neurology

Good survey of brain stimulation methods, value and limitations

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brain_stimulationStim­u­lat­ing the Brain: From If to How (The Dana Foundation):

“Recent years have brought mod­ern meth­ods of brain stim­u­la­tion into the main­stream of neu­rol­o­gy and psy­chi­a­try. But their mechanism—how exact­ly deep brain stim­u­la­tion (DBS) relieves Parkinson’s dis­ease symp­toms and how repet­i­tive tran­scra­nial mag­net­ic stim­u­la­tion (rTMS) improves depres­sion, for example—remains obscure. Research [Read more…] about Good sur­vey of brain stim­u­la­tion meth­ods, val­ue and limitations

Beyond helmets: concussions require proactive, individualized monitoring and rehab

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footballNew Con­cus­sion Guide­lines Stress Indi­vid­ual Treat­ment (The New York Times):
“The Amer­i­can Acad­e­my of Neu­rol­o­gy said Mon­day that it had revised its guide­lines for han­dling con­cus­sions to empha­size treat­ing ath­letes case by case rather than accord­ing to a pre­de­ter­mined scale…In not­ing that more than a mil­lion Amer­i­can ath­letes [Read more…] about Beyond hel­mets: con­cus­sions require proac­tive, indi­vid­u­al­ized mon­i­tor­ing and rehab

To Harness Neuroplasticity, Start with Enthusiasm

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We are the archi­tects and builders of our own brains.

For mil­len­nia, how­ev­er, we were obliv­i­ous to our enor­mous cre­ative capa­bil­i­ties. We had no idea that our brains were chang­ing in response to our actions and atti­tudes, every day of our lives. So we uncon­scious­ly and ran­dom­ly shaped our brains and our lat­ter years because we believed we had an immutable brain that was at the mer­cy of our genes.

Noth­ing could be fur­ther from the truth. [Read more…] about To Har­ness Neu­ro­plas­tic­i­ty, Start with Enthusiasm

Research on ‘Chemo Brain’: MRI Shows Brain Changes After Chemotherapy

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‘Chemo Brain’: MRI Shows Brain Changes After Chemother­a­py (Med­scape):

- “Breast can­cer sur­vivors who have been treat­ed with chemother­a­py show sig­nif­i­cant changes in brain activ­i­ty, mea­sured by func­tion­al mag­net­ic res­o­nance imag­ing (fMRI), accord­ing to a study pub­lished in the Novem­ber issue of the Archives of Neu­rol­o­gy.”

- “The find­ing val­i­dates patients’ claims of reduced cog­ni­tive func­tion after receiv­ing chemother­a­py, a phe­nom­e­non referred to as “chemo brain,” said lead author Shel­li R. Kesler, PhD, from Stan­ford Uni­ver­si­ty School of Med­i­cine in California.”

Link to study Pre­frontal Cor­tex and Exec­u­tive Func­tion Impair­ments in Pri­ma­ry Breast Can­cer (Archives of Neu­rol­o­gy): [Read more…] about Research on ‘Chemo Brain’: MRI Shows Brain Changes After Chemotherapy

NovaVision selling assets (neuroplasticity-based Visual Restoration Therapy)

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We men­tioned in our recent mar­ket report that NovaV­i­sion had declared bank­rup­cy. The com­pa­ny tried to trans­form its busi­ness mod­el in the last cou­ple of years — obvi­ous­ly it did­n’t work. Now the trustee is shar­ing a few more details and look­ing for ways to dis­pose of its assets:

NovaVision’s FDA-Cleared Visu­al Restora­tion Ther­a­py (VRT) Sys­tem and Com­pa­ny Assets Now Avail­able (press release)

The bank­rupt­cy trustee has engaged The Mag­num Group, Inc., to solic­it offers for NovaVision’s assets which include the NovaV­i­sion Visu­al Restora­tion Ther­a­py (VRT) sys­tem, a neu­ro­plac­tic­i­ty (sic) plat­form that has been cleared by the U.S. Food and Drug Admin­is­tra­tion (FDA) for the treat­ment of stroke, trau­mat­ic brain injury, ambly­opia (“lazy eye”) and optic nerve damage.

NovaV­i­sion has received a total invest­ment of $49,200,000 since its found­ing in 2003 and has gen­er­at­ed rev­enues of approx­i­mate­ly $1,000,000 each year for the past three years. The company’s non-inva­sive com­put­er-based neu­ro­plac­tic­i­ty (sic) prod­ucts have treat­ed more than 3,000 patients world­wide. NovaV­i­sion esti­mates the total mar­ket oppor­tu­ni­ty for its port­fo­lio of prod­ucts to exceed 300,000 units in U.S. optom­e­try, oph­thal­mol­o­gy, neu­rol­o­gy, and pri­ma­ry care prac­tices as well as reha­bil­i­ta­tion centers.

Education AND Lifelong Cognitive Activities build Cognitive Reserve and Delay Memory Loss

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In a recent­ly pub­lished sci­en­tif­ic study (see Hall C, et al “Cog­ni­tive activ­i­ties delay onset of mem­o­ry decline in per­sons who devel­op demen­tia” Neu­rol­o­gy 2009; 73: 356–361), Hall and col­leagues exam­ined how edu­ca­tion and stim­u­lat­ing activ­i­ties may inter­act to con­tribute to cog­ni­tive reserve. The study involved 488 ini­tial­ly healthy peo­ple, aver­age age 79, who brain teasers job interviewenrolled in the Bronx Aging Study between 1980 and 1983. These indi­vid­u­als were fol­lowed for 5 years with assess­ments every 12 to 18 months (start­ing in 1980). At the start of the study, all par­tic­i­pants were asked how many cog­ni­tive activ­i­ties (read­ing, writ­ing, cross­word puz­zles, board or card games, group dis­cus­sions, or play­ing music) they par­tic­i­pat­ed in and for how many days a week. Researchers were able to eval­u­ate the impact of self-report­ed par­tic­i­pa­tion these activ­i­ties on the onset of accel­er­at­ed mem­o­ry decline in 101 indi­vid­u­als who devel­oped demen­tia dur­ing the study.

Results showed that for every “activ­i­ty day” (par­tic­i­pa­tion in one activ­i­ty for one day a week) the sub­jects engaged in, they delayed for about two months the onset of rapid mem­o­ry loss asso­ci­at­ed with demen­tia. Inter­est­ing­ly, the pos­i­tive effect of brain-stim­u­lat­ing activ­i­ties in this study appeared to be inde­pen­dent of a per­son­’s lev­el of education.

This is great news as it sug­gests that it is nev­er too late to try to build up brain reserve. The more brain stim­u­lat­ing activ­i­ties one does and the more often, the bet­ter for a stronger cog­ni­tive reserve.

The cog­ni­tive reserve hypoth­e­sis sug­gests that indi­vid­u­als with more cog­ni­tive reserve can expe­ri­ence more Alzheimer’s dis­ease pathol­o­gy in the brain (more plaques and tan­gles) with­out devel­op­ing Alzheimer’s dis­ease symptoms.

How does that work? Sci­en­tists are not sure but two pos­si­bil­i­ties are considered.
1. One is that more cog­ni­tive reserve means more brain reserve, that is more neu­rons and con­nec­tions between neurons.
2. Anoth­er pos­si­bil­i­ty is that more cog­ni­tive reserve means more com­pen­sato­ry process­es (see my pre­vi­ous post “Edu­ca­tion builds Cog­ni­tive Reserve for Alzheimers Dis­ease Pro­tec­tion” for more details.)

Now, one may won­der about the dif­fer­ence types of men­tal stim­u­la­tion avail­able, includ­ing not only puz­zles and such, but struc­tured activ­i­ties such as brain fit­ness soft­ware and med­i­ta­tion. Do we exer­cise our brain every time we think about some­thing? What can one do to exer­cise one’s brain in ways that enhance capac­i­ty? Does aer­o­bic fit­ness train­ing also exer­cise one’s brain? What types of method­olo­gies and prod­ucts are avail­able? Do they “work”? Are all the same?

Those are the types of ques­tions we want­ed to address in the book The Sharp­Brains Guide To Brain Fit­ness (avail­able via Amazon.com). We are proud of the recog­ni­tion the book has start­ed to obtain, includ­ing endorse­ments by lead­ing scientists:

“The Sharp­Brains Guide to Brain Fit­ness is the only book that I know of that seam­less­ly inte­grates lat­est infor­ma­tion about cog­ni­tive health across the lifes­pan, with inter­views with active researchers exam­in­ing cog­ni­tive main­te­nance and enhance­ment, along with reviews of com­mer­cial prod­ucts tar­get­ed to cog­ni­tive enhance­ment. The book should be very use­ful to any­one inter­est­ed in brain care, both health care pro­fes­sion­als and the pub­lic at large”.
— Arthur Kramer, Pro­fes­sor of Psy­chol­o­gy at Uni­ver­si­ty of Illinois

“This Sharp­Brains book pro­vides a very valu­able ser­vice to a wide com­mu­ni­ty inter­est­ed in learn­ing and brain top­ics. I found it inter­est­ing and helpful”
- Michael Pos­ner, Emer­i­tus Pro­fes­sor of Neu­ro­science at the Uni­ver­si­ty of Ore­gon, and first recip­i­ent of the Dogan Prize

Pascale Michelon– Pas­cale Mich­e­lon, Ph. D., is Sharp­Brains’ Research Man­ag­er for Edu­ca­tion­al Projects. Dr. Mich­e­lon has a Ph.D. in Cog­ni­tive Psy­chol­o­gy and has worked as a Research Sci­en­tist at Wash­ing­ton Uni­ver­si­ty in Saint Louis, in the Psy­chol­o­gy Depart­ment. She con­duct­ed sev­er­al research projects to under­stand how the brain makes use of visu­al infor­ma­tion and mem­o­rizes facts. She is now an Adjunct Fac­ul­ty at Wash­ing­ton University.

Ref­er­ences:

- Study: Hall C, et al “Cog­ni­tive activ­i­ties delay onset of mem­o­ry decline in per­sons who devel­op demen­tia” Neu­rol­o­gy 2009; 73: 356–361

- Book: The Sharp­Brains Guide To Brain Fit­ness: 18 Inter­views with Sci­en­tists, Prac­ti­cal Advice, and Prod­uct Reviews, to Keep Your Brain Sharp