Brain Age Gap is a Composite Biomarker for Dementia Pathology or Severity (GEN):
Mayo Clinic scientists have developed a computational model that predicts brain age using a large collection of neuroimaging data obtained using FDG-PET (fluorodeoxyglucose positron emission tomography) and structural MRI (magnetic resonance imaging). The deep learning-based model tests the relationship between brain age gaps in various forms of dementia, including mild cognitive impairment (MCI), Alzheimer’s disease (AD), frontotemporal dementia (FTD), and Lewy body dementia (LBD), as well as in normal brains.