brain-aging

On mental fitness beliefs, lifestyles and new tools like apps, digital therapeutics, virtual reality, “brain age gaps” and more

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Wel­come to a new edi­tion of Sharp­Brains’ e‑newsletter, fea­tur­ing time­ly brain & men­tal health news and a fun cou­ple of math brain teasers.

#1. Study on the “ABCs of Men­tal Health” finds that sim­ply believ­ing you can improve men­tal well­be­ing helps actu­al­ly improve it

Beliefs mat­ter.

#2. “Dig­i­tal ther­a­peu­tics” vs. “Men­tal health apps”: A grow­ing debate on stan­dards, reg­u­la­tion and efficacy

Def­i­n­i­tions matter.

#3. How ’sleep­ing on it’ can help the pre­frontal cor­tex reg­u­late emo­tion­al respons­es, mak­ing us feel bet­ter in the morning

Sleep mat­ters.

#4. NICE in the UK issues rec­om­men­da­tion for Sleepio app, the dig­i­tal cog­ni­tive behav­iour­al ther­a­py for insom­nia by Big Health

Inno­va­tion mat­ters: “At a price of £45 per per­son, Sleepio is cost sav­ing com­pared with usu­al treat­ment in pri­ma­ry care. This is based on an analy­sis of pri­ma­ry care resource use data before and after Sleepio was intro­duced in 9 GP prac­tices. Health­care costs were low­er at 1 year, most­ly because of few­er GP appoint­ments and sleep­ing pills prescribed.”

#5. New book pro­vides prac­ti­cal guid­ance for women (and men) to rebal­ance our lifestyles and build Cog­ni­tive Reserve

Lifestyle mat­ters: “The more com­plex our lives are, the more we need sim­ple things that can ground us and help us to be more resilient – to rebal­ance and rebal­ance and rebal­ance again. Build­ing the men­tal mus­cles to find bal­ance when one gets off bal­ance is a crit­i­cal skill thrive and to build cog­ni­tive reserve in our fast-chang­ing times. As our month­ly gath­er­ings showed us over the years, prac­tic­ing rebal­ance in good com­pa­ny not only rein­forces neur­al path­ways and capa­bil­i­ties but also strength­ens the bonds of trust and con­fi­dence that are invalu­able to build a healthy envi­ron­ment to thrive in.”

#6. Study: Auto­mat­ed VR psy­chother­a­py can help reduce anx­i­ety and dis­tress, espe­cial­ly among those with psy­chosis and severe agoraphobia

One of the ben­e­fits of VR is that patients know they are in a sim­u­la­tion, which enables “psy­cho­log­i­cal dis­tance from prob­lem­at­ic reac­tions,” the study authors wrote. “The process of find­ing the best uses and imple­men­ta­tion meth­ods of this immer­sive tech­nol­o­gy at scale in men­tal health is only beginning.”

#7. Fund­ing for dig­i­tal health start-ups, espe­cial­ly in men­tal health, fall sub­stan­tial­ly in Q1’22

“While all tech sec­tors received small­er fund­ing totals than the pre­vi­ous quar­ter, dig­i­tal health plunged much fur­ther than oth­ers did … investor inter­est in men­tal health tech wavered as the mar­ket and pub­lic com­pa­nies like Talk­space and Cere­bral come under scrutiny.”

#8. Deep learn­ing mod­el built on neu­roimag­ing data iden­ti­fies “Brain Age Gaps” as mark­ers of Alzheimer’s dis­ease (AD)

“The main find­ing of our study is that we could indeed find evi­dence that high brain age gap is behav­ing as an accel­er­at­ed brain aging bio­mark­er.” — Dr. David Jones, neu­rol­o­gist at Mayo Clinic

Final­ly, a cou­ple fun brain teasers to help you flex your math/ cog­ni­tive men­tal muscles:

#9. Will you fin­ish your the­sis on time?

#10. Math brain teas­er requir­ing no math — just per­cep­tion and cognition

 

Wish­ing you and yours a healthy and stim­u­lat­ing June!

Deep learning model built on neuroimaging data identifies “Brain Age Gaps” as markers of Alzheimer’s disease (AD)

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Brain Age Gap is a Com­pos­ite Bio­mark­er for Demen­tia Pathol­o­gy or Sever­i­ty (GEN):

Mayo Clin­ic sci­en­tists have devel­oped a com­pu­ta­tion­al mod­el that pre­dicts brain age using a large col­lec­tion of neu­roimag­ing data obtained using FDG-PET (flu­o­rodeoxyglu­cose positron emis­sion tomog­ra­phy) and struc­tur­al MRI (mag­net­ic res­o­nance imag­ing). The deep learn­ing-based mod­el tests the rela­tion­ship between brain age gaps in var­i­ous forms of demen­tia, includ­ing mild cog­ni­tive impair­ment (MCI), Alzheimer’s dis­ease (AD), fron­totem­po­ral demen­tia (FTD), and Lewy body demen­tia (LBD), as well as in nor­mal brains.

[Read more…] about Deep learn­ing mod­el built on neu­roimag­ing data iden­ti­fies “Brain Age Gaps” as mark­ers of Alzheimer’s dis­ease (AD)

Complex occupations help protect our brains from aging-related cognitive decline

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Cog­ni­tive aging: Work helps our brain (AAAS):

A recent study shows that work plays an active role in keep­ing our brains healthy. “We have demon­strat­ed the role of work­ing activ­i­ty on cog­ni­tive per­for­mance”. Pro­fes­sor Raf­fael­la Rumiati says … “Many stud­ies have been focused on the fac­tors influ­enc­ing our brain aging and dif­fer­ences in cog­ni­tive decline have been often observed in asso­ci­a­tion with edu­ca­tion or oth­er relat­ed to qual­i­ty of life. From our analy­sis it emerges that the type of work activ­i­ty also con­tributes to the dif­fer­ences in nor­mal and patho­log­i­cal cog­ni­tive aging”. [Read more…] about Com­plex occu­pa­tions help pro­tect our brains from aging-relat­ed cog­ni­tive decline

Don’t worry, be happy: How excessive worrying may influence the rate of neurodegeneration

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Wor­ry­ing and the Aging Brain (Dana Foundation):

Over the past decade, sci­en­tists and clin­i­cians have not­ed a sig­nif­i­cant asso­ci­a­tion between com­mon men­tal health con­di­tions and accel­er­at­ed brain aging—the changes to brain struc­ture, phys­i­ol­o­gy, and func­tion that are thought to lead to lat­er cog­ni­tive decline. Both depres­sion and anx­i­ety dis­or­ders, for exam­ple, are strong­ly cor­re­lat­ed with the devel­op­ment of demen­tias includ­ing Alzheimer’s dis­ease lat­er in life, yet it has been unclear why. Neu­ro­sci­en­tists and geron­tol­o­gists around the globe have dili­gent­ly worked to inves­ti­gate which par­tic­u­lar symp­toms might con­tribute to age-relat­ed cog­ni­tive decline. [Read more…] about Don’t wor­ry, be hap­py: How exces­sive wor­ry­ing may influ­ence the rate of neurodegeneration

Brain scans show lower accumulation of tau and amyloid pathology among cognitive “super-agers”

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– Tau (blue) and amy­loid (orange) dis­tri­b­u­tion pat­terns for super-agers, nor­mal-agers and MCI patients, when com­pared to a group of younger, healthy, cog­ni­tive­ly nor­mal, amy­loid-neg­a­tive indi­vid­u­als. Cred­it: Mer­le C. Hoenig.

Super-Agers Show Resis­tance to Tau and Amy­loid Accu­mu­la­tion, Main­tain High Cog­ni­tive Func­tion (Soci­ety of Nuclear Med­i­cine and Mol­e­c­u­lar Imag­ing press release):

Super-agers, or indi­vid­u­als whose cog­ni­tive skills are above the norm even at an advanced age, have been found to have increased resis­tance to tau and amy­loid pro­teins, accord­ing to research pre­sent­ed at the Soci­ety of Nuclear Med­i­cine and Mol­e­c­u­lar Imag­ing (SNMMI) 2020 Annu­al Meet­ing. An analy­sis of positron emis­sion tomog­ra­phy (PET) scans has shown that com­pared to nor­mal-agers and those with mild cog­ni­tive impair­ment, super-agers have a low­er bur­den of tau and amy­loid pathol­o­gy asso­ci­at­ed with neu­rode­gen­er­a­tion, which prob­a­bly allows them to main­tain their cog­ni­tive per­for­mance. An image show­ing the com­par­i­son of tau and amy­loid dis­tri­b­u­tion pat­terns in these dif­fer­ent cog­ni­tive aging tra­jec­to­ries has been select­ed as SNMMI’s 2020 Image of the Year. [Read more…] about Brain scans show low­er accu­mu­la­tion of tau and amy­loid pathol­o­gy among cog­ni­tive “super-agers”

The Future of Brain Health & Wellness as seen by Joy Ventures, Total Brain, Vielight, Arrowsmith, Peak, CABHI and NeurotechX

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Dur­ing Expo Day at the 2019 Sharp­Brains Vir­tu­al Sum­mit (May 7–9th), select­ed Sum­mit Spon­sors and Part­ners had the oppor­tu­ni­ty to show­case their most promis­ing brain health & well­ness ini­tia­tives and solu­tions. We hope you enjoy their slid­edecks below! (and please remem­ber that the full record­ings are avail­able for pur­chase here)

8.30am. Dr. Hag­it Alon, VP Sci­en­tif­ic Affairs of Joy Ven­tures,  pre­sent­ed their “Neu­ro-Well­ness” phi­los­o­phy and approach to invest in sci­en­tif­ic research and in entrepreneurs: 

 

9.15am. Mar­cel Legrand, Chief Rev­enue Offi­cer of Total Brain, pro­vid­ed an overview of their new plat­form to bet­ter assess, under­stand and improve brain capacities:

 

10am. Dr. Lew Lim, Founder & CEO of Vielight, explored the lat­est on pho­to­bio­mod­u­la­tion and brain stimulation: 

 

11am. Deb­bie Gilmore, Exec­u­tive Direc­tor of The Arrow­smith Pro­gram, dis­cussed plans to bet­ter equip 100+ schools help­ing stu­dents with spe­cial needs: 

 

11.45am. Xavier Louis, CEO of Peak, out­lined their plans to bring to mar­ket engag­ing, self-serve and evi­dence-based dig­i­tal therapeutics:

 

12.30pm. Mel Barsky, Direc­tor at Cen­tre for Aging + Brain Health Inno­va­tion (CABHI), announced a new call for inno­va­tion where CABHI will be fund­ing nov­el ideas from point-of-care work­ers that can help to improve brain health in old­er adults:

 

1.15pm. Syd­ney Swaine-Simon, Co-Founder of Neu­rotechX, intro­duced new learn­ing resources and their grow­ing com­mu­ni­ty of neu­rotech experts, entre­pre­neurs, and enthusiasts: 

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