cognitive decline

Study: Playing board games like Chess, Mahjong, Go, helps slow cognitive decline as we age (but with clear differences in neurobiology and improved function)

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Play­ing Board Games May Slow Cog­ni­tive Decline, Improve QoL (Med­scape):

Play­ing chess or oth­er board games slows cog­ni­tive decline and improves qual­i­ty of life in old­er patients, results of a new sys­tem­at­ic review suggest.

… After search­ing the pub­lished lit­er­a­ture, Pozzi and his col­leagues select­ed 15 stud­ies for the review. The stud­ies assessed the impact of board games on old­er indi­vid­u­als at risk of, or with cog­ni­tive impair­ment, or those with mild cog­ni­tive impair­ment (MCI) at any age. [Read more…] about Study: Play­ing board games like Chess, Mahjong, Go, helps slow cog­ni­tive decline as we age (but with clear dif­fer­ences in neu­ro­bi­ol­o­gy and improved function)

Pilot program by IU and Davos Alzheimer’s Collaborative to test AI-powered cognitive screening at scale

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How AI, Dig­i­tal Screen­ing Tools Can Help Flag Ear­ly Cog­ni­tive Decline (Health IT Analytics):

Ear­ly diag­no­sis of Alzheimer’s and oth­er demen­tias remains at the fore­front of efforts to min­i­mize the impact of these neu­rode­gen­er­a­tive dis­eases. But chal­lenges such as increased life expectan­cy and the risks of aging, along with com­plex­i­ties in diag­no­sis and treat­ment result­ing from mixed brain patholo­gies, make ear­ly detec­tion dif­fi­cult … A new pilot pro­gram at Indi­ana Uni­ver­si­ty School of Med­i­cine and Indi­ana Uni­ver­si­ty Health, in col­lab­o­ra­tion with the Davos Alzheimer’s Col­lab­o­ra­tive (DAC), seeks to tack­le these issues using dig­i­tal screen­ing tools. [Read more…] about Pilot pro­gram by IU and Davos Alzheimer’s Col­lab­o­ra­tive to test AI-pow­ered cog­ni­tive screen­ing at scale

On cognitive training, muscle mass, neurostimulation, brain teasers, apps, and more

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Wel­come to a new edi­tion of Sharp­Brains’ e‑newsletter, fea­tur­ing time­ly brain & inno­va­tion news and a few fun teasers to test your work­ing memory.

#1. Study: Build­ing mus­cle mass helps delay cog­ni­tive decline beyond the val­ue of exer­cise itself

“Teas­ing out exact­ly how mus­cle helps the brain remains a chal­lenge. There are plen­ty of indi­rect links … But Dr. Chevalier’s results sug­gest there may be more direct mech­a­nisms too. One pos­si­bil­i­ty is the role of myokines, a set of hor­mone-like mol­e­cules pro­duced by mus­cle cells that can trav­el to the brain and influ­ence mood, learn­ing and oth­er cog­ni­tive func­tions. Greater mus­cle mass may also help keep blood glu­cose lev­els in check, pro­tect­ing the brain from damage.”

#2. Clin­i­cians and aca­d­e­mics should engage users when review­ing apps, study finds

“More than half of the app rat­ings showed dis­agree­ment between par­tic­i­pants and pro­fes­sion­als … Par­tic­i­pants par­tic­u­lar­ly val­ued cer­tain aspects of men­tal health apps, which appear to be over­looked by pro­fes­sion­al review­ers. These includ­ed func­tions such as the abil­i­ty to track and mea­sure men­tal health and pro­vid­ing gen­er­al men­tal health edu­ca­tion. The cost of apps was among the most impor­tant fac­tors for participants.”

#3. Com­bined tDCS neu­rostim­u­la­tion and cog­ni­tive train­ing found to improve work­ing mem­o­ry among old­er adults–especially those with low­er start­ing capacity

“… indi­vid­ual char­ac­ter­is­tics influ­enced the out­come of com­bined cog­ni­tive train­ing and tDCS reg­i­mens, with the inter­ven­tion selec­tive­ly ben­e­fit­ing old-old adults with low­er work­ing mem­o­ry capac­i­ty. Future work should con­sid­er devel­op­ing indi­vid­u­al­ized treat­ments by con­sid­er­ing indi­vid­ual dif­fer­ences in cog­ni­tive profiles.”

#4. Head­space Health’s Leslie Witt on the future of men­tal health

“I fun­da­men­tal­ly believe in the pow­er of mind­ful­ness and med­i­ta­tion tools, but they can’t serve all men­tal health needs. And par­tic­u­lar­ly when someone’s in a state of acute anx­i­ety, acute depres­sion, they need access to pro­fes­sion­al, human services…We are build­ing out what I often call the mid­dle piece, the bridge that exists between the self-serve con­tent in the Head­space app and the text-based coach­ing, telether­a­py and telepsy­chi­a­try of the Gin­ger service.”

#5. Study: Prac­tic­ing grat­i­tude helps low­er phys­i­o­log­i­cal stress lev­els of the “express­er” AND the “receiv­er”

“The impli­ca­tion here is that you should let your grat­i­tude out when you feel it … That’s not to say that you should go around and make up grat­i­tude expres­sions for no rea­son. But, when you gen­uine­ly feel grat­i­tude, you should express it.” — Christo­pher Oveis, Direc­tor of the Empa­thy & Emo­tion Lab at UCSD

#6. Tak­ing your brain vitals: Sto­ries from a tech­no-opti­mist invent­ing the future of human performance

“My vision for DANA has always been that every time you go to the doc­tor, in addi­tion to tak­ing your height, weight, blood pres­sure, and tem­per­a­ture, they will take your DANA brain vital. When mea­sur­ing your brain health becomes sec­ond nature—as com­mon as check­ing your blood pressure—it will empow­er every­one, no mat­ter their age, to spot changes soon­er and take action.” — Cori Lath­an, CEO of Anthro­Tron­ix, in her great new book.

#7. UK agen­cies to review and update reg­u­la­tion of dig­i­tal men­tal health tools

Time­ly and impor­tant work to be done by the Med­i­cines and Health­care prod­ucts Reg­u­la­to­ry Agency (MHRA) and the Nation­al Insti­tute for Health and Care Excel­lence (NICE).

#8. Last but not least, let us share a few quick brain teasers to exer­cise your work­ing mem­o­ry … enjoy!

 

Wish­ing you and yours a healthy and warm month of November

Study: Building muscle mass helps delay cognitive decline beyond the value of exercise itself

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A new rea­son to build mus­cle: brain health (The Globe and Mail):

… a recent study from researchers at McGill Uni­ver­si­ty, pub­lished in the jour­nal JAMA Net­work Open, offers a new rea­son for con­tin­u­ing to work on build­ing mus­cle: It’s good for your brain, not just your biceps. Greater mus­cle mass, the results sug­gest, helps ward off cog­ni­tive decline in old­er adults beyond what you’d expect based on their exer­cise lev­els alone. [Read more…] about Study: Build­ing mus­cle mass helps delay cog­ni­tive decline beyond the val­ue of exer­cise itself

Dual decline in gait speed and memory function seen as most predictive of future dementia

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Walk­ing Speed Helps Pre­dict Future Demen­tia (Med­Page Today):

Dual decline in gait speed and cog­ni­tion car­ried a high­er risk of demen­tia than either gait-only decline or cog­ni­tive-only decline, report­ed Taya Col­ly­er, PhD, of Monash Uni­ver­si­ty in Vic­to­ria, Aus­tralia, and co-authors, in JAMA Net­work Open…

[Read more…] about Dual decline in gait speed and mem­o­ry func­tion seen as most pre­dic­tive of future dementia

Altoida raises further $14 million to “democratize digital cognitive assessment at scale” via augmented reality (AR) and AI

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Altoi­da snags Mer­ck KGaA-led $14M fund­ing round for Alzheimer’s diag­nos­tic app (Fierce Biotech):

The $14 mil­lion top-up came from a mix of old and new investors, co-led by White­cap Ven­ture Part­ners and Mer­ck KGaA’s cor­po­rate VC arm, M Ven­tures, which also led the ini­tial tranche of series A financ­ing … The new­ly upsized fund­ing will help Altoi­da add to its work­force, pay for intel­lec­tu­al prop­er­ty and reg­u­la­to­ry fil­ings and con­tin­ue devel­op­ing its tech plat­form to assess neu­ro­log­i­cal func­tion. [Read more…] about Altoi­da rais­es fur­ther $14 mil­lion to “democ­ra­tize dig­i­tal cog­ni­tive assess­ment at scale” via aug­ment­ed real­i­ty (AR) and AI