emotion

Alto Neuroscience raises $60M (equity + credit) to help fix the “trial and error” approach to psychiatric medication

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Alto Neu­ro­science bags $25M for four Phase II drugs (End­points News):

Anoth­er $25 mil­lion is flow­ing the way of a Cal­i­for­nia biotech attempt­ing to fix the “tri­al and error” sys­tem in neu­ro­science drug R&D.

Alto Neu­ro­science picked up the cap­i­tal from Alpha Wave Ven­tures via an exten­sion to its Series B, bring­ing total equi­ty raised to $100 mil­lion since the startup’s 2019 found­ing. [Read more…] about Alto Neu­ro­science rais­es $60M (equi­ty + cred­it) to help fix the “tri­al and error” approach to psy­chi­atric medication

Update: Playing videogames may be more cognitively beneficial than other forms of screentime like social media, watching videos/ TV

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Wel­come to a new edi­tion of Sharp­Brains’ e‑newsletter, fea­tur­ing time­ly brain & men­tal health news and a fun brain teas­er to put your tem­po­ral lobes to good use 🙂

#1. Study finds that play­ing videogames may be more cog­ni­tive­ly ben­e­fi­cial for chil­dren than oth­er forms of screen­time (social media, watch­ing videos/ TV)

“Here, we esti­mat­ed the impact of dif­fer­ent types of screen time (watch­ing, social­iz­ing, or gam­ing) on children’s intel­li­gence while con­trol­ling for the con­found­ing effects of genet­ic dif­fer­ences in cog­ni­tion and socioe­co­nom­ic sta­tus … Broad­ly, our results are in line with research on the mal­leabil­i­ty of cog­ni­tive abil­i­ties from envi­ron­men­tal fac­tors, such as cog­ni­tive train­ing and the Fly­nn effect.”

Fas­ci­nat­ing! Hav­ing said that…

#2. Large neu­roimag­ing study finds social iso­la­tion to be an ear­ly indi­ca­tor of increased demen­tia risk

“Social inter­ac­tion is huge­ly impor­tant. One study found that the size of our social group is actu­al­ly asso­ci­at­ed with the vol­ume of the orbitofrontal cor­tex (involved in social cog­ni­tion and emo­tion). But how many friends do we need? … It is hard to argue with the fact that humans are social ani­mals and gain enjoy­ment from con­nect­ing with oth­ers, what­ev­er age we are. But, as we are increas­ing­ly uncov­er­ing, it also cru­cial for the health of our cognition.”

#3. UC study finds near-trans­fer of cog­ni­tive train­ing to be nec­es­sary (yet not suf­fi­cient) for far-trans­fer, broad­er benefits

“Some peo­ple do very well in train­ing, such as play­ing a video game, but they don’t show near trans­fer, per­haps because they are using high­ly spe­cif­ic strate­gies,” said first author Anja Pahor … “For these peo­ple, far trans­fer is unlike­ly. By bet­ter under­stand­ing why this type of mem­o­ry train­ing or ‘inter­ven­tion’ works for some peo­ple but not oth­ers, we can move for­ward with a new gen­er­a­tion of work­ing-mem­o­ry train­ing games or use approach­es that are more tai­lored to indi­vid­u­als’ needs”

#4. Please help us recruit 30,000 adults for a UC Cit­i­zen Sci­ence project on cog­ni­tive training

“In our ongo­ing large-scale study (note: the one right above) we aim to recruit 30,000 adults who are moti­vat­ed and will­ing to help us bet­ter under­stand the fac­tors that under­lie learn­ing out­comes using a vari­ety of train­ing par­a­digms and out­come mea­sures. Our endeav­or will ulti­mate­ly con­tribute to the per­son­al­iza­tion of cog­ni­tive train­ing so that, hope­ful­ly, any­one who would like to improve their cog­ni­tive func­tion­ing will be able to choose the approach that may fit them best.” — researchers Susanne Jaeg­gi, Anja Pahor, Aaron Seitz @ UC Irvine/ Riverside

#5. Trend: Esports teams har­ness cog­ni­tive tests to bet­ter match play­er to task and to iden­ti­fy train­ing opportunities

Esports are bor­row­ing a page from Pro Sports’ book … we would­n’t be sur­prised to see the inverse tak­ing place too in just a few years.

#6. Dos and Don’ts of Ther­a­py on the Go: Nav­i­gat­ing the use of apps for men­tal health care

“For those with­out severe men­tal ill­ness, app-based ther­a­py may be help­ful in match­ing clients with a pro­fes­sion­al famil­iar with a range of prob­lems and stres­sors. This makes apps attrac­tive to those with anx­i­ety and mild to mod­er­ate depres­sion. They also appeal to peo­ple who wouldn’t ordi­nar­i­ly seek out office-based ther­a­py, but who want help with life issues such as mar­i­tal prob­lems and work-relat­ed stress.”

#7. AI-enabled chat­bot Wysa receives FDA Break­through Device des­ig­na­tion for patients with chron­ic pain, depres­sion and anxiety

Let’s talk!

#8. And here’s the Brain Teas­er: Ready to stim­u­late those neu­rons in your tem­po­ral lobes?

 

Wish­ing you and yours a healthy and fun summer!

Study finds mixed results of Adderall as cognitive enhancer (seems to boost emotion more than cognition)

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Over the past 15 years there has been grow­ing aware­ness that many col­lege stu­dents with­out an ADHD diag­no­sis use ADHD drugs. On some cam­pus­es, rates of self-report­ed non-med­ical use have exceed­ed 30% of students.

The pri­ma­ry rea­son stu­dents report tak­ing ADHD drugs is to enhance their aca­d­e­m­ic per­for­mance. And, the strong major­i­ty of stu­dents — over 80% in a study I con­duct­ed — believe it is help­ful for this purpose.

Fur­ther­more, stu­dents who report prob­lems with atten­tion are more like­ly to report non-med­ical use than oth­er stu­dents; this sug­gests that some self-med­icate to address their per­ceived atten­tion dif­fi­cul­ties. [Read more…] about Study finds mixed results of Adder­all as cog­ni­tive enhancer (seems to boost emo­tion more than cognition)

The frontal lobes, the little brain down under and “Stayin’ Alive” (3/3)

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[Editor’s note: Con­tin­ued from Explor­ing the human brain and how it responds to stress (1/3) and On World Health Day 2020, let’s dis­cuss the stress response and the Gen­er­al Adap­ta­tion Syn­drome (2/3)]

More on the Cor­tex, the Lim­bic Sys­tem, and Stress:

The cor­tex is made up of four major sec­tions, arranged from the front to the back. These are called the frontal, pari­etal, occip­i­tal, and tem­po­ral lobes. Each of the four lobes is found in both hemi­spheres, and each is respon­si­ble for dif­fer­ent, spe­cial­ized cog­ni­tive func­tions. For exam­ple, the occip­i­tal lobe con­tains the pri­ma­ry visu­al cor­tex, and the tem­po­ral lobe (locat­ed by the tem­ples, and close to the ears) con­tains the pri­ma­ry audi­to­ry cortex.

The frontal lobes are posi­tioned at the front most region of the cere­bral cor­tex and are involved in move­ment, deci­sion mak­ing, prob­lem solv­ing, and plan­ning. There are [Read more…] about The frontal lobes, the lit­tle brain down under and “Stayin’ Alive” (3/3)

Q&A: What does the Facebook acquisition of CTRL-Labs mean for Neurotechnology and Augmented & Virtual Reality?

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While sit­ting at din­ner with an unsus­pect­ing friend, my phone blew up with odd­ly-late mes­sages from fel­low neu­rotech­nol­o­gy com­rades. CTRL-Labs announced their impend­ing acqui­si­tion by Face­book and inte­gra­tion into Face­book Real­i­ty Labs (respon­si­ble for Ocu­lus et al.), for enough mon­ey to buy my guilt-induc­ing­ly-expen­sive New York cof­fee for a mea­ger 550,000 years. Woah—so very many ques­tions. I fig­ured I’d share [Read more…] about Q&A: What does the Face­book acqui­si­tion of CTRL-Labs mean for Neu­rotech­nol­o­gy and Aug­ment­ed & Vir­tu­al Reality?

Forget thinking vs. feeling dichotomy. Think/ feel holistic brain functioning

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brain teasers cognitive stimulationMen­tal Math and the Fine-Tun­ing of Emo­tions (The Dana Foundation)

“You often hear the word “cal­cu­lat­ing” used to describe some­one who always seems to act delib­er­ate­ly, guid­ed by rea­son rather than emo­tion. The idea behind this char­ac­ter­i­za­tion is that human nature strad­dles a deep divide between think­ing and feel­ing, but cur­rent research sug­gests oth­er­wise. Brain-imag­ing stud­ies, in par­tic­u­lar, reveal an over­lap between the sites in the brain that make it pos­si­ble for us to per­form men­tal arith­metic and those that enable us to reg­u­late our emo­tions. In fact, these two dis­sim­i­lar-seem­ing func­tions are housed in the same neigh­bor­hood of the cere­bral cor­tex. But they don’t just reside near each other—they actu­al­ly work togeth­er. “It’s pos­si­ble that train­ing the brain with men­tal math strength­ens the capac­i­ty for emo­tion­al reap­praisal, or per­haps con­tin­u­al­ly run­ning the process of emo­tion­al reap­praisal increas­es the abil­i­ty for men­tal cal­cu­la­tions of oth­er kinds like men­tal arithmetic.”

To learn more: