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digital therapeutics

On mental fitness beliefs, lifestyles and new tools like apps, digital therapeutics, virtual reality, “brain age gaps” and more

May 31, 2022 by SharpBrains Leave a Comment

Wel­come to a new edi­tion of Sharp­Brains’ e‑newsletter, fea­tur­ing time­ly brain & men­tal health news and a fun cou­ple of math brain teasers.

#1. Study on the “ABCs of Men­tal Health” finds that sim­ply believ­ing you can improve men­tal well­be­ing helps actu­al­ly improve it

Beliefs mat­ter.

#2. “Dig­i­tal ther­a­peu­tics” vs. “Men­tal health apps”: A grow­ing debate on stan­dards, reg­u­la­tion and efficacy

Def­i­n­i­tions matter.

#3. How ’sleep­ing on it’ can help the pre­frontal cor­tex reg­u­late emo­tion­al respons­es, mak­ing us feel bet­ter in the morning

Sleep mat­ters.

#4. NICE in the UK issues rec­om­men­da­tion for Sleepio app, the dig­i­tal cog­ni­tive behav­iour­al ther­a­py for insom­nia by Big Health

Inno­va­tion mat­ters: “At a price of £45 per per­son, Sleepio is cost sav­ing com­pared with usu­al treat­ment in pri­ma­ry care. This is based on an analy­sis of pri­ma­ry care resource use data before and after Sleepio was intro­duced in 9 GP prac­tices. Health­care costs were low­er at 1 year, most­ly because of few­er GP appoint­ments and sleep­ing pills prescribed.”

#5. New book pro­vides prac­ti­cal guid­ance for women (and men) to rebal­ance our lifestyles and build Cog­ni­tive Reserve

Lifestyle mat­ters: “The more com­plex our lives are, the more we need sim­ple things that can ground us and help us to be more resilient – to rebal­ance and rebal­ance and rebal­ance again. Build­ing the men­tal mus­cles to find bal­ance when one gets off bal­ance is a crit­i­cal skill thrive and to build cog­ni­tive reserve in our fast-chang­ing times. As our month­ly gath­er­ings showed us over the years, prac­tic­ing rebal­ance in good com­pa­ny not only rein­forces neur­al path­ways and capa­bil­i­ties but also strength­ens the bonds of trust and con­fi­dence that are invalu­able to build a healthy envi­ron­ment to thrive in.”

#6. Study: Auto­mat­ed VR psy­chother­a­py can help reduce anx­i­ety and dis­tress, espe­cial­ly among those with psy­chosis and severe agoraphobia

One of the ben­e­fits of VR is that patients know they are in a sim­u­la­tion, which enables “psy­cho­log­i­cal dis­tance from prob­lem­at­ic reac­tions,” the study authors wrote. “The process of find­ing the best uses and imple­men­ta­tion meth­ods of this immer­sive tech­nol­o­gy at scale in men­tal health is only beginning.”

#7. Fund­ing for dig­i­tal health start-ups, espe­cial­ly in men­tal health, fall sub­stan­tial­ly in Q1’22

“While all tech sec­tors received small­er fund­ing totals than the pre­vi­ous quar­ter, dig­i­tal health plunged much fur­ther than oth­ers did … investor inter­est in men­tal health tech wavered as the mar­ket and pub­lic com­pa­nies like Talk­space and Cere­bral come under scrutiny.”

#8. Deep learn­ing mod­el built on neu­roimag­ing data iden­ti­fies “Brain Age Gaps” as mark­ers of Alzheimer’s dis­ease (AD)

“The main find­ing of our study is that we could indeed find evi­dence that high brain age gap is behav­ing as an accel­er­at­ed brain aging bio­mark­er.” — Dr. David Jones, neu­rol­o­gist at Mayo Clinic

Final­ly, a cou­ple fun brain teasers to help you flex your math/ cog­ni­tive men­tal muscles:

#9. Will you fin­ish your the­sis on time?

#10. Math brain teas­er requir­ing no math — just per­cep­tion and cognition

 

Wish­ing you and yours a healthy and stim­u­lat­ing June!

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Filed Under: Brain/ Mental Health, SharpBrains Monthly eNewsletter, Technology & Innovation Tagged With: apps, biomarker, brain age gaps, brain aging biomarker, Brain Teasers, brain-aging, cognitive, digital health, digital therapeutics, mental health, mental muscles, mental-fitness, sleep, virtual-reality

“Digital therapeutics” vs. “Mental health apps”: A growing debate on standards, regulation and efficacy

May 9, 2022 by SharpBrains Leave a Comment

The effi­ca­cy of Men­tal Health Apps (phar­mafo­rum):

In Jan­u­ary, PLOS Dig­i­tal Health pub­lished a study which claimed that there’s “sparse” data to sup­port the effi­ca­cy of most men­tal health apps.

In their meta-analy­sis of pub­lished stud­ies, the authors found uni­ver­sal defi­cien­cies and con­clud­ed that there’s no con­vinc­ing evi­dence that app-based inter­ven­tions deliv­er mean­ing­ful out­comes. With­out dig­ging fur­ther, one might think the cur­rent case for dig­i­tal ther­a­peu­tics is weak.

I reviewed all 14 meta-analy­ses includ­ed in the study and found the analy­sis to be accu­rate, but incom­plete. [Read more…] about “Dig­i­tal ther­a­peu­tics” vs. “Men­tal health apps”: A grow­ing debate on stan­dards, reg­u­la­tion and efficacy

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Filed Under: Brain/ Mental Health, Technology & Innovation Tagged With: Big Health, digital health, digital therapeutics, Digital Therapeutics Alliance, DTx, FDA, Happify Health, mental health apps, mental illness, meta-analysis, Orexo, PEAR, PLOS Digital Health

News on how the brain changes over time, how to clear foggy brains, how to multitask (or not), and more

April 28, 2022 by SharpBrains Leave a Comment

Wel­come to a new edi­tion of Sharp­Brains’ e‑newsletter, fea­tur­ing time­ly brain & men­tal health news and a fun brain teas­er to test the lim­its of multi-tasking.

#1. Col­lab­o­ra­tive neu­roimag­ing ini­tia­tive Brain­Chart helps chart how brains change across the lifes­pan. Among the many fas­ci­nat­ing findings:

“The vol­ume of grey mat­ter (brain cells) increas­es rapid­ly from mid-ges­ta­tion onwards, peak­ing just before we are six years old. It then begins to decrease slowly.”
“The vol­ume of white mat­ter (brain con­nec­tions) also increased rapid­ly from mid-ges­ta­tion through ear­ly child­hood and peaks just before we are 29 years old.”
“The decline in white mat­ter vol­ume begins to accel­er­ate after 50 years.”

#2. Five ways to clear fog­gy brains and improve cog­ni­tive well-being

“Become more inten­tion­al about con­sum­ing news … news­pa­pers, TV news pro­grams, and many social media sites make their mon­ey by grab­bing your attention—and noth­ing grabs atten­tion bet­ter than neg­a­tive news. But repeat­ed expo­sure to crises wreaks hav­oc with our well-being and can lead to bad deci­sion making.”

#3. As announced in our pre­vi­ous e‑newsletter, the Cen­ter for Brain­Health at UT-Dal­las host­ed a talk titled Nav­i­gat­ing the Brain Health Mar­ket with Álvaro Fer­nán­dez Ibáñez on April 21st. We had over a thou­sand par­tic­i­pants, hun­dreds of com­ments and a superb Q&A at the end — you can enjoy the full ses­sion record­ing HERE, over at YouTube.

#4. Map­ping ‘psy­che­del­ic trips’ in the brain to bet­ter direct their ther­a­peu­tic effects

“Our study shows that it’s pos­si­ble to map the diverse and wild­ly sub­jec­tive psy­che­del­ic expe­ri­ences to spe­cif­ic regions in the brain. These insights may lead to new ways to com­bine exist­ing or yet to be dis­cov­ered com­pounds to pro­duce desired treat­ment effects for a range of psy­chi­atric conditions.”

#5. Altoi­da rais­es fur­ther $14 mil­lion to “democ­ra­tize dig­i­tal cog­ni­tive assess­ment at scale” via aug­ment­ed real­i­ty (AR) and AI

“Through an app down­loaded to a patient’s own smart­phone or tablet, Altoida’s tech first offers up a 10-minute test. A vari­ety of Aug­ment­ed Real­i­ty (AR)-powered exer­cis­es mea­sure 11 areas of the brain that have been linked to Alzheimer’s. The video-game-like activ­i­ties ask users to hide and relo­cate vir­tu­al objects around the room, sim­u­late a fire evac­u­a­tion and search for vir­tu­al items while a sound con­tin­u­ous­ly plays .. The result­ing report high­lights symp­toms of cog­ni­tive decline—such as hand and gait errors, eye track­ing, pupil dila­tion and more—and pro­vides a score of the like­li­hood that they’ll devel­op Alzheimer’s with­in the next year.”

#6. Geisinger and Eisai to test real-world valid­i­ty of AI-pow­ered Pas­sive Dig­i­tal Mark­er (PDM) in detect­ing ear­ly cog­ni­tive impair­ment and dementia

“As an imple­men­ta­tion sci­en­tist, it is always excit­ing to have oth­er sci­en­tists eval­u­ate the repro­ducibil­i­ty of the per­for­mance of our pas­sive dig­i­tal mark­er in very dif­fer­ent pop­u­la­tions,” said Malaz Bous­tani, M.D., Richard M. Fair­banks Pro­fes­sor of Aging Research at Indi­ana Uni­ver­si­ty. “Repro­ducibil­i­ty is the cor­ner­stone of sci­en­tif­ic progress.”

#7. Debate: Will dig­i­tal ther­a­peu­tics gain the required lev­els of aware­ness, adop­tion, reim­burse­ment and ful­fill­ment to become sustainable?

“There’s still a lot of foun­da­tion­al work that needs to be done,” said Maya Desai, direc­tor of life sci­ences for Guide­house. “There’s a lot of behav­ioral change that needs to hap­pen across the stake­hold­ers and their mind­sets to think about dig­i­tal ther­a­peu­tics as a cat­e­go­ry of its own.”

#8. And, yes, here’s the quick brain teas­er to test the lim­its of multitasking

 

Wish­ing you and yours a healthy and stim­u­lat­ing May … Sum­mer is Coming.

 

The Sharp­Brains Team

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Filed Under: Brain/ Mental Health, SharpBrains Monthly eNewsletter, Technology & Innovation Tagged With: Altoida, brain-cells, brain-health-market, BrainChart, cognitive well being, digital therapeutics, Eisai, foggy brains, Geisinger, grey-matter, neuroimaging, psychedelic, psychiatric conditions, white-matter

Debate: Will digital therapeutics gain the required levels of awareness, adoption, reimbursement and fulfillment to become sustainable?

April 21, 2022 by SharpBrains Leave a Comment

Can dig­i­tal ther­a­peu­tics become prof­itable? (MedTech­Dive):

In 2020, the Food and Drug Admin­is­tra­tion cleared Akili Inter­ac­tive’s video game to improve atten­tion in kids with ADHD. It was the first time that a video game for treat­ment was cleared by the agency, and is one exam­ple of a dig­i­tal ther­a­peu­tic, a class of soft­ware-based treat­ments with FDA indications.

Now, as the mar­ket is fur­ther devel­op­ing, these com­pa­nies have built up big ambi­tions. [Read more…] about Debate: Will dig­i­tal ther­a­peu­tics gain the required lev­els of aware­ness, adop­tion, reim­burse­ment and ful­fill­ment to become sustainable?

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Filed Under: Brain/ Mental Health, Technology & Innovation Tagged With: Akili Interactive, digital therapeutic, digital therapeutics, Food and Drug Administration, Pear Therapeutics

From “Eminence-based” to Evidence-based cognitive & mental healthcare: Time for quality and accountability

March 31, 2022 by SharpBrains Leave a Comment

Wel­come to a new edi­tion of Sharp­Brains’ e‑newsletter, fea­tur­ing time­ly brain & men­tal health news, two excel­lent new books and a few fun brain teasers.

#1. From “Emi­nence-based” to Evi­dence-based men­tal health­care: Time to focus on qual­i­ty and accountability

“The real chal­lenge is not find­ing a ther­a­pist, it’s find­ing a ther­a­pist who knows how to pro­vide the treat­ments that work. In the ear­ly 2000s, Myr­na Weiss­man was try­ing to under­stand why so few ther­a­pists use sci­en­tif­i­cal­ly based treat­ments. She found that over 60 per­cent of pro­fes­sion­al schools of psy­chol­o­gy and master’s lev­el social work pro­grams did not include any super­vised train­ing for any sci­en­tif­i­cal­ly based ther­a­py … In con­trast to evi­dence-based care, I call this “emi­nence-based care.” — Dr. Thomas Insel in his excel­lent new book

#2. Anoth­er great new book to cel­e­brate Brain Aware­ness Week 2022

“Spain played a unique role in Cajal’s discoveries—that is, in the pro­gres­sion of neu­ro­science. The coun­try was not a hotbed of sci­en­tif­ic research. Lack­ing men­tors, Cajal near­ly aban­doned his efforts. But work­ing inde­pen­dent­ly may have forged his auton­o­my and freed him from the influ­ence of tra­di­tion­al the­o­ries. He also longed to dis­prove the stereo­types about Spain. “One could admit that Spain pro­duces some genius artist, such as a long-haired poet or ges­tic­u­lat­ing dancer of either sex,” Cajal lat­er wrote, “but the idea that a true man of sci­ence would emerge from there was con­sid­ered absurd.” — Fas­ci­nat­ing insights into the “father of mod­ern neuroscience”

#3. UT-Dal­las Brain­Health presents vir­tu­al talks with Alvaro Fer­nan­dez and San­jay Gup­ta next month (April 21th and 26th; both 8:00 – 9:00 PM EDT/ Mia­mi time)

We believe some of you may be interested 🙂

#4. Cana­di­an study finds causal link between time play­ing videogames at age 12 and ADHD symp­toms at age 13

“After con­trol­ling for sex, socioe­co­nom­ic sta­tus, and ADHD symp­toms at age 12, the week­ly amount video game play report­ed at age 12 pre­dict­ed high­er lev­els of self-report­ed ADHD symp­toms at age 13 … The mag­ni­tude of the effect was not large, but it was sta­tis­ti­cal­ly sig­nif­i­cant. In con­trast, high­er lev­els of ADHD symp­toms at age 12 did not pre­dict an increase in video game play one year later.”

#5. From for­est bathing to urban parks: How nature helps pro­tect our well-being dur­ing a pandemic

“Whether we gar­den, have a view of nature out our win­dow, vis­it near­by parks, or even just watch a nature video, we can help our­selves deal with the stress­es and strains of COVID iso­la­tion by giv­ing our­selves and our kids a dose of “Vit­a­min N.”

#6. A con­ver­sa­tion at the fron­tier of dig­i­tal health inno­va­tion, FDA reg­u­la­tions, and cog­ni­tive health

Good to see rec­og­nized the need for “reim­burse­ment inno­va­tion” for emerg­ing dig­i­tal bio­mark­ers & ther­a­peu­tics — the FDA does have both sticks and car­rots to leverage

#7. New DARPA ini­tia­tive aims to har­ness cog­ni­tive sci­ence, sen­sors and machine learn­ing to detect ear­ly brain signs of depres­sion, anx­i­ety, and sui­ci­dal ideation

“NEAT is a proof-of-con­cept effort attempt­ing to devel­op a new tool for men­tal and behav­ioral health screen­ing that moves us beyond his­tor­i­cal and cur­rent meth­ods of ques­tions and con­scious­ly fil­tered respons­es … If suc­cess­ful, NEAT will not only sig­nif­i­cant­ly aug­ment behav­ioral health screen­ing, but it could also serve as a new way to assess ulti­mate treat­ment effi­ca­cy, since patients will often tell their clin­i­cians what they think the clin­i­cian wants to hear rather than how they are tru­ly feel­ing.” — Greg Witkop, pro­gram man­ag­er in DARPA’s Defense Sci­ences Office

#8. Sep­a­rat­ing brain-healthy wheat from chaff is becom­ing more urgent by the day

Would you trust claims in A or B or neither?

Final­ly, here’s a selec­tion of fun brain teasers that read­ers have enjoyed the most this year so far:

#9. Where’s the baby?

#10. Can you con­nect these pairs of words?

#11. Want to test your stress level?

#12. Which way is the bus head­ing?

 

Wish­ing you and yours a healthy and stim­u­lat­ing April … and let’s get some Vit­a­min N (and D) this weekend!

The Sharp­Brains Team

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Filed Under: Brain/ Mental Health, Education & Lifelong Learning, SharpBrains Monthly eNewsletter, Technology & Innovation Tagged With: adhd, ADHD-symptoms, alvaro-fernandez, behavioral health screening, Brain Teasers, BrainHealth, Cajal, cognitive-abilities, DARPA, digital biomarkers, digital therapeutics, FDA, fun brain teasers, mental health screening, mental healthcare, NEAT, neuroscience, playing videogames, Sanjay Gupta, Spain, stimulating brain teasers, therapist, UT-Dallas

Separating brain-healthy wheat from chaff is becoming more urgent by the day

March 21, 2022 by SharpBrains Leave a Comment

A) New video game com­pa­ny aims to devel­op ther­a­peu­tic games (The Verge):

Video game-based tools can help with con­di­tions like depres­sion and ADHD, research shows. Deep­Well Dig­i­tal Ther­a­peu­tics plans to build on those stud­ies. “There was an amaz­ing amount of sci­ence that had already been done,” Dou­glas says. “We start­ed to rec­og­nize exact­ly how ther­a­peu­tic these games already were.” [Read more…] about Sep­a­rat­ing brain-healthy wheat from chaff is becom­ing more urgent by the day

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Filed Under: Technology & Innovation Tagged With: adhd, Bayer, DeepWell, depression, digital therapeutics, Woebot Health

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