psychedelics

Mapping ‘psychedelic trips’ in the brain to better direct their therapeutic effects

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Image cred­it: Shutterstock

For the past sev­er­al decades, psy­che­delics have been wide­ly stig­ma­tized as dan­ger­ous ille­gal drugs. But a recent surge of aca­d­e­m­ic research into their use to treat psy­chi­atric con­di­tions is spurring a recent shift in pub­lic opinion.

Psy­che­delics are psy­chotrop­ic drugs: sub­stances that affect your men­tal state. Oth­er types of psy­chotrop­ics include anti­de­pres­sants and anti-anx­i­ety med­ica­tions. Psy­che­delics and oth­er types of hal­lu­cino­gens, how­ev­er, are unique in their abil­i­ty to tem­porar­i­ly induce intense hal­lu­ci­na­tions, emo­tions and dis­rup­tions of self-aware­ness. [Read more…] about Map­ping ‘psy­che­del­ic trips’ in the brain to bet­ter direct their ther­a­peu­tic effects

Top 10 Mental Health Innovations to Watch: Special SciAm/ WEF report

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Cred­it: Adobe

The World Eco­nom­ic Forum’s Glob­al Future Coun­cil on Men­tal Health, com­pris­ing some of the fore­most lead­ers in men­tal health, tech­nol­o­gy, infor­mat­ics, busi­ness, pub­lic pol­i­cy and advo­ca­cy is pub­lish­ing its selec­tions for the Top 10 Inno­va­tions in Men­tal Health. The ini­tia­tive is in part­ner­ship with Sci­en­tif­ic Amer­i­can, which is pub­lish­ing arti­cles by these lead­ers on its website.

Dr. Murali Doraiswamy, Coun­cil co-chair and pro­fes­sor of psy­chi­a­try at Duke Uni­ver­si­ty School of Med­i­cine notes that “the coun­cil sift­ed through more than 60 nom­i­na­tions to pick nov­el solu­tions with the high­est near-term poten­tial to impact glob­al men­tal health”.

The Top 10 Inno­va­tions select­ed are: [Read more…] about Top 10 Men­tal Health Inno­va­tions to Watch: Spe­cial SciAm/ WEF report

On building better brains at any age, treating Depression vs. Dementia, emerging neurotechnologies, psychedelics, and more

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Wel­come to a new edi­tion of Sharp­Brains’ e‑newsletter, fea­tur­ing eleven new research find­ings and inno­v­a­tive resources for life­long cog­ni­tive and brain health.

#1. Debate: Are depres­sion and demen­tia two sides of the same coin? And, if they are, how to best approach treatment?

#2. Either way, the ear­li­er the bet­ter, but it’s nev­er too late: New book out­lines the five lifestyle pil­lars to “build a bet­ter brain at any age”

#3. “If I were a car­di­ol­o­gist eval­u­at­ing a patient’s chest pain, for instance, I would speak with the patient, but then I would lis­ten to their heart and mea­sure their pulse and blood pres­sure. I might order an elec­tro­car­dio­gram or a car­diac stress test, tools that weren’t avail­able a cen­tu­ry ago. Because I’m a psy­chi­a­trist, how­ev­er, I eval­u­ate patients in pre­cise­ly the same way that my pre­de­ces­sors did in 1920…” Read­ing Our Minds: New book issues strong call to action to mod­ern­ize psychiatry

#4. Very time­ly effort by Well­come in the UK: Com­pre­hen­sive research review iden­ti­fies most promis­ing inter­ven­tions to boost work­place men­tal health

#5. “As we enter the sec­ond year of the pan­dem­ic, so many peo­ple are strug­gling and seek­ing men­tal health sup­port. Wysa is an exam­ple of how tech­nol­o­gy is help­ing mil­lions of peo­ple access every­day men­tal health sup­port and self-care tools with­out being gat­ed by a clin­i­cal diag­no­sis.” — Dr. Pankaj Jeth­wani, Exec­u­tive Vice Pres­i­dent at W Health Ven­tures. Arti­fi­cial Intel­li­gence (AI)-enabled chat­bot Wysa rais­es $5.5M to broad­en access to men­tal health support

#6. Study: Social media and gen­er­al tech engage­ment not found to “fry” teenagers’ brains

#7. Akili Inter­ac­tive Labs rais­es $160M in equi­ty and debt to trans­form cog­ni­tive health­care via pre­scrip­tion videogame treat­ments. A nice way to cel­e­brate Akil­i’s 10th anniver­sary … they are tar­get­ing ADHD first (now kids, lat­er teens and adults), to be fol­lowed by treat­ments for a range of cog­ni­tive dis­or­ders relat­ed to depres­sion, Mul­ti­ple Scle­ro­sis, Autism, “Covid-Fog” and more.

#8. Study: High­er men­tal well­be­ing (in 2016) seen to low­er health­care costs (in 2017). We still have time to invest in pub­lic men­tal well­be­ing in 2021.

#9. Teladoc Health, hav­ing acquired Livon­go and myS­trength, launch­es inte­grat­ed men­tal health ser­vice for the work­place. “The announce­ment comes as more than half of peo­ple with men­tal health con­cerns report that they do not know where to start when get­ting care, high­light­ing the impor­tance of the dig­i­tal front door myS­trength Com­plete will pro­vide…” This is indeed a very com­mon pain point accord­ing to our own research, so good to see the quite com­pre­hen­sive & per­son­al­ized approach.

#10. Cumu­lus Neu­ro­science rais­es $8.3M to devel­op EEG-based wire­less ‘Fit­bit for the brain’ — Fas­ci­nat­ing to see the major role of the Demen­tia Dis­cov­ery Fund, in a bid to accel­er­ate clin­i­cal tri­als and poten­tial therapies.

#11. Last but not least, a very promis­ing clin­i­cal appli­ca­tion of psy­che­delics: Study finds MDMA-assist­ed ther­a­py to be safe and high­ly effec­tive to treat severe PTSD. “The Nature authors spec­u­late that MDMA-assist­ed ses­sions pro­duce a “win­dow of tol­er­ance,” in which patients are able to revis­it trau­mat­ic mem­o­ries, with less shame and anger, and with­out being over­whelmed by PTSD symptoms.”

Wish­ing you a healthy Memo­r­i­al Week­end and month of June,

The Sharp­Brains Team

Study finds MDMA-assisted therapy to be safe and highly effective to treat severe PTSD

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The First Phase 3 Suc­cess for Psy­che­delics Will Pave the Way for an Indus­try (Bar­ron’s):

Post-trau­mat­ic stress dis­or­der is a crip­pling, hard-to-treat psy­chi­atric afflic­tion. Amer­i­ca spends bil­lions of dol­lars year­ly just on the vet­er­ans who suf­fer from PTSD. So it’s heart­en­ing to see the report of a promis­ing new treat­ment, pub­lished Mon­day in Nature Med­i­cine. [Read more…] about Study finds MDMA-assist­ed ther­a­py to be safe and high­ly effec­tive to treat severe PTSD

On Brain Awareness Week, mental health innovation, tDCS, biofeedback, psychedelics, and more

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Wel­come to a new edi­tion of Sharp­Brains’ e‑newsletter, start­ing with some ideas to get in the mood for Brain Aware­ness Week next month (March 15–21st). May BAW 2021 be a hun­dred times more upbeat than last year’s…

#1. Sev­en brain teasers and a neu­ro­plas­tic­i­ty pod­cast to cel­e­brate Brain Aware­ness Week 2021

#2. Imag­ine what this capa­bil­i­ty may mean just a few years from now. Should/ will Google alert Gmail users about their (future) cog­ni­tive sta­tus? Study: Arti­fi­cial intel­li­gence pro­gram iden­ti­fies lin­guis­tic mark­ers that pre­dict, with 70% accu­ra­cy, who gets Alzheimer’s Dis­ease years later

#3. Sim­i­lar to what hap­pened to Thync back in 2016, Halo Neu­ro­science strug­gled to com­mer­cial­ize tDCS as a non-med­ical device and the tech­nol­o­gy is being repur­posed for clin­i­cal use. Neu­ro­mod­u­la­tion devel­op­er Halo Neu­ro­science clos­es its doors; Flow Neu­ro­science acquires assets

#4. Here you have a cou­ple recent meta-analy­ses sug­gest­ing a grow­ing adop­tion in the near future of web-based, and increas­ing­ly per­son­al­ized, inter­ven­tions. Grow­ing research points to expand­ing adop­tion of online cog­ni­tive behav­ioral ther­a­pies, both guid­ed and unguided

#5. “If there is any­thing we’ve seen out of this year, it’s real­ly become that fourth pil­lar of ben­e­fits for every employ­er out there. Every­one has med­ical, den­tal and vision. Men­tal health has now real­ly become that fourth pil­lar of ben­e­fits for all employ­ers.” — Alyson Wat­son, CEO and founder of Mod­ern Health. Four trends accel­er­at­ing men­tal health inno­va­tion in the COVID/ post-COVID era

#6. “Access to men­tal health­care is a human right that shouldn’t be buried by stig­ma, lack of access, or afford­abil­i­ty.” — Oliv­er Har­ri­son, CEO of Koa Health. Dig­i­tal men­tal health start-up Koa Health rais­es €30M to accel­er­ate growth in Europe and the US

#7. “Just as the viral pan­dem­ic has accel­er­at­ed vac­cine devel­op­ment, this glob­al cri­sis has brought togeth­er men­tal health experts from the pub­lic and pri­vate sec­tor around the world to address what is sure­ly a sec­ond pan­dem­ic trig­gered by loss, anx­i­ety, and social iso­la­tion” — Thomas Insel, MD, co-founder of Human­est Care. Sur­vey finds con­cerns AND hope to address grow­ing men­tal health needs due to the covid pandemic

#8. Can biofeed­back-based videogames help chil­dren bet­ter man­age stress? Mag­el­lan Health and Might­i­er secure $2 mil­lion NIMH grant to investigate

#9. “The Organ­i­sa­tion for the Review of Care and Health Apps (ORCHA) has reviewed almost 600 men­tal health apps … only 29.6% meet qual­i­ty thresh­olds” The land­scape of dig­i­tal men­tal health apps: huge unmet needs, qual­i­ty con­cerns, app stores asked to ensure transparency

#10. Final­ly, an idea out there worth explor­ing … Next: Psy­che­del­ic-assist­ed psychotherapy?

Have a healthy and stim­u­lat­ing month of March,

The Sharp­Brains Team

On neuroplasticity, psychedelics, forest bathing, drinking, sleep and more: The Month in Review

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Dear read­er,

It’s time for Sharp­Brains month­ly e‑newsletter explor­ing the lat­est think­ing, sci­ence and tools for life­long brain health and men­tal well-being.

Enjoy!

New research:

New thinking:

New tools:

 

Have a great month of Sep­tem­ber, and please take a moment to share this e‑newsletter with some­one who may enjoy it 🙂

 

The Sharp­Brains Team