sleep

Alto Neuroscience raises $60M (equity + credit) to help fix the “trial and error” approach to psychiatric medication

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Alto Neu­ro­science bags $25M for four Phase II drugs (End­points News):

Anoth­er $25 mil­lion is flow­ing the way of a Cal­i­for­nia biotech attempt­ing to fix the “tri­al and error” sys­tem in neu­ro­science drug R&D.

Alto Neu­ro­science picked up the cap­i­tal from Alpha Wave Ven­tures via an exten­sion to its Series B, bring­ing total equi­ty raised to $100 mil­lion since the startup’s 2019 found­ing. [Read more…] about Alto Neu­ro­science rais­es $60M (equi­ty + cred­it) to help fix the “tri­al and error” approach to psy­chi­atric medication

On mental fitness beliefs, lifestyles and new tools like apps, digital therapeutics, virtual reality, “brain age gaps” and more

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Wel­come to a new edi­tion of Sharp­Brains’ e‑newsletter, fea­tur­ing time­ly brain & men­tal health news and a fun cou­ple of math brain teasers.

#1. Study on the “ABCs of Men­tal Health” finds that sim­ply believ­ing you can improve men­tal well­be­ing helps actu­al­ly improve it

Beliefs mat­ter.

#2. “Dig­i­tal ther­a­peu­tics” vs. “Men­tal health apps”: A grow­ing debate on stan­dards, reg­u­la­tion and efficacy

Def­i­n­i­tions matter.

#3. How ’sleep­ing on it’ can help the pre­frontal cor­tex reg­u­late emo­tion­al respons­es, mak­ing us feel bet­ter in the morning

Sleep mat­ters.

#4. NICE in the UK issues rec­om­men­da­tion for Sleepio app, the dig­i­tal cog­ni­tive behav­iour­al ther­a­py for insom­nia by Big Health

Inno­va­tion mat­ters: “At a price of £45 per per­son, Sleepio is cost sav­ing com­pared with usu­al treat­ment in pri­ma­ry care. This is based on an analy­sis of pri­ma­ry care resource use data before and after Sleepio was intro­duced in 9 GP prac­tices. Health­care costs were low­er at 1 year, most­ly because of few­er GP appoint­ments and sleep­ing pills prescribed.”

#5. New book pro­vides prac­ti­cal guid­ance for women (and men) to rebal­ance our lifestyles and build Cog­ni­tive Reserve

Lifestyle mat­ters: “The more com­plex our lives are, the more we need sim­ple things that can ground us and help us to be more resilient – to rebal­ance and rebal­ance and rebal­ance again. Build­ing the men­tal mus­cles to find bal­ance when one gets off bal­ance is a crit­i­cal skill thrive and to build cog­ni­tive reserve in our fast-chang­ing times. As our month­ly gath­er­ings showed us over the years, prac­tic­ing rebal­ance in good com­pa­ny not only rein­forces neur­al path­ways and capa­bil­i­ties but also strength­ens the bonds of trust and con­fi­dence that are invalu­able to build a healthy envi­ron­ment to thrive in.”

#6. Study: Auto­mat­ed VR psy­chother­a­py can help reduce anx­i­ety and dis­tress, espe­cial­ly among those with psy­chosis and severe agoraphobia

One of the ben­e­fits of VR is that patients know they are in a sim­u­la­tion, which enables “psy­cho­log­i­cal dis­tance from prob­lem­at­ic reac­tions,” the study authors wrote. “The process of find­ing the best uses and imple­men­ta­tion meth­ods of this immer­sive tech­nol­o­gy at scale in men­tal health is only beginning.”

#7. Fund­ing for dig­i­tal health start-ups, espe­cial­ly in men­tal health, fall sub­stan­tial­ly in Q1’22

“While all tech sec­tors received small­er fund­ing totals than the pre­vi­ous quar­ter, dig­i­tal health plunged much fur­ther than oth­ers did … investor inter­est in men­tal health tech wavered as the mar­ket and pub­lic com­pa­nies like Talk­space and Cere­bral come under scrutiny.”

#8. Deep learn­ing mod­el built on neu­roimag­ing data iden­ti­fies “Brain Age Gaps” as mark­ers of Alzheimer’s dis­ease (AD)

“The main find­ing of our study is that we could indeed find evi­dence that high brain age gap is behav­ing as an accel­er­at­ed brain aging bio­mark­er.” — Dr. David Jones, neu­rol­o­gist at Mayo Clinic

Final­ly, a cou­ple fun brain teasers to help you flex your math/ cog­ni­tive men­tal muscles:

#9. Will you fin­ish your the­sis on time?

#10. Math brain teas­er requir­ing no math — just per­cep­tion and cognition

 

Wish­ing you and yours a healthy and stim­u­lat­ing June!

Systematic review calls for early targeted interventions to help babies and toddlers with cerebral palsy harness time window with maximum brain plasticity

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Ear­ly tar­get­ed inter­ven­tion ‘crit­i­cal’ for improv­ing out­comes in cere­bral pal­sy (Healio):

Ear­ly inter­ven­tion for chil­dren with or at high risk for cere­bral pal­sy should begin “as soon as pos­si­ble” in order to build on “a crit­i­cal devel­op­men­tal time,” accord­ing to results of a sys­tem­at­ic review pub­lished in JAMA Pedi­atrics. [Read more…] about Sys­tem­at­ic review calls for ear­ly tar­get­ed inter­ven­tions to help babies and tod­dlers with cere­bral pal­sy har­ness time win­dow with max­i­mum brain plasticity

New book outlines the five lifestyle pillars to “build a better brain at any age”

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Like many peo­ple over 60, I some­times lose my keys or for­get the names of favorite films. When I do, it makes me won­der: Is this the begin­ning of cog­ni­tive decline? Or, worse, am I fat­ed to fol­low in the foot­steps of my moth­er, who died of Lewy-body demen­tia in her 70s?

Accord­ing to neu­ro­sur­geon San­jay Gup­ta, CNN med­ical cor­re­spon­dent and author of the new book Keep Sharp: Build­ing a Bet­ter Brain at Any Age, the answer is no. For­get­ful­ness is nor­mal at all ages, and your genes don’t doom you to demen­tia. What’s impor­tant is tak­ing care of your brain in the best way pos­si­ble, he argues.

“You can affect your brain’s think­ing and mem­o­ry far more than you real­ize or appre­ci­ate, and the vast major­i­ty of peo­ple haven’t even begun to try,” he writes.

Gup­ta dis­tills results from hun­dreds of research stud­ies to help read­ers under­stand what’s known (and not known) [Read more…] about New book out­lines the five lifestyle pil­lars to “build a bet­ter brain at any age”

Tip: To manage stress, sleep better. To sleep better, keep a good routine and manage stress.

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Dis­rupt­ed rou­tines and wor­ries about coro­n­avirus have made it hard­er for us to sleep this year. For exam­ple, reports sug­gest there was a 15% increase in pre­scrip­tions for sleep med­ica­tion pre­scrip­tions at the begin­ning of the pan­dem­ic in the U.S., and a 37% increase in insom­nia in China.

Impor­tant­ly, if you’ve been feel­ing out of sorts over the past few months, the lack of sleep could be part­ly to blame. [Read more…] about Tip: To man­age stress, sleep bet­ter. To sleep bet­ter, keep a good rou­tine and man­age stress.

The latest on Brain Health and Resilience, plus a few fun Brain Teasers

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Wel­come to a new edi­tion of Sharp­Brains’ e‑newsletter, fea­tur­ing fas­ci­nat­ing neu­ro­science find­ings and tips, com­bined with fun brain teasers.

#1. To cel­e­brate this quite-chal­leng­ing Thanks­giv­ing, here are five fun brain teasers that read­ers have enjoyed the most this year so far. It is always good to learn more about (and appre­ci­ate) that most pre­cious resource we all (yes, all) have up there! Five fun brain teasers to thank evo­lu­tion for our human brains and minds

#2. Want more? Ready, Set, Go! A few brain teasers to flex those cog­ni­tive muscles

#3. “[Breath­ing tech­niques] are allow­ing you to con­scious­ly take con­trol of your breath­ing so you can take con­trol of your ner­vous sys­tem so you can take con­trol of your anx­i­ety” — James Nestor, author of Breath: The New Sci­ence of a Lost Art. New book shares sci­ence and tech­niques to breathe bet­ter and pro­mote calm­ness not anxiety

#4. Voice does matter…especially in areas of poten­tial dis­agree­ment. To call, or to text, that is the (men­tal well-being) question

#5. Fas­ci­nat­ing research + inno­va­tion event brought by the Euro­pean Insti­tute of Inno­va­tion & Tech­nol­o­gy (EIT) and mul­ti­ple part­ners. Save the Date: Pro­mot­ing Brain Health for Life, Decem­ber 15–16th, online.

#6. “This isn’t a bat­tle between AI and doc­tors, it’s about how to opti­mize doc­tors’ abil­i­ty to deliv­er bet­ter care” — P. Murali Doraiswamy, direc­tor of the Neu­rocog­ni­tive Dis­or­ders Pro­gram at Duke Uni­ver­si­ty. Next: Ana­lyz­ing typ­ing speed, speech and sleep pat­terns to iden­ti­fy cog­ni­tive decline, demen­tia, Parkinson’s, and more

#7. Google’s X team shares 3 valu­able lessons learned from their ambi­tious and (for the time being) unsuc­cess­ful moon­shot: Alphabet’s X shares Amber EEG sys­tem to expand the quest for men­tal health biomarkers

#8. “An exer­cise pre­scrip­tion is an impor­tant treat­ment option and a great adjunct to med­ica­tions. The key is pre­scrib­ing phys­i­cal activ­i­ty in a way that the patient will com­ply and remain engaged with.” Debate: How should doc­tors pre­scribe exer­cise to ensure com­pli­ance and engagement?

#9. As the study authors note, “The expan­sion of women into the labor force in the mid-20th cen­tu­ry may have pro­vid­ed a new avenue of cog­ni­tive reserve for women via enhanced social stim­u­la­tion and cog­ni­tive engage­ment.” Study: Work in adult­hood seen to sig­nif­i­cant­ly delay mem­o­ry decline after age 60, sup­port­ing the Cog­ni­tive Reserve theory

#10. “Through­out many sub­red­dits, we found sig­nif­i­cant increas­es in the use of tokens relat­ed to iso­la­tion (eg, “lone­ly,” “can’t see any­one,” “quar­an­tine”), eco­nom­ic stress (eg, “rent,” “debt,” “pay the bills”), and home (“fridge,” “pet,” “lease”), and a decrease in the lex­i­con relat­ed to motion (eg, “walk,” “vis­it,” “trav­el”).” Hope­ful­ly the promis­ing vac­cine news helps turn the tide; until then we need to pro­mote men­tal health & resilience hard. Using Red­dit as a pop­u­la­tion-lev­el “men­tal health track­er” dur­ing the COVID pandemic

#11. “BCI devices can be non-inva­sive devices that users wear, or they can be inva­sive devices, which are sur­gi­cal­ly implant­ed,” says Veljko Dublje­vi … “The inva­sive devices are more effi­cient, since they can read sig­nals direct­ly from the brain. How­ev­er, they also raise more eth­i­cal con­cerns. For exam­ple, inva­sive BCI tech­nolo­gies car­ry more asso­ci­at­ed risks such as surgery, infec­tion, and glial scar­ring — and inva­sive BCI devices would be more dif­fi­cult to replace as tech­nol­o­gy improves.” Stud­ies iden­ti­fy key eth­i­cal con­cerns raised by inva­sive and non-inva­sive neurotechnologies

#12. “(the app) uses the Watch’s sen­sors to track the heart rate and move­ment of users as they sleep. After estab­lish­ing a base­line pro­file for the patient with­in one or two nights’ sleep, the machine learn­ing algo­rithm spots heart rate or move­ment abnor­mal­i­ties pre­sum­ably caused by a night­mare. The appli­ca­tion then vibrates the smart­watch just enough to inter­rupt the wearer’s dream­ing, but not enough to wake them up or dis­rupt their cir­ca­di­an sleep cycle.” FDA grants clear­ance for Night­Ware app designed to reduce PTSD-relat­ed nightmares

 

Wish­ing you a safe and healthy December,

Alvaro Fer­nan­dez and the Sharp­Brains Team