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clinical-trials

Can the controversial FDA approval of Aduhelm backfire and delay the discovery of actual Alzheimer’s treatments? (Yes, it can)

June 21, 2021 by The Conversation

The U.S. Food and Drug Admin­is­tra­tion (FDA) recent­ly approved adu­canum­ab, the first treat­ment that aims to slow the pro­gres­sion of Alzheimer’s dis­ease. But approval of the drug has pro­voked mixed reac­tions from the sci­en­tif­ic community.

Alzheimer’s dis­ease is char­ac­ter­ized by pro­gres­sive mem­o­ry loss, spa­tial dis­ori­en­ta­tion and many oth­er cog­ni­tive and behav­iour­al dis­or­ders that ulti­mate­ly lead to a state of total depen­dence. [Read more…] about Can the con­tro­ver­sial FDA approval of Aduhelm back­fire and delay the dis­cov­ery of actu­al Alzheimer’s treat­ments? (Yes, it can)

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Filed Under: Brain/ Mental Health Tagged With: aducanumab, Aduhelm, Alzheimer's biomarkers, Alzheimer's drug, Alzheimers-disease, amyloid, Biogen, clinical-trials, FDA, FDA drug approval process, tau

Cumulus Neuroscience raises $8.3M to develop EEG-based wireless ‘Fitbit for the brain’

May 5, 2021 by SharpBrains

Belfast-based Cumu­lus rais­es €6.9m for its ‘Fit­bit for the brain’ (The Irish Times):

… For­mer­ly known as Brain­Wave­Bank, the com­pa­ny has devel­oped a wire­less elec­troen­cephalo­gram (EEG) head­set and pro­pri­etary soft­ware plat­form that use advanced ana­lyt­ics and machine learn­ing to mea­sure cog­ni­tive fitness.

“This fund­ing will allow us to build on the ground-break­ing advances we have made in remote, fre­quent mon­i­tor­ing of brain activ­i­ty and cog­ni­tive func­tion in the home, in part­ner­ship with lead­ing devel­op­ers of dig­i­tal bio­mark­ers,” said Mr Cun­ning­ham, the company’s chief exec­u­tive. [Read more…] about Cumu­lus Neu­ro­science rais­es $8.3M to devel­op EEG-based wire­less ‘Fit­bit for the brain’

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Filed Under: Brain/ Mental Health, Technology & Innovation Tagged With: Alzheimer’s Disease, BrainWaveBank, clinical-trials, CNS, CNS therapies, cognitive-fitness, Cumulus Neuroscience, dementia, Dementia Discovery Fund, digital biomarkers, EEG, electroencephalogram, FitBit, Fitbit for the brain, LifeArc, machine-learning, UK Future Fund

The NIH starts spending $1.5 billion in new Brain Research through Advancing Innovative Neuro-technologies (BRAIN) projects

March 7, 2018 by SharpBrains

___

NIH Starts to Spend $4.8 Bil­lion in “Extra” Cures Drug Research Mon­ey (P&T Community):

“The Nation­al Insti­tutes of Health (NIH) launched 110 new brain research projects in the fis­cal year end­ing last Sep­tem­ber (2017) with the first por­tion of the $1.5 bil­lion over 10 years it will hope­ful­ly receive from the 21st Cen­tu­ry Cures Act, which spread a total of $4.8 bil­lion over four NIH pro­grams. That is mon­ey over and above the NIH annu­al appro­pri­a­tion from Con­gress. The oth­er three “Inno­va­tion Funds” are: Pre­ci­sion Med­i­cine, Can­cer Moon­shot, and Regen­er­a­tive Medicine.

The $1.5 bil­lion in new Brain Research through Advanc­ing Inno­v­a­tive Neu­ro-tech­nolo­gies (BRAIN) research mon­ey seems par­tic­u­lar­ly impor­tant giv­en the announce­ment in Jan­u­ary that Pfiz­er was end­ing its Alzheimer’s research pro­gram [Read more…] about The NIH starts spend­ing $1.5 bil­lion in new Brain Research through Advanc­ing Inno­v­a­tive Neu­ro-tech­nolo­gies (BRAIN) projects

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Filed Under: Brain/ Mental Health, Technology & Innovation Tagged With: Alzheimers, brain, clinical-trials, Innovation Funds, Moonshot, National-Institutes-of-Health, Neuro-technologies, neurotechnologies, NIH, Pfizer

Survey: Parents view Exercise as more effective than Prescription Medications to treat children with ADHD

November 17, 2017 by Dr. David Rabiner

Con­sid­er how research sup­port for ADHD treat­ments are typ­i­cal­ly estab­lished. The ‘gold-stan­dard’ approach would be a ran­dom­ized-con­trolled tri­al in which chil­dren with ADHD are ran­dom­ly assigned to the treat­ment or con­trol group. The treat­ment, what­ev­er it hap­pens to be, would be care­ful­ly imple­ment­ed in a research-based pro­to­col. If pos­si­ble [Read more…] about Sur­vey: Par­ents view Exer­cise as more effec­tive than Pre­scrip­tion Med­ica­tions to treat chil­dren with ADHD

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Filed Under: Attention & ADD/ADHD, Education & Lifelong Learning Tagged With: AD/HD-treatments, ADDitude, ADDitude Magazine, adhd, behavioral-therapy, Brain-Training, clinical-trials, medication, mindfulness, Neurofeedback, randomized-controlled trial, treatments

Can better cognitive testing platforms accelerate pharma’s Alzheimer’s research and development efforts?

May 4, 2015 by SharpBrains

brain_AD.

Alzheimer’s cure behind the boom in brain sci­ence (Finan­cial Review):

“Bio­gen is one of many mem­bers of big phar­ma seek­ing the block­buster drug which will inevitably be worth mul­ti­ple bil­lions of dol­lars. Big phar­ma in the US spends about $US5 bil­lion a year on Alzheimer’s research and development.

Expo­nen­tial growth in the dis­ease over the past decade has not been accom­pa­nied by the devel­op­ment of approved drugs. In fact, [Read more…] about Can bet­ter cog­ni­tive test­ing plat­forms accel­er­ate pharma’s Alzheimer’s research and devel­op­ment efforts?

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Filed Under: Brain/ Mental Health, Technology & Innovation Tagged With: Alzheimers, Big-Pharma, Biogen, clinical-trials, cognitive test, Cognitive-impairment, CogState

Is the future of brain sensors and signals open-source or commercial? (Hint: Probably both)

June 12, 2014 by SharpBrains

OpenEphysNeu­ro­sci­en­tists Join the Open-Source Hard­ware Move­ment (IEEE Spectrum):

“Grad­u­ate stu­dents Josh Siegle and Jakob Voigts were plan­ning an ambi­tious series of exper­i­ments at their MIT neu­ro­science labs in 2011 when they ran into a prob­lem. [Read more…] about Is the future of brain sen­sors and sig­nals open-source or com­mer­cial? (Hint: Prob­a­bly both)

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Filed Under: Technology & Innovation Tagged With: brain sensors, brain signals, clinical-trials, FDA, MIT, neuroscience, neuroscience lab, Open Ephys, open-source

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