severe depression

Study: Personalized, closed-loop neuromodulation can (one day) become a “pacemaker for the brain”

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Click image above to watch 2‑minute video explain­ing the study

Treat­ing Severe Depres­sion with On-Demand Brain Stim­u­la­tion (UCSF press release):

UCSF Health physi­cians have suc­cess­ful­ly treat­ed a patient with severe depres­sion by tap­ping into the spe­cif­ic brain cir­cuit involved in depres­sive brain pat­terns and reset­ting them using the equiv­a­lent of a pace­mak­er for the brain.

“This study points the way to a new par­a­digm that is des­per­ate­ly need­ed in psy­chi­a­try,” said Andrew Krys­tal, PhD, pro­fes­sor of psy­chi­a­try and mem­ber of the UCSF Weill Insti­tute for Neu­ro­sciences. “We’ve devel­oped a pre­ci­sion-med­i­cine approach that has suc­cess­ful­ly man­aged our patient’s treat­ment-resis­tant depres­sion by iden­ti­fy­ing and mod­u­lat­ing the cir­cuit in her brain that’s unique­ly asso­ci­at­ed with her symp­toms.” [Read more…] about Study: Per­son­al­ized, closed-loop neu­ro­mod­u­la­tion can (one day) become a “pace­mak­er for the brain”

Reinventing depression treatment via transcranial magnetic brain stimulation (TMS)

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Deirdre Lehman with Nolan Williams, who over­saw this clin­i­cal tri­al of a poten­tial treat­ment that uses tran­scra­nial mag­net­ic stim­u­la­tion. In the pho­to, Williams and Lehman demon­strate how a patient is posi­tioned and the equip­ment is used. Cred­it: Steve Fisch.

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Stan­ford researchers devise treat­ment that relieved depres­sion in 90% of par­tic­i­pants in small study (press release):

“A new form of mag­net­ic brain stim­u­la­tion rapid­ly relieved symp­toms of severe depres­sion in 90% of par­tic­i­pants in a small study con­duct­ed by researchers at the Stan­ford Uni­ver­si­ty School of Med­i­cine … In tran­scra­nial mag­net­ic stim­u­la­tion, elec­tric cur­rents from a mag­net­ic coil placed on the scalp excite a region of the brain impli­cat­ed in depres­sion. The treat­ment, as approved by the FDA, requires [Read more…] about Rein­vent­ing depres­sion treat­ment via tran­scra­nial mag­net­ic brain stim­u­la­tion (TMS)

Ethical issues raised around deep brain stimulation (DBS) research

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Researchers grap­ple with the ethics of test­ing brain implants (Sci­ence):

“In 2003, neu­rol­o­gist Helen May­berg of Emory Uni­ver­si­ty in Atlanta began to test a bold, exper­i­men­tal treat­ment for peo­ple with severe depres­sion, which involved implant­i­ng met­al elec­trodes deep in the brain in a region called area 25. The ini­tial data were promis­ing; even­tu­al­ly, they con­vinced a device com­pa­ny, St. Jude Med­ical in Saint Paul, to spon­sor a 200-per­son clin­i­cal tri­al dubbed BROADEN.

This month, how­ev­er, [Read more…] about Eth­i­cal issues raised around deep brain stim­u­la­tion (DBS) research

Next: Targeted neurotechnology to augment–perhaps even take over–neuropharmacology

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deep-brain-stimulationNeu­rotech­nol­o­gy offers new solu­tions to treat­ing brain dis­eases (Dell Tech Culture):

“A new wave of med­ical tech­nolo­gies is chang­ing the way we approach study­ing the brain and treat­ing patients suf­fer­ing from neu­ro­log­i­cal dis­eases and men­tal illness.

For peo­ple suf­fer­ing from Parkinson’s, epilep­sy, OCD and severe depres­sion, these tech­no­log­i­cal advance­ments are [Read more…] about Next: Tar­get­ed neu­rotech­nol­o­gy to augment–perhaps even take over–neuropharmacology