cognitive decline

On cognitive training, muscle mass, neurostimulation, brain teasers, apps, and more

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Wel­come to a new edi­tion of Sharp­Brains’ e‑newsletter, fea­tur­ing time­ly brain & inno­va­tion news and a few fun teasers to test your work­ing memory.

#1. Study: Build­ing mus­cle mass helps delay cog­ni­tive decline beyond the val­ue of exer­cise itself

“Teas­ing out exact­ly how mus­cle helps the brain remains a chal­lenge. There are plen­ty of indi­rect links … But Dr. Chevalier’s results sug­gest there may be more direct mech­a­nisms too. One pos­si­bil­i­ty is the role of myokines, a set of hor­mone-like mol­e­cules pro­duced by mus­cle cells that can trav­el to the brain and influ­ence mood, learn­ing and oth­er cog­ni­tive func­tions. Greater mus­cle mass may also help keep blood glu­cose lev­els in check, pro­tect­ing the brain from damage.”

#2. Clin­i­cians and aca­d­e­mics should engage users when review­ing apps, study finds

“More than half of the app rat­ings showed dis­agree­ment between par­tic­i­pants and pro­fes­sion­als … Par­tic­i­pants par­tic­u­lar­ly val­ued cer­tain aspects of men­tal health apps, which appear to be over­looked by pro­fes­sion­al review­ers. These includ­ed func­tions such as the abil­i­ty to track and mea­sure men­tal health and pro­vid­ing gen­er­al men­tal health edu­ca­tion. The cost of apps was among the most impor­tant fac­tors for participants.”

#3. Com­bined tDCS neu­rostim­u­la­tion and cog­ni­tive train­ing found to improve work­ing mem­o­ry among old­er adults–especially those with low­er start­ing capacity

“… indi­vid­ual char­ac­ter­is­tics influ­enced the out­come of com­bined cog­ni­tive train­ing and tDCS reg­i­mens, with the inter­ven­tion selec­tive­ly ben­e­fit­ing old-old adults with low­er work­ing mem­o­ry capac­i­ty. Future work should con­sid­er devel­op­ing indi­vid­u­al­ized treat­ments by con­sid­er­ing indi­vid­ual dif­fer­ences in cog­ni­tive profiles.”

#4. Head­space Health’s Leslie Witt on the future of men­tal health

“I fun­da­men­tal­ly believe in the pow­er of mind­ful­ness and med­i­ta­tion tools, but they can’t serve all men­tal health needs. And par­tic­u­lar­ly when someone’s in a state of acute anx­i­ety, acute depres­sion, they need access to pro­fes­sion­al, human services…We are build­ing out what I often call the mid­dle piece, the bridge that exists between the self-serve con­tent in the Head­space app and the text-based coach­ing, telether­a­py and telepsy­chi­a­try of the Gin­ger service.”

#5. Study: Prac­tic­ing grat­i­tude helps low­er phys­i­o­log­i­cal stress lev­els of the “express­er” AND the “receiv­er”

“The impli­ca­tion here is that you should let your grat­i­tude out when you feel it … That’s not to say that you should go around and make up grat­i­tude expres­sions for no rea­son. But, when you gen­uine­ly feel grat­i­tude, you should express it.” — Christo­pher Oveis, Direc­tor of the Empa­thy & Emo­tion Lab at UCSD

#6. Tak­ing your brain vitals: Sto­ries from a tech­no-opti­mist invent­ing the future of human performance

“My vision for DANA has always been that every time you go to the doc­tor, in addi­tion to tak­ing your height, weight, blood pres­sure, and tem­per­a­ture, they will take your DANA brain vital. When mea­sur­ing your brain health becomes sec­ond nature—as com­mon as check­ing your blood pressure—it will empow­er every­one, no mat­ter their age, to spot changes soon­er and take action.” — Cori Lath­an, CEO of Anthro­Tron­ix, in her great new book.

#7. UK agen­cies to review and update reg­u­la­tion of dig­i­tal men­tal health tools

Time­ly and impor­tant work to be done by the Med­i­cines and Health­care prod­ucts Reg­u­la­to­ry Agency (MHRA) and the Nation­al Insti­tute for Health and Care Excel­lence (NICE).

#8. Last but not least, let us share a few quick brain teasers to exer­cise your work­ing mem­o­ry … enjoy!

 

Wish­ing you and yours a healthy and warm month of November

Study: Building muscle mass helps delay cognitive decline beyond the value of exercise itself

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A new rea­son to build mus­cle: brain health (The Globe and Mail):

… a recent study from researchers at McGill Uni­ver­si­ty, pub­lished in the jour­nal JAMA Net­work Open, offers a new rea­son for con­tin­u­ing to work on build­ing mus­cle: It’s good for your brain, not just your biceps. Greater mus­cle mass, the results sug­gest, helps ward off cog­ni­tive decline in old­er adults beyond what you’d expect based on their exer­cise lev­els alone. [Read more…] about Study: Build­ing mus­cle mass helps delay cog­ni­tive decline beyond the val­ue of exer­cise itself

Dual decline in gait speed and memory function seen as most predictive of future dementia

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Walk­ing Speed Helps Pre­dict Future Demen­tia (Med­Page Today):

Dual decline in gait speed and cog­ni­tion car­ried a high­er risk of demen­tia than either gait-only decline or cog­ni­tive-only decline, report­ed Taya Col­ly­er, PhD, of Monash Uni­ver­si­ty in Vic­to­ria, Aus­tralia, and co-authors, in JAMA Net­work Open…

[Read more…] about Dual decline in gait speed and mem­o­ry func­tion seen as most pre­dic­tive of future dementia

Altoida raises further $14 million to “democratize digital cognitive assessment at scale” via augmented reality (AR) and AI

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Altoi­da snags Mer­ck KGaA-led $14M fund­ing round for Alzheimer’s diag­nos­tic app (Fierce Biotech):

The $14 mil­lion top-up came from a mix of old and new investors, co-led by White­cap Ven­ture Part­ners and Mer­ck KGaA’s cor­po­rate VC arm, M Ven­tures, which also led the ini­tial tranche of series A financ­ing … The new­ly upsized fund­ing will help Altoi­da add to its work­force, pay for intel­lec­tu­al prop­er­ty and reg­u­la­to­ry fil­ings and con­tin­ue devel­op­ing its tech plat­form to assess neu­ro­log­i­cal func­tion. [Read more…] about Altoi­da rais­es fur­ther $14 mil­lion to “democ­ra­tize dig­i­tal cog­ni­tive assess­ment at scale” via aug­ment­ed real­i­ty (AR) and AI

Study: Education and lifestyle helped over a million older Americans avoid serious cognitive problems in 2017

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Study: More U.S. seniors, espe­cial­ly women, retain­ing health brains (UPI):

The per­cent­age of old­er Amer­i­cans report­ing seri­ous prob­lems with mem­o­ry and think­ing has declined in recent years — and high­er edu­ca­tion lev­els may be part of the rea­son, a new study finds. [Read more…] about Study: Edu­ca­tion and lifestyle helped over a mil­lion old­er Amer­i­cans avoid seri­ous cog­ni­tive prob­lems in 2017

Update: Why MDMA-assisted psychotherapy may become an FDA-approved treatment for PTSD within 2 years

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Wel­come to a new edi­tion of Sharp­Brains’ e‑newsletter, shar­ing impor­tant brain/ men­tal health news plus a few fun opti­cal illu­sions to tease and appre­ci­ate our unique human minds.

#1. Why MDMA-assist­ed psy­chother­a­py may become an FDA-approved treat­ment for PTSD with­in 2 years

“We are a phar­ma­cist and physi­cian team who inves­ti­gate the ben­e­fits and harms asso­ci­at­ed with sub­stances of abuse like bath salts, phenibut, cannabis and syn­thet­ic mar­i­jua­na. Through this work we have become intrigued about the ther­a­peu­tic poten­tial for some psy­che­del­ic drugs in the treat­ment of myr­i­ad psy­chi­atric dis­or­ders, from PTSD to major depres­sion … It is impor­tant to state that using ecsta­sy or mol­ly prod­ucts from the street would not help PTSD symp­toms because the MDMA needs be used along with care­ful­ly craft­ed psy­chother­a­py in a safe, con­trolled envi­ron­ment. Ecsta­sy or mol­ly prod­ucts pur­chased illic­it­ly nev­er spec­i­fy the exact amount of MDMA they con­tain, so it is impos­si­ble to dose it prop­er­ly for PTSD. Tak­ing too much MDMA or exer­cis­ing while tak­ing MDMA can cause heart attacks, strokes, seizures and arrhyth­mias and can dam­age mus­cles and kidneys.”

#2. Ten insights on human well-being and poten­tial from two giants we sad­ly lost in 2021: Mihaly Csik­szent­mi­ha­lyi and Ed Diener

“Your well-being can change: One com­mon notion with­in psy­chol­o­gy before the pos­i­tive psy­chol­o­gy move­ment was that indi­vid­u­als had a set hap­pi­ness point, and that this point did not change dras­ti­cal­ly. So why both­er try­ing to improve it, right? Diener helped to change that nar­ra­tive by find­ing that cer­tain sig­nif­i­cant events did in fact change well-being per­ma­nent­ly. This sug­gests that inter­ven­tions can have a last­ing impact, and has paved the way for pos­i­tive psy­chol­o­gists to focus on apply­ing their research to improve the human condition.”

#3. Com­plex occu­pa­tions help pro­tect our brains from aging-relat­ed cog­ni­tive decline

“ … dif­fer­ences in cog­ni­tive decline have been often observed in asso­ci­a­tion with edu­ca­tion or oth­er relat­ed to qual­i­ty of life. From our analy­sis it emerges that the type of work activ­i­ty also con­tributes to the dif­fer­ences in nor­mal and patho­log­i­cal cog­ni­tive aging”

#4. On brain fold­ing and fit­ting 86 bil­lion neu­rons inside our 1400 cc crania

“Under­stand­ing the mech­a­nisms behind brain fold­ing and con­nec­tiv­i­ty will pro­vide researchers with the knowl­edge foun­da­tion to uncov­er their role in devel­op­men­tal brain dis­or­ders. In the long term, clar­i­fy­ing the con­nec­tion between brain struc­ture and func­tion may lead to ear­ly diag­nos­tic tools for brain dis­eases … researchers like us have our work cut out for us as we con­tin­ue try­ing to deci­pher the mys­tery of the most com­plex known struc­ture in the universe.”

#5. Pear Ther­a­peu­tics rais­es $175M and goes pub­lic via SPAC deal rais­ing the pro­file of pre­scrip­tion dig­i­tal therapeutics

The Times They Are a‑Changin’ …

#6. Sol­era Health includes Gin­ger and eMind­ful to expand dig­i­tal men­tal health­care platform

“eMind­ful and Gin­ger join Solera’s curat­ed Men­tal and Behav­ioral Health Net­work, which already includ­ed lead­ing med­i­ta­tion, mind­ful­ness, and men­tal train­ing app, Head­space. Sol­era con­tin­ues to expand its suite of whole-per­son health solu­tions to sup­port health jour­neys across acu­ity lev­els and clin­i­cal personas.”

And here are two old­er posts which have remained among our Most Read in 2021:

#7. Eight Tips To Remem­ber What You Read

“Despite tele­vi­sion, cell phones, and Twit­ter, tra­di­tion­al read­ing is still an impor­tant skill. Whether it is school text­books, mag­a­zines, or reg­u­lar books, peo­ple still read, though not as much as they used to. One rea­son that many peo­ple don’t read much is that they don’t read well. For them, it is slow, hard work and they don’t remem­ber as much as they should … I sum­ma­rize below what I think it takes to read with good speed and comprehension.”

#8. Test your Brain with these 10 Opti­cal Illusions

One way to learn more about our visu­al sys­tem is to look at how we can trick it … give these ten illu­sions a try!

Wish­ing you and yours a Healthy & Pros­per­ous 2022,

 

The Sharp­Brains Team