occupational attainment

Study: High Cognitive Reserve (CR) seen to significantly lower dementia risk even in the presence of high Alzheimer’s Disease (AD) neuropathology

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Fig­ure 2. Inci­dence Rates of Demen­tia per 1000 Per­son-Years by Cog­ni­tive Reserve (CR) Ter­tile and Brain Pathol­o­gy; adjust­ed for age, sex, smok­ing, alco­hol con­sump­tion, phys­i­cal activ­i­ty, body mass index, heart dis­ease, hyper­ten­sion, cere­brovas­cu­lar dis­ease, dia­betes, and apolipopro­tein E e4. AD indi­cates Alzheimer dis­ease. Source: Xu H et al (2020)

Lifes­pan Cog­ni­tive Reserve—A Secret to Cop­ing With Neu­rode­gen­er­a­tive Pathol­o­gy (JAMA Neu­rol­o­gy editorial):

Giv­en the lim­it­ed suc­cess of ther­a­peu­tic inter­ven­tions for Alzheimer dis­ease, there is increased inter­est in under­stand­ing whether mod­i­fi­able fac­tors can help cope with or post­pone the appear­ance of brain pathol­o­gy. It is esti­mat­ed that about 35% of Alzheimer risk is mod­i­fi­able. Epi­demi­o­log­ic stud­ies have shown that life­time expo­sures to high­er edu­ca­tion, high­er occu­pa­tion­al attain­ment, and cog­ni­tive­ly stim­u­lat­ing activ­i­ties are asso­ci­at­ed with reduced risk of Alzheimer demen­tia. Autop­sy stud­ies have shown interindi­vid­ual dif­fer­ences in the amount of brain pathol­o­gy peo­ple can tol­er­ate before man­i­fest­ing cog­ni­tive impair­ments, and autop­sied brains of about one-third of indi­vid­u­als who are cog­ni­tive­ly nor­mal meet neu­ropatho­log­i­cal cri­te­ria for Alzheimer dis­ease. [Read more…] about Study: High Cog­ni­tive Reserve (CR) seen to sig­nif­i­cant­ly low­er demen­tia risk even in the pres­ence of high Alzheimer’s Dis­ease (AD) neuropathology

Experience Corps: Promoting Healthy, Meaningful Aging Through Social Involvement

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The cur­rent issue of Cere­brum –a great pub­li­ca­tion of the Dana Foun­da­tion– includes the excel­lent in-depth arti­cle Pro­mot­ing Healthy, Mean­ing­ful Aging Through Social Involve­ment: Build­ing an Expe­ri­ence Corps, writ­ten by researcher Michelle Carlson:

“Over the last decade, sci­en­tists made two key dis­cov­er­ies that reframed our under­stand­ing of the adult brain’s poten­tial to ben­e­fit from life­long envi­ron­men­tal enrich­ment. First, they learned that the adult brain remains plas­tic; it can gen­er­ate new neu­rons in response to phys­i­cal activ­i­ty and new expe­ri­ences. Sec­ond, they con­firmed the impor­tance of [Read more…] about Expe­ri­ence Corps: Pro­mot­ing Healthy, Mean­ing­ful Aging Through Social Involvement