rid­ing his bike past the home of an acne-scarred girl. Like every morn­ing, he calls out, hop­ing to befriend her, “Hel­lo Measles!” But in his dream, the girl’s father makes Yalom under­stand that his dai­ly greet­ing had hurt her. For Yalom, this was the birth of empa­thy; he would not for­get the les­son. [Read more…] about On becom­ing a psy­chother­a­py pio­neer and best­selling writer: A fan­tas­tic mem­oir by, and win­dow into, the unique mind of Irvin D. Yalom

Neuromodulation device Relivion gets FDA clearance to help patients with major depression who don’t benefit from antidepressant medications

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Neu­rolief wins FDA break­through nod for wear­able neu­ro­mod for depres­sion (Mass Device):

Neu­rolief announced today that it received FDA break­through device des­ig­na­tion for its Reliv­ion DP sys­tem for treat­ing major depression.

Reliv­ion is a wear­able, non-inva­sive, mul­ti-chan­nel brain neu­ro­mod­u­la­tion device designed as an adjunc­tive treat­ment to phar­ma­ceu­ti­cal man­age­ment of major depres­sive dis­or­der (MDD) in adults who haven’t expe­ri­enced sat­is­fac­to­ry improve­ment from anti­de­pres­sant med­ica­tions, accord­ing to a news release. [Read more…] about Neu­ro­mod­u­la­tion device Reliv­ion gets FDA clear­ance to help patients with major depres­sion who don’t ben­e­fit from anti­de­pres­sant medications