placebo

FDA-approved, Cybin-sponsored clinicial trial to measure ketamine’s impact on the brain via Kernel Flow neuroimaging helmet

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Kernel’s Brain-Imag­ing Hel­met Approved For Clin­i­cal Tri­al On Patients Using Ket­a­mine (Forbes):

The U.S. Food and Drug Admin­is­tra­tion has approved a clin­i­cal tri­al using a neu­roimag­ing hel­met made by Los Ange­les-based Ker­nel to track what hap­pens in the brain when a human takes a psy­che­del­ic dose of ket­a­mine. [Read more…] about FDA-approved, Cybin-spon­sored clin­i­cial tri­al to mea­sure ketamine’s impact on the brain via Ker­nel Flow neu­roimag­ing helmet

Update: The placebo effect works even when people know they are taking a placebo

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Wel­come to a new edi­tion of Sharp­Brains’ e‑newsletter, fea­tur­ing 14 research find­ings, resources and tips for brain health … and start­ing with this fas­ci­nat­ing study:

#1. Wow. The place­bo effect works even when peo­ple know they are tak­ing a placebo

#2. Beat­ing Alzheimer’s Dis­ease will require a com­bined physical/ men­tal approach: From the ten fac­tors found to increase AD risk in the most com­pre­hen­sive evi­dence review to date,

#3. “The health­i­est peo­ple are the ones who grow with age and expe­ri­ence; even in times of trou­ble like these.” — Dhar­ma Singh Khal­sa, MD, Pres­i­dent of the Alzheimer’s Research and Pre­ven­tion Foun­da­tion. On Stress, Yoga Med­i­ta­tion, and The Evo­lu­tion Revolution

#4. “Accep­tance that Alzheimer’s dis­ease is a lifestyle dis­ease, lit­tle dif­fer­ent from oth­er age-relat­ed dis­eases, that is the sum of a life­time is the most impor­tant break­through of the decade.” — George Per­ry, PhD, Edi­tor-in-Chief of the Jour­nal of Alzheimer’s Dis­ease. High­er body mass index (BMI) linked to low­er blood sup­ply to the brain in large neu­roimag­ing study

#5. “Atten­tion is a scarce resource. Think about your atten­tion­al focus as the beam of a light. If the light is on an object it can­not be on oth­er objects at the same time with the same inten­si­ty … Although we typ­i­cal­ly have the feel­ing that mul­ti­task­ing saves us time, it is often not the case.” Sim­ple, quick brain teas­er to test the lim­its of multitasking

#6. If it appears to rotate, RT ? Fun opti­cal illu­sion to tease your mind

#7. Every cloud has a sil­ver lin­ing: How and when will the telemed­i­cine surge reach men­tal healthcare?

#8. Not a minute too soon: Mag­el­lan Health is test­ing biofeed­back videogame Might­i­er to help chil­dren bet­ter self-reg­u­late stress

#9. “In a time when emo­tions like stress, anx­i­ety, bore­dom, and anger are hard to avoid, a new study sug­gests that a par­tic­u­lar med­i­ta­tion prac­tice can help us face them.” Study: Med­i­ta­tion prac­tice, both for­mal and infor­mal, helps devel­op equa­nim­i­ty over time

#10. Ever since dis­cov­er­ing Bar­bara Arrow­smith-Young’s life tra­jec­to­ry via Nor­main Doidge’s fan­tas­tic book The Brain That Changes Itself, we have been impressed by her cre­ativ­i­ty, sta­mi­na and courage. Com­ing soon: Vir­tu­al World Tour at the fron­tier of applied neu­ro­plas­tic­i­ty, edu­ca­tion and learn­ing difficulties

#11. “Neur­al sig­nals will be used to devel­op algo­rithms that will help researchers deter­mine the opti­mal brain state under which indi­vid­u­als can receive infor­ma­tion. From there, the team will deter­mine the most effec­tive means of enhanc­ing the sub­jects’ abil­i­ty to intake and process infor­ma­tion. This could range from non-inva­sive neuromodulation—or brain stimulation—techniques to the use of aug­ment­ed real­i­ty to alter per­ceived envi­ron­men­tal con­di­tions.” Air Force announces research plat­form to har­ness closed-loop neu­rotech­nol­o­gy and accel­er­ate learn­ing “on the fly”

#12. Good to hear that “ensur­ing the pri­va­cy and secu­ri­ty of study par­tic­i­pants’ data is a high pri­or­i­ty for both UCLA and Apple. UCLA will process and main­tain study data in a secure envi­ron­ment … UCLA and Apple will ana­lyze the data only after they are cod­ed and stripped of names and oth­er con­tact infor­ma­tion.” UCLA launch­es major men­tal health study col­lect­ing & ana­lyz­ing data from Apple wear­ables to bet­ter under­stand depres­sion and anxiety

#13. Flex­i­bil­i­ty is good except when it isn’t: Study finds how sci­en­tists can reach dif­fer­ent con­clu­sions ana­lyz­ing the same brain scans

#14. “I have so much to accom­plish today that I must med­i­tate for two hours instead of one” — Gand­hi, as quot­ed in Sev­en evi­dence-based rea­sons to start med­i­tat­ing yesterday

Wish­ing you a safe and healthy September,

Alvaro Fer­nan­dez on behalf of the Sharp­Brains Team

Study: The placebo effect works even when people know they are taking a placebo

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Place­bos Prove Pow­er­ful, Even When Peo­ple Know They’re Tak­ing One, New Study Sug­gests (MSU release):

How much of a treat­ment is mind over mat­ter? It is well doc­u­ment­ed that peo­ple often feel bet­ter after tak­ing a treat­ment with­out active ingre­di­ents sim­ply because they believe it’s real — known as the place­bo effect.

A team of researchers from Michi­gan State Uni­ver­si­ty, Uni­ver­si­ty of Michi­gan and Dart­mouth Col­lege is the first to demon­strate that place­bos reduce brain mark­ers of emo­tion­al dis­tress even when peo­ple know they are tak­ing one. [Read more…] about Study: The place­bo effect works even when peo­ple know they are tak­ing a placebo

Large study finds that placebo works as well as vitamin D supplements to prevent depression and improve mood

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Large Study Con­firms Vit­a­min D Does Not Reduce Risk of Depres­sion in Adults (Mass Gen­er­al press release):

Vit­a­min D sup­ple­men­ta­tion does not pro­tect against depres­sion in mid­dle-age or old­er adult­hood accord­ing results from one of the largest ever stud­ies of its kind … “There was no sig­nif­i­cant ben­e­fit from the sup­ple­ment for this pur­pose. It did not pre­vent depres­sion or improve mood,” says Olivia I. Okereke, MD, MS, of the Mass­a­chu­setts Gen­er­al Hos­pi­tal (MGH) Psy­chi­a­try Department.

[Read more…] about Large study finds that place­bo works as well as vit­a­min D sup­ple­ments to pre­vent depres­sion and improve mood

Study finds mixed results of Adderall as cognitive enhancer (seems to boost emotion more than cognition)

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Over the past 15 years there has been grow­ing aware­ness that many col­lege stu­dents with­out an ADHD diag­no­sis use ADHD drugs. On some cam­pus­es, rates of self-report­ed non-med­ical use have exceed­ed 30% of students.

The pri­ma­ry rea­son stu­dents report tak­ing ADHD drugs is to enhance their aca­d­e­m­ic per­for­mance. And, the strong major­i­ty of stu­dents — over 80% in a study I con­duct­ed — believe it is help­ful for this purpose.

Fur­ther­more, stu­dents who report prob­lems with atten­tion are more like­ly to report non-med­ical use than oth­er stu­dents; this sug­gests that some self-med­icate to address their per­ceived atten­tion dif­fi­cul­ties. [Read more…] about Study finds mixed results of Adder­all as cog­ni­tive enhancer (seems to boost emo­tion more than cognition)

On “ethical placebos,” Medicine, and Mind/ Body interactions: A book review

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Cure_bookWhen I was 10 years old, I hat­ed doing the dish­es. In an attempt to talk my par­ents out of mak­ing me do this hat­ed chore, I pre­tend­ed to be ill by hang­ing my head, sigh­ing, snif­fling, and walk­ing lethar­gi­cal­ly to my bed­room, all to no avail—I still had to do those dishes.

But, the next day, I woke up with the flu —a 104-degree fever and stom­ach pains to match. Boy, were my par­ents sur­prised! And, so was I. But, how many of us have had sim­i­lar expe­ri­ences, where our minds seemed to some­how impact our bod­ies in weird, unex­plain­able ways? How many of us have made doc­tors’ appoint­ments only to watch our fevers drop or held our chil­dren close and stopped their cough­ing fits? Clear­ly, some­thing is going on, isn’t it? [Read more…] about On “eth­i­cal place­bos,” Med­i­cine, and Mind/ Body inter­ac­tions: A book review