side effects

Amyloid-related imaging abnormalities (ARIA) found in approximately 40% of patients taking “Alzheimer’s drug” Aduhelm

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Study: Biogen’s Aduhelm Caused Brain Swelling in Over One-Third of Study Par­tic­i­pants (Bio­Space):

Atten­tion is being focused on a side effect of Biogen’s Alzheimer’s drug, Aduhelm (adu­canum­ab). Even before its con­tro­ver­sial approval on June 7, there were cas­es of amy­loid-relat­ed imag­ing abnor­mal­i­ties (ARIA‑E), or cere­bral ede­ma, observed in the tri­als. [Read more…] about Amy­loid-relat­ed imag­ing abnor­mal­i­ties (ARIA) found in approx­i­mate­ly 40% of patients tak­ing “Alzheimer’s drug” Aduhelm

Debate: Can mindfulness and meditation be harmful?

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Yes (in per­haps 8% of indi­vid­u­als). Can mind­ful­ness and med­i­ta­tion be harm­ful? (Sci­ence Focus):

Med­i­ta­tion has escaped both the reli­gious cells of monks and nuns and the labs of sci­en­tists. An increas­ing num­ber of peo­ple are using med­i­ta­tion apps to deal with men­tal health prob­lems, such as depres­sion and anx­i­ety. Although there is no clear esti­mate of how many peo­ple are prac­tis­ing med­i­ta­tion, last year one sin­gle app had close to 40 mil­lion down­loads. [Read more…] about Debate: Can mind­ful­ness and med­i­ta­tion be harmful?

Update: A life of cognitive and physical exercise helps you stay sharp in your 70s and beyond

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Wel­come to a new edi­tion of Sharp­Brains’ e‑newsletter, fea­tur­ing 13 fas­ci­nat­ing brain research find­ings, use­ful resources–and a brain teas­er to test your atten­tion skills.

#1. Good news of the month: Elders today are in sig­nif­i­cant­ly bet­ter shape–physically and cognitively–than three decades ago

#2. A dis­tinc­tion WITH a dif­fer­ence: Actu­al, sus­tained practice–not mere knowledge–is need­ed to har­ness neu­ro­plas­tic­i­ty and improve cog­ni­tion over time

#3. “Be mind­ful that with the rapid changes we are expe­ri­enc­ing, our brains are going through accel­er­at­ed learn­ing. Our brains get tired just as our bod­ies would if we ran a marathon with­out train­ing.” How COVID-relat­ed stress can dis­rupt your brain cir­cuits and nine tips to pre­vent it

#4. Yes, Yes, and Yes. To har­ness our best selves, “Tem­per your empa­thy, train your com­pas­sion, and avoid the news”

#5. Things start ear­ly. Marsh­mal­low Test with a twist: 3- and 4‑year-olds kids dis­play more self-con­trol when their rep­u­ta­tion is at stake

#6. Which is why we look for­ward to see­ing 9,000+ stu­dents, plus their many teach­ers and admin­is­tra­tors, fur­ther devel­op their unique brains and minds in years ahead: Help­ing shape the future of life­long learn­ing via SEK Edu­ca­tion Group

#7. “… it would cer­tain­ly be pre­ma­ture to sug­gest that mov­ing to a high alti­tude state would improve a child’s ADHD symp­toms. How­ev­er, the find­ings high­light the val­ue of keep­ing an open mind in efforts to under­stand the devel­op­ment of ADHD and the role nat­ur­al envi­ron­ments may play in poten­tial­ly alle­vi­at­ing it.” Study finds sur­pris­ing cor­re­la­tion between states’ ele­va­tion and ADHD prevalence

#9. Time to start pay­ing seri­ous atten­tion to the brain/ cog­ni­tive side effects of com­mon med­ica­tions. Anti­cholin­er­gic drugs found to sig­nif­i­cant­ly increase risk of cog­ni­tive decline, espe­cial­ly among those with Alzheimer’s Dis­ease bio­mark­ers or genet­ic predisposition

#10. Fas­ci­nat­ing: “After a 14-day train­ing peri­od … visu­ospa­tial skills improved by 40%. This increase in visu­ospa­tial abil­i­ty was shown to be direct­ly respon­si­ble for a reduc­tion in motion sick­ness by 51% in the sim­u­la­tor … and a 58% reduc­tion in the on-road tri­al.” Study: Self-dri­ving cars will increase motion sickness…unless we retrain our brains to improve visu­ospa­tial skills

#11. Behav­ioral health and neu­ro­plas­tic­i­ty meet big phar­ma to hope­ful­ly address a huge need. Click Ther­a­peu­tics and Boehringer Ingel­heim part­ner to devel­op and mar­ket a dig­i­tal ther­a­peu­tic to treat schizophrenia

#12. Neu­ralink: Thumbs up or down?

#13. Brain teas­er: Did you notice the numer­i­cal error as it hap­pened? If not, feel free to go back and find it now 🙂

 

Wish­ing you a safe and healthy October,

 

Alvaro Fer­nan­dez and the Sharp­Brains Team

Next: Targeted neurotechnology to augment–perhaps even take over–neuropharmacology

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deep-brain-stimulationNeu­rotech­nol­o­gy offers new solu­tions to treat­ing brain dis­eases (Dell Tech Culture):

“A new wave of med­ical tech­nolo­gies is chang­ing the way we approach study­ing the brain and treat­ing patients suf­fer­ing from neu­ro­log­i­cal dis­eases and men­tal illness.

For peo­ple suf­fer­ing from Parkinson’s, epilep­sy, OCD and severe depres­sion, these tech­no­log­i­cal advance­ments are [Read more…] about Next: Tar­get­ed neu­rotech­nol­o­gy to augment–perhaps even take over–neuropharmacology

Misuse & Abuse of ADHD Meds among college students: Updated review of a growing concern

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amphetamine-moleculeThe mis­use and abuse of pre­scrip­tion med­ica­tion is a grow­ing con­cern. I remem­ber speak­ing with col­leagues 15–20 years ago as reports about the non­med­ical use of stim­u­lant med­ica­tions used to treat ADHD (non­med­ical use is defined as use by indi­vid­u­als with­out a pre­scrip­tion) were first appear­ing in the media. At the time, these were gen­er­al­ly thought to be iso­lat­ed inci­dents that were being over-dra­ma­tized in the press. [Read more…] about Mis­use & Abuse of ADHD Meds among col­lege stu­dents: Updat­ed review of a grow­ing concern