JAMA

Study: High Cognitive Reserve (CR) seen to significantly lower dementia risk even in the presence of high Alzheimer’s Disease (AD) neuropathology

by

Fig­ure 2. Inci­dence Rates of Demen­tia per 1000 Per­son-Years by Cog­ni­tive Reserve (CR) Ter­tile and Brain Pathol­o­gy; adjust­ed for age, sex, smok­ing, alco­hol con­sump­tion, phys­i­cal activ­i­ty, body mass index, heart dis­ease, hyper­ten­sion, cere­brovas­cu­lar dis­ease, dia­betes, and apolipopro­tein E e4. AD indi­cates Alzheimer dis­ease. Source: Xu H et al (2020)

Lifes­pan Cog­ni­tive Reserve—A Secret to Cop­ing With Neu­rode­gen­er­a­tive Pathol­o­gy (JAMA Neu­rol­o­gy editorial):

Giv­en the lim­it­ed suc­cess of ther­a­peu­tic inter­ven­tions for Alzheimer dis­ease, there is increased inter­est in under­stand­ing whether mod­i­fi­able fac­tors can help cope with or post­pone the appear­ance of brain pathol­o­gy. It is esti­mat­ed that about 35% of Alzheimer risk is mod­i­fi­able. Epi­demi­o­log­ic stud­ies have shown that life­time expo­sures to high­er edu­ca­tion, high­er occu­pa­tion­al attain­ment, and cog­ni­tive­ly stim­u­lat­ing activ­i­ties are asso­ci­at­ed with reduced risk of Alzheimer demen­tia. Autop­sy stud­ies have shown interindi­vid­ual dif­fer­ences in the amount of brain pathol­o­gy peo­ple can tol­er­ate before man­i­fest­ing cog­ni­tive impair­ments, and autop­sied brains of about one-third of indi­vid­u­als who are cog­ni­tive­ly nor­mal meet neu­ropatho­log­i­cal cri­te­ria for Alzheimer dis­ease. [Read more…] about Study: High Cog­ni­tive Reserve (CR) seen to sig­nif­i­cant­ly low­er demen­tia risk even in the pres­ence of high Alzheimer’s Dis­ease (AD) neuropathology

To screen, or not to screen (for dementia), that is still the question

by

A lead­ing group of med­ical experts on Tues­day declined to endorse cog­ni­tive screen­ing for old­er adults, fuel­ing a debate that has sim­mered for years.

The U.S. Pre­ven­tive Ser­vices Task Force said it could nei­ther rec­om­mend nor oppose cog­ni­tive screen­ing, cit­ing insuf­fi­cient sci­en­tif­ic evi­dence of the practice’s ben­e­fits and harms and call­ing for fur­ther studies.

The task force’s work informs poli­cies set by Medicare and pri­vate insur­ers. Its rec­om­men­da­tions, an accom­pa­ny­ing sci­en­tif­ic state­ment and two edi­to­ri­als were pub­lished Tues­day in the Jour­nal of the Amer­i­can Med­ical Association.

The task force’s new posi­tion comes as con­cern mounts over a ris­ing tide of old­er adults with Alzheimer’s dis­ease and [Read more…] about To screen, or not to screen (for demen­tia), that is still the question

New studies reinforce Education and Cognitive Reserve –instead of drugs targeting beta amyloid– as most promising avenue to prolong cognitive health and reduce dementia risk

by

dementia-progressionDemen­tia Risk Declines, And Edu­ca­tion May Be One Rea­son Why (NPR):

“Some encour­ag­ing news in the bat­tle against Alzheimer’s dis­ease and oth­er forms of demen­tia: The rate at which old­er Amer­i­cans are get­ting these con­di­tions is declin­ing. That’s accord­ing to [Read more…] about New stud­ies rein­force Edu­ca­tion and Cog­ni­tive Reserve –instead of drugs tar­get­ing beta amy­loid– as most promis­ing avenue to pro­long cog­ni­tive health and reduce demen­tia risk

Study points to growing cognitive gap between high-volume TV watchers and infrequent watchers

by

watching tv adultToo Much TV And Chill Could Reduce Brain Pow­er Over Time (NPR):

“Researchers at the Uni­ver­si­ty of Cal­i­for­nia, San Fran­cis­co checked in with 3,247 peo­ple for 25 years, start­ing when they were young adults…People who got lit­tle exer­cise or watched at least three hours of TV a day did worse [Read more…] about Study points to grow­ing cog­ni­tive gap between high-vol­ume TV watch­ers and infre­quent watchers

Study: To improve memory and thinking skills, try the Mediterranean diet with added olive oil and nuts

by

Mediterranean-Diet

.

Mediter­ranean diet may help coun­ter­act age-relat­ed declines in mem­o­ry and think­ing skills (Har­vard Health Blog):

“A new study in this week’s JAMA Inter­nal Med­i­cine sug­gests that eat­ing a Mediter­ranean-style diet enhanced with extra-vir­gin olive oil or nuts is good for your mind as well as your heart. [Read more…] about Study: To improve mem­o­ry and think­ing skills, try the Mediter­ranean diet with added olive oil and nuts

Study: Cognitive Markers or Biomarkers to manage Cognitive Health across the Lifespan?

by

Pre­dict­ing Alzheimer’s Dis­ease More Accu­rate Through Cog­ni­tive Changes Than Bio­mark­ers (Med­ical News):