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Alto Neuroscience raises $60M (equity + credit) to help fix the “trial and error” approach to psychiatric medication

January 31, 2023 by SharpBrains

Alto Neu­ro­science bags $25M for four Phase II drugs (End­points News):

Anoth­er $25 mil­lion is flow­ing the way of a Cal­i­for­nia biotech attempt­ing to fix the “tri­al and error” sys­tem in neu­ro­science drug R&D.

Alto Neu­ro­science picked up the cap­i­tal from Alpha Wave Ven­tures via an exten­sion to its Series B, bring­ing total equi­ty raised to $100 mil­lion since the startup’s 2019 found­ing. [Read more…] about Alto Neu­ro­science rais­es $60M (equi­ty + cred­it) to help fix the “tri­al and error” approach to psy­chi­atric medication

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Filed Under: Brain/ Mental Health Tagged With: Alpha Wave Ventures, Alto Neuroscience, behavioral task measurements, cognition, depression meds, EEG activity, emotion, Genetics, K2 HealthVentures, neuroscience, sleep

On mental fitness beliefs, lifestyles and new tools like apps, digital therapeutics, virtual reality, “brain age gaps” and more

May 31, 2022 by SharpBrains

Wel­come to a new edi­tion of Sharp­Brains’ e‑newsletter, fea­tur­ing time­ly brain & men­tal health news and a fun cou­ple of math brain teasers.

#1. Study on the “ABCs of Men­tal Health” finds that sim­ply believ­ing you can improve men­tal well­be­ing helps actu­al­ly improve it

Beliefs mat­ter.

#2. “Dig­i­tal ther­a­peu­tics” vs. “Men­tal health apps”: A grow­ing debate on stan­dards, reg­u­la­tion and efficacy

Def­i­n­i­tions matter.

#3. How ’sleep­ing on it’ can help the pre­frontal cor­tex reg­u­late emo­tion­al respons­es, mak­ing us feel bet­ter in the morning

Sleep mat­ters.

#4. NICE in the UK issues rec­om­men­da­tion for Sleepio app, the dig­i­tal cog­ni­tive behav­iour­al ther­a­py for insom­nia by Big Health

Inno­va­tion mat­ters: “At a price of £45 per per­son, Sleepio is cost sav­ing com­pared with usu­al treat­ment in pri­ma­ry care. This is based on an analy­sis of pri­ma­ry care resource use data before and after Sleepio was intro­duced in 9 GP prac­tices. Health­care costs were low­er at 1 year, most­ly because of few­er GP appoint­ments and sleep­ing pills prescribed.”

#5. New book pro­vides prac­ti­cal guid­ance for women (and men) to rebal­ance our lifestyles and build Cog­ni­tive Reserve

Lifestyle mat­ters: “The more com­plex our lives are, the more we need sim­ple things that can ground us and help us to be more resilient – to rebal­ance and rebal­ance and rebal­ance again. Build­ing the men­tal mus­cles to find bal­ance when one gets off bal­ance is a crit­i­cal skill thrive and to build cog­ni­tive reserve in our fast-chang­ing times. As our month­ly gath­er­ings showed us over the years, prac­tic­ing rebal­ance in good com­pa­ny not only rein­forces neur­al path­ways and capa­bil­i­ties but also strength­ens the bonds of trust and con­fi­dence that are invalu­able to build a healthy envi­ron­ment to thrive in.”

#6. Study: Auto­mat­ed VR psy­chother­a­py can help reduce anx­i­ety and dis­tress, espe­cial­ly among those with psy­chosis and severe agoraphobia

One of the ben­e­fits of VR is that patients know they are in a sim­u­la­tion, which enables “psy­cho­log­i­cal dis­tance from prob­lem­at­ic reac­tions,” the study authors wrote. “The process of find­ing the best uses and imple­men­ta­tion meth­ods of this immer­sive tech­nol­o­gy at scale in men­tal health is only beginning.”

#7. Fund­ing for dig­i­tal health start-ups, espe­cial­ly in men­tal health, fall sub­stan­tial­ly in Q1’22

“While all tech sec­tors received small­er fund­ing totals than the pre­vi­ous quar­ter, dig­i­tal health plunged much fur­ther than oth­ers did … investor inter­est in men­tal health tech wavered as the mar­ket and pub­lic com­pa­nies like Talk­space and Cere­bral come under scrutiny.”

#8. Deep learn­ing mod­el built on neu­roimag­ing data iden­ti­fies “Brain Age Gaps” as mark­ers of Alzheimer’s dis­ease (AD)

“The main find­ing of our study is that we could indeed find evi­dence that high brain age gap is behav­ing as an accel­er­at­ed brain aging bio­mark­er.” — Dr. David Jones, neu­rol­o­gist at Mayo Clinic

Final­ly, a cou­ple fun brain teasers to help you flex your math/ cog­ni­tive men­tal muscles:

#9. Will you fin­ish your the­sis on time?

#10. Math brain teas­er requir­ing no math — just per­cep­tion and cognition

 

Wish­ing you and yours a healthy and stim­u­lat­ing June!

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Filed Under: Brain/ Mental Health, SharpBrains Monthly eNewsletter, Technology & Innovation Tagged With: apps, biomarker, brain age gaps, brain aging biomarker, Brain Teasers, brain-aging, cognitive, digital health, digital therapeutics, mental health, mental muscles, mental-fitness, sleep, virtual-reality

Systematic review calls for early targeted interventions to help babies and toddlers with cerebral palsy harness time window with maximum brain plasticity

July 2, 2021 by SharpBrains

Ear­ly tar­get­ed inter­ven­tion ‘crit­i­cal’ for improv­ing out­comes in cere­bral pal­sy (Healio):

Ear­ly inter­ven­tion for chil­dren with or at high risk for cere­bral pal­sy should begin “as soon as pos­si­ble” in order to build on “a crit­i­cal devel­op­men­tal time,” accord­ing to results of a sys­tem­at­ic review pub­lished in JAMA Pedi­atrics. [Read more…] about Sys­tem­at­ic review calls for ear­ly tar­get­ed inter­ven­tions to help babies and tod­dlers with cere­bral pal­sy har­ness time win­dow with max­i­mum brain plasticity

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Filed Under: Brain/ Mental Health, Education & Lifelong Learning Tagged With: Attention-Deficit, autism spectrum disorder, Brain-Plasticity, Cerebral palsy, cognitive-skills, disabilities, early intervention, intellectual disability, language impairment, Neurodevelopmental, neurodevelopmental disabilities, neuroplasticity, sleep, speech

New book outlines the five lifestyle pillars to “build a better brain at any age”

May 14, 2021 by Greater Good Science Center

Like many peo­ple over 60, I some­times lose my keys or for­get the names of favorite films. When I do, it makes me won­der: Is this the begin­ning of cog­ni­tive decline? Or, worse, am I fat­ed to fol­low in the foot­steps of my moth­er, who died of Lewy-body demen­tia in her 70s?

Accord­ing to neu­ro­sur­geon San­jay Gup­ta, CNN med­ical cor­re­spon­dent and author of the new book Keep Sharp: Build­ing a Bet­ter Brain at Any Age, the answer is no. For­get­ful­ness is nor­mal at all ages, and your genes don’t doom you to demen­tia. What’s impor­tant is tak­ing care of your brain in the best way pos­si­ble, he argues.

“You can affect your brain’s think­ing and mem­o­ry far more than you real­ize or appre­ci­ate, and the vast major­i­ty of peo­ple haven’t even begun to try,” he writes.

Gup­ta dis­tills results from hun­dreds of research stud­ies to help read­ers under­stand what’s known (and not known) [Read more…] about New book out­lines the five lifestyle pil­lars to “build a bet­ter brain at any age”

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Filed Under: Brain/ Mental Health, Education & Lifelong Learning Tagged With: brain health, brain resiliency, Brain-Fitness, cognitive decline, cognitive strengths, cognitive-abilities, cognitive-capacities, cognitive-reserve, dementia, exercise, forgetfulness, keep sharp, Lifelong-learning, lifestyle, Mediterranean-like diet, memory lapses, Sanjay Gupta, sleep

Tip: To manage stress, sleep better. To sleep better, keep a good routine and manage stress.

January 4, 2021 by Greater Good Science Center

Dis­rupt­ed rou­tines and wor­ries about coro­n­avirus have made it hard­er for us to sleep this year. For exam­ple, reports sug­gest there was a 15% increase in pre­scrip­tions for sleep med­ica­tion pre­scrip­tions at the begin­ning of the pan­dem­ic in the U.S., and a 37% increase in insom­nia in China.

Impor­tant­ly, if you’ve been feel­ing out of sorts over the past few months, the lack of sleep could be part­ly to blame. [Read more…] about Tip: To man­age stress, sleep bet­ter. To sleep bet­ter, keep a good rou­tine and man­age stress.

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Filed Under: Brain/ Mental Health Tagged With: emotionally, Emotions, improving sleep, insomnia, psychologically, sleep, Stress

The latest on Brain Health and Resilience, plus a few fun Brain Teasers

November 30, 2020 by SharpBrains

Wel­come to a new edi­tion of Sharp­Brains’ e‑newsletter, fea­tur­ing fas­ci­nat­ing neu­ro­science find­ings and tips, com­bined with fun brain teasers.

#1. To cel­e­brate this quite-chal­leng­ing Thanks­giv­ing, here are five fun brain teasers that read­ers have enjoyed the most this year so far. It is always good to learn more about (and appre­ci­ate) that most pre­cious resource we all (yes, all) have up there! Five fun brain teasers to thank evo­lu­tion for our human brains and minds

#2. Want more? Ready, Set, Go! A few brain teasers to flex those cog­ni­tive muscles

#3. “[Breath­ing tech­niques] are allow­ing you to con­scious­ly take con­trol of your breath­ing so you can take con­trol of your ner­vous sys­tem so you can take con­trol of your anx­i­ety” — James Nestor, author of Breath: The New Sci­ence of a Lost Art. New book shares sci­ence and tech­niques to breathe bet­ter and pro­mote calm­ness not anxiety

#4. Voice does matter…especially in areas of poten­tial dis­agree­ment. To call, or to text, that is the (men­tal well-being) question

#5. Fas­ci­nat­ing research + inno­va­tion event brought by the Euro­pean Insti­tute of Inno­va­tion & Tech­nol­o­gy (EIT) and mul­ti­ple part­ners. Save the Date: Pro­mot­ing Brain Health for Life, Decem­ber 15–16th, online.

#6. “This isn’t a bat­tle between AI and doc­tors, it’s about how to opti­mize doc­tors’ abil­i­ty to deliv­er bet­ter care” — P. Murali Doraiswamy, direc­tor of the Neu­rocog­ni­tive Dis­or­ders Pro­gram at Duke Uni­ver­si­ty. Next: Ana­lyz­ing typ­ing speed, speech and sleep pat­terns to iden­ti­fy cog­ni­tive decline, demen­tia, Parkinson’s, and more

#7. Google’s X team shares 3 valu­able lessons learned from their ambi­tious and (for the time being) unsuc­cess­ful moon­shot: Alphabet’s X shares Amber EEG sys­tem to expand the quest for men­tal health biomarkers

#8. “An exer­cise pre­scrip­tion is an impor­tant treat­ment option and a great adjunct to med­ica­tions. The key is pre­scrib­ing phys­i­cal activ­i­ty in a way that the patient will com­ply and remain engaged with.” Debate: How should doc­tors pre­scribe exer­cise to ensure com­pli­ance and engagement?

#9. As the study authors note, “The expan­sion of women into the labor force in the mid-20th cen­tu­ry may have pro­vid­ed a new avenue of cog­ni­tive reserve for women via enhanced social stim­u­la­tion and cog­ni­tive engage­ment.” Study: Work in adult­hood seen to sig­nif­i­cant­ly delay mem­o­ry decline after age 60, sup­port­ing the Cog­ni­tive Reserve theory

#10. “Through­out many sub­red­dits, we found sig­nif­i­cant increas­es in the use of tokens relat­ed to iso­la­tion (eg, “lone­ly,” “can’t see any­one,” “quar­an­tine”), eco­nom­ic stress (eg, “rent,” “debt,” “pay the bills”), and home (“fridge,” “pet,” “lease”), and a decrease in the lex­i­con relat­ed to motion (eg, “walk,” “vis­it,” “trav­el”).” Hope­ful­ly the promis­ing vac­cine news helps turn the tide; until then we need to pro­mote men­tal health & resilience hard. Using Red­dit as a pop­u­la­tion-lev­el “men­tal health track­er” dur­ing the COVID pandemic

#11. “BCI devices can be non-inva­sive devices that users wear, or they can be inva­sive devices, which are sur­gi­cal­ly implant­ed,” says Veljko Dublje­vi … “The inva­sive devices are more effi­cient, since they can read sig­nals direct­ly from the brain. How­ev­er, they also raise more eth­i­cal con­cerns. For exam­ple, inva­sive BCI tech­nolo­gies car­ry more asso­ci­at­ed risks such as surgery, infec­tion, and glial scar­ring — and inva­sive BCI devices would be more dif­fi­cult to replace as tech­nol­o­gy improves.” Stud­ies iden­ti­fy key eth­i­cal con­cerns raised by inva­sive and non-inva­sive neurotechnologies

#12. “(the app) uses the Watch’s sen­sors to track the heart rate and move­ment of users as they sleep. After estab­lish­ing a base­line pro­file for the patient with­in one or two nights’ sleep, the machine learn­ing algo­rithm spots heart rate or move­ment abnor­mal­i­ties pre­sum­ably caused by a night­mare. The appli­ca­tion then vibrates the smart­watch just enough to inter­rupt the wearer’s dream­ing, but not enough to wake them up or dis­rupt their cir­ca­di­an sleep cycle.” FDA grants clear­ance for Night­Ware app designed to reduce PTSD-relat­ed nightmares

 

Wish­ing you a safe and healthy December,

Alvaro Fer­nan­dez and the Sharp­Brains Team

 

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Filed Under: Brain Teasers, Brain/ Mental Health, Education & Lifelong Learning, Peak Performance, Technology & Innovation Tagged With: AI, anxiety, BCI, biomarker, Brain Teasers, Breathing, cognitive engagement, cognitive-reserve, disorders, doctors, EIT, European Institute of Innovation & Technology, exercise, FDA, Google, mental health, Moonshot, neurocognitive, neuroscience, prescription, Reddit, resilience, sleep, smartwatch, Thanksgiving, voice

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