The first drug purporting to slow the advance of Alzheimer’s disease is likely to cost the U.S. health care system billions annually even as it remains out of reach for many of the lower-income seniors most likely to suffer from dementia.
Medicare and Medicaid patients will make up 92% of the market for lecanemab, according to Eisai Co., which sells the drug under the brand name Leqembi. In addition to the company’s $26,500 annual price tag for the drug, treatment could cost U.S. taxpayers $82,500 per patient per year, on average, for genetic tests and frequent brain scans, safety monitoring, and other care, according to estimates from the Institute for Clinical and Economic Review, or ICER. [Read more…] about Price tag for a questionable Alzheimer’s treatment: $109,000 per patient, per year. Unclear yet: For how many years?
Given the growing media coverage mentioning the terms Cognitive Reserve and Brain Reserve, you may be asking yourself, “What exactly is my Cognitive (or Brain) Reserve?”
The cognitive reserve hypothesis, tested in multiple studies, states that individuals with more cognitive reserve can experience more AlzheimerÃ¢â‚¬â„¢s disease pathology in the brain (more plaques and tangles) without developing AlzheimerÃ¢â‚¬â„¢s disease symptoms.
How does that work? Scientists are not sure but two possibilities are considered.
1. One is that more cognitive reserve means more brain reserve, that is more neurons and connections (synapses) between neurons. Individuals with more synapses would then have more synapses to lose before the critical threshold for AlzheimerÃ¢â‚¬â„¢s Disease is reached.
2. Another possibility is that more cognitive reserve means more compensatory processes. The brain of individuals with more cognitive reserve would use more alternative networks to compensate for the damages caused by the pathology in previously used networks.
In a newly published study, Roe and colleagues from Washington University in St. Louis, used the number of years of education as a measure of cognitive reserve. Why years of education? Because previous studies have shown that people who have more education also exhibit a greater resistance to AlzheimerÃ¢â‚¬â„¢s symptoms, even while pathological changes are occurring in the brain (see Bennett el al., 2003 or Roe, Xiong, et al., 2008).
Roe and her colleagues studied 198 individuals whose mean age was 67. Out of these 198 individuals, 161 were nondemented and 37 were diagnosed with AlzheimerÃ¢â‚¬â„¢s Disease.
All the participants in the study took a [Read more…] about Education builds Cognitive Reserve for Alzheimers Disease Protection