Brain Teasers

On cognitive-physical training, brain biomarkers, dementia, ketamine, brain teasers, riddles and more

by Leave a Comment

Wel­come to the last 2022 edi­tion of Sharp­Brains e‑newsletter, fea­tur­ing a few select­ed brain health news and fun teasers to chal­lenge your brain and help us all think out­side the box.

#1. “Every­one agrees that Google Glass failed when it came to mar­ket, but to me, it’s a sym­bol of hope … It inspired peo­ple to think beyond tra­di­tion­al ways of mov­ing about our envi­ron­ment. Instead of look­ing down at a device, we could look out at the world and have an over­lay of dig­i­tal infor­ma­tion. It was one of the first steps in physical–digital con­ver­gence that we are see­ing today through­out many indus­tries. And as some­one who has cre­at­ed many inven­tions that nev­er left the lab or were too ear­ly for the mar­ket, I love the fact that Glass came out at all!” — wise words by neu­rotech entre­pre­neur Dr. Cori Lath­an in her new (and excel­lent) book. See Tech­nol­o­gy as a bridge in time: Shap­ing the future of brain health via today’s innovations–including those that “fail”

#2. “Some peo­ple want to do cog­ni­tive train­ing while mov­ing rather than sit­ting down, and that real­ly spoke to me as a pos­si­bil­i­ty for real ben­e­fits giv­en anec­do­tal sto­ries about games like ‘Dance Dance Rev­o­lu­tion.’” — Joaquin A. Anguera, asso­ciate pro­fes­sor at UCSF and direc­tor of Neuroscape‘s Clin­i­cal Divi­sion. See Study: A com­bined cog­ni­tive-phys­i­cal train­ing approach may enhance both mind and body as we age

#3. “Giv­en that ketamine’s rapid action and unex­pect­ed dis­so­cia­tive effects make it a poten­tial­ly worth­while option for treat­ing men­tal health prob­lems, we are on a mis­sion to unpack this mys­tery, at the cross­roads between phar­ma­col­o­gy and neu­ro­science.” See Study iden­ti­fies cog­ni­tive ben­e­fits of ket­a­mine in patients with treat­ment-resis­tant depression

#4. “The grat­i­tude writ­ing group main­tained grat­i­tude lev­els and decreased stress and neg­a­tive affect at one-month post-inter­ven­tion” — that main­te­nance aspect is espe­cial­ly inter­est­ing. See Thanks­giv­ing works: Grat­i­tude jour­nal­ing seen to low­er stress and neg­a­tive cog­ni­tive processes

#5. Impres­sive new funding–especially giv­en mar­ket conditions–with a goal to iden­ti­fy “brain bio­mark­ers by ana­lyz­ing EEG activ­i­ty, behav­ioral task per­for­mance, wear­able data, genet­ics, and oth­er fac­tors to match each patient with the right Alto drug.” See Pre­ci­sion psy­chi­a­try pio­neer Alto Neu­ro­science rais­es $35M to advance dig­i­tal bio­mark­er-to-treat­ment platform

#6. Some bad news. See The FDA ends pre­cer­ti­fi­ca­tion (Pre-Cert) pilot pro­gram, say­ing new author­i­ty required to reg­u­late soft­ware as a med­ical device (SaMD)

#7. And some great news: “(Péter Hudomi­et, study’s lead author) said it’s also pos­si­ble that, giv­en numer­ous stud­ies being released on steps to take to avoid demen­tia, some of the decline may be attrib­uted to peo­ple heed­ing such advice.” See Study finds sharp decrease (near­ly one-third) in the preva­lence of demen­tia among those 65+ in the Unit­ed States

#8. Final­ly, here are a few brain teasers to stim­u­late those neu­rons in your tem­po­ral lobes and to help us all think out­side the box.

 

Have a healthy and won­der­ful 2023!

 

On cognitive training, muscle mass, neurostimulation, brain teasers, apps, and more

by Leave a Comment

Wel­come to a new edi­tion of Sharp­Brains’ e‑newsletter, fea­tur­ing time­ly brain & inno­va­tion news and a few fun teasers to test your work­ing memory.

#1. Study: Build­ing mus­cle mass helps delay cog­ni­tive decline beyond the val­ue of exer­cise itself

“Teas­ing out exact­ly how mus­cle helps the brain remains a chal­lenge. There are plen­ty of indi­rect links … But Dr. Chevalier’s results sug­gest there may be more direct mech­a­nisms too. One pos­si­bil­i­ty is the role of myokines, a set of hor­mone-like mol­e­cules pro­duced by mus­cle cells that can trav­el to the brain and influ­ence mood, learn­ing and oth­er cog­ni­tive func­tions. Greater mus­cle mass may also help keep blood glu­cose lev­els in check, pro­tect­ing the brain from damage.”

#2. Clin­i­cians and aca­d­e­mics should engage users when review­ing apps, study finds

“More than half of the app rat­ings showed dis­agree­ment between par­tic­i­pants and pro­fes­sion­als … Par­tic­i­pants par­tic­u­lar­ly val­ued cer­tain aspects of men­tal health apps, which appear to be over­looked by pro­fes­sion­al review­ers. These includ­ed func­tions such as the abil­i­ty to track and mea­sure men­tal health and pro­vid­ing gen­er­al men­tal health edu­ca­tion. The cost of apps was among the most impor­tant fac­tors for participants.”

#3. Com­bined tDCS neu­rostim­u­la­tion and cog­ni­tive train­ing found to improve work­ing mem­o­ry among old­er adults–especially those with low­er start­ing capacity

“… indi­vid­ual char­ac­ter­is­tics influ­enced the out­come of com­bined cog­ni­tive train­ing and tDCS reg­i­mens, with the inter­ven­tion selec­tive­ly ben­e­fit­ing old-old adults with low­er work­ing mem­o­ry capac­i­ty. Future work should con­sid­er devel­op­ing indi­vid­u­al­ized treat­ments by con­sid­er­ing indi­vid­ual dif­fer­ences in cog­ni­tive profiles.”

#4. Head­space Health’s Leslie Witt on the future of men­tal health

“I fun­da­men­tal­ly believe in the pow­er of mind­ful­ness and med­i­ta­tion tools, but they can’t serve all men­tal health needs. And par­tic­u­lar­ly when someone’s in a state of acute anx­i­ety, acute depres­sion, they need access to pro­fes­sion­al, human services…We are build­ing out what I often call the mid­dle piece, the bridge that exists between the self-serve con­tent in the Head­space app and the text-based coach­ing, telether­a­py and telepsy­chi­a­try of the Gin­ger service.”

#5. Study: Prac­tic­ing grat­i­tude helps low­er phys­i­o­log­i­cal stress lev­els of the “express­er” AND the “receiv­er”

“The impli­ca­tion here is that you should let your grat­i­tude out when you feel it … That’s not to say that you should go around and make up grat­i­tude expres­sions for no rea­son. But, when you gen­uine­ly feel grat­i­tude, you should express it.” — Christo­pher Oveis, Direc­tor of the Empa­thy & Emo­tion Lab at UCSD

#6. Tak­ing your brain vitals: Sto­ries from a tech­no-opti­mist invent­ing the future of human performance

“My vision for DANA has always been that every time you go to the doc­tor, in addi­tion to tak­ing your height, weight, blood pres­sure, and tem­per­a­ture, they will take your DANA brain vital. When mea­sur­ing your brain health becomes sec­ond nature—as com­mon as check­ing your blood pressure—it will empow­er every­one, no mat­ter their age, to spot changes soon­er and take action.” — Cori Lath­an, CEO of Anthro­Tron­ix, in her great new book.

#7. UK agen­cies to review and update reg­u­la­tion of dig­i­tal men­tal health tools

Time­ly and impor­tant work to be done by the Med­i­cines and Health­care prod­ucts Reg­u­la­to­ry Agency (MHRA) and the Nation­al Insti­tute for Health and Care Excel­lence (NICE).

#8. Last but not least, let us share a few quick brain teasers to exer­cise your work­ing mem­o­ry … enjoy!

 

Wish­ing you and yours a healthy and warm month of November

On mental fitness beliefs, lifestyles and new tools like apps, digital therapeutics, virtual reality, “brain age gaps” and more

by

Wel­come to a new edi­tion of Sharp­Brains’ e‑newsletter, fea­tur­ing time­ly brain & men­tal health news and a fun cou­ple of math brain teasers.

#1. Study on the “ABCs of Men­tal Health” finds that sim­ply believ­ing you can improve men­tal well­be­ing helps actu­al­ly improve it

Beliefs mat­ter.

#2. “Dig­i­tal ther­a­peu­tics” vs. “Men­tal health apps”: A grow­ing debate on stan­dards, reg­u­la­tion and efficacy

Def­i­n­i­tions matter.

#3. How ’sleep­ing on it’ can help the pre­frontal cor­tex reg­u­late emo­tion­al respons­es, mak­ing us feel bet­ter in the morning

Sleep mat­ters.

#4. NICE in the UK issues rec­om­men­da­tion for Sleepio app, the dig­i­tal cog­ni­tive behav­iour­al ther­a­py for insom­nia by Big Health

Inno­va­tion mat­ters: “At a price of £45 per per­son, Sleepio is cost sav­ing com­pared with usu­al treat­ment in pri­ma­ry care. This is based on an analy­sis of pri­ma­ry care resource use data before and after Sleepio was intro­duced in 9 GP prac­tices. Health­care costs were low­er at 1 year, most­ly because of few­er GP appoint­ments and sleep­ing pills prescribed.”

#5. New book pro­vides prac­ti­cal guid­ance for women (and men) to rebal­ance our lifestyles and build Cog­ni­tive Reserve

Lifestyle mat­ters: “The more com­plex our lives are, the more we need sim­ple things that can ground us and help us to be more resilient – to rebal­ance and rebal­ance and rebal­ance again. Build­ing the men­tal mus­cles to find bal­ance when one gets off bal­ance is a crit­i­cal skill thrive and to build cog­ni­tive reserve in our fast-chang­ing times. As our month­ly gath­er­ings showed us over the years, prac­tic­ing rebal­ance in good com­pa­ny not only rein­forces neur­al path­ways and capa­bil­i­ties but also strength­ens the bonds of trust and con­fi­dence that are invalu­able to build a healthy envi­ron­ment to thrive in.”

#6. Study: Auto­mat­ed VR psy­chother­a­py can help reduce anx­i­ety and dis­tress, espe­cial­ly among those with psy­chosis and severe agoraphobia

One of the ben­e­fits of VR is that patients know they are in a sim­u­la­tion, which enables “psy­cho­log­i­cal dis­tance from prob­lem­at­ic reac­tions,” the study authors wrote. “The process of find­ing the best uses and imple­men­ta­tion meth­ods of this immer­sive tech­nol­o­gy at scale in men­tal health is only beginning.”

#7. Fund­ing for dig­i­tal health start-ups, espe­cial­ly in men­tal health, fall sub­stan­tial­ly in Q1’22

“While all tech sec­tors received small­er fund­ing totals than the pre­vi­ous quar­ter, dig­i­tal health plunged much fur­ther than oth­ers did … investor inter­est in men­tal health tech wavered as the mar­ket and pub­lic com­pa­nies like Talk­space and Cere­bral come under scrutiny.”

#8. Deep learn­ing mod­el built on neu­roimag­ing data iden­ti­fies “Brain Age Gaps” as mark­ers of Alzheimer’s dis­ease (AD)

“The main find­ing of our study is that we could indeed find evi­dence that high brain age gap is behav­ing as an accel­er­at­ed brain aging bio­mark­er.” — Dr. David Jones, neu­rol­o­gist at Mayo Clinic

Final­ly, a cou­ple fun brain teasers to help you flex your math/ cog­ni­tive men­tal muscles:

#9. Will you fin­ish your the­sis on time?

#10. Math brain teas­er requir­ing no math — just per­cep­tion and cognition

 

Wish­ing you and yours a healthy and stim­u­lat­ing June!

From “Eminence-based” to Evidence-based cognitive & mental healthcare: Time for quality and accountability

by

Wel­come to a new edi­tion of Sharp­Brains’ e‑newsletter, fea­tur­ing time­ly brain & men­tal health news, two excel­lent new books and a few fun brain teasers.

#1. From “Emi­nence-based” to Evi­dence-based men­tal health­care: Time to focus on qual­i­ty and accountability

“The real chal­lenge is not find­ing a ther­a­pist, it’s find­ing a ther­a­pist who knows how to pro­vide the treat­ments that work. In the ear­ly 2000s, Myr­na Weiss­man was try­ing to under­stand why so few ther­a­pists use sci­en­tif­i­cal­ly based treat­ments. She found that over 60 per­cent of pro­fes­sion­al schools of psy­chol­o­gy and master’s lev­el social work pro­grams did not include any super­vised train­ing for any sci­en­tif­i­cal­ly based ther­a­py … In con­trast to evi­dence-based care, I call this “emi­nence-based care.” — Dr. Thomas Insel in his excel­lent new book

#2. Anoth­er great new book to cel­e­brate Brain Aware­ness Week 2022

“Spain played a unique role in Cajal’s discoveries—that is, in the pro­gres­sion of neu­ro­science. The coun­try was not a hotbed of sci­en­tif­ic research. Lack­ing men­tors, Cajal near­ly aban­doned his efforts. But work­ing inde­pen­dent­ly may have forged his auton­o­my and freed him from the influ­ence of tra­di­tion­al the­o­ries. He also longed to dis­prove the stereo­types about Spain. “One could admit that Spain pro­duces some genius artist, such as a long-haired poet or ges­tic­u­lat­ing dancer of either sex,” Cajal lat­er wrote, “but the idea that a true man of sci­ence would emerge from there was con­sid­ered absurd.” — Fas­ci­nat­ing insights into the “father of mod­ern neuroscience”

#3. UT-Dal­las Brain­Health presents vir­tu­al talks with Alvaro Fer­nan­dez and San­jay Gup­ta next month (April 21th and 26th; both 8:00 – 9:00 PM EDT/ Mia­mi time)

We believe some of you may be interested 🙂

#4. Cana­di­an study finds causal link between time play­ing videogames at age 12 and ADHD symp­toms at age 13

“After con­trol­ling for sex, socioe­co­nom­ic sta­tus, and ADHD symp­toms at age 12, the week­ly amount video game play report­ed at age 12 pre­dict­ed high­er lev­els of self-report­ed ADHD symp­toms at age 13 … The mag­ni­tude of the effect was not large, but it was sta­tis­ti­cal­ly sig­nif­i­cant. In con­trast, high­er lev­els of ADHD symp­toms at age 12 did not pre­dict an increase in video game play one year later.”

#5. From for­est bathing to urban parks: How nature helps pro­tect our well-being dur­ing a pandemic

“Whether we gar­den, have a view of nature out our win­dow, vis­it near­by parks, or even just watch a nature video, we can help our­selves deal with the stress­es and strains of COVID iso­la­tion by giv­ing our­selves and our kids a dose of “Vit­a­min N.”

#6. A con­ver­sa­tion at the fron­tier of dig­i­tal health inno­va­tion, FDA reg­u­la­tions, and cog­ni­tive health

Good to see rec­og­nized the need for “reim­burse­ment inno­va­tion” for emerg­ing dig­i­tal bio­mark­ers & ther­a­peu­tics — the FDA does have both sticks and car­rots to leverage

#7. New DARPA ini­tia­tive aims to har­ness cog­ni­tive sci­ence, sen­sors and machine learn­ing to detect ear­ly brain signs of depres­sion, anx­i­ety, and sui­ci­dal ideation

“NEAT is a proof-of-con­cept effort attempt­ing to devel­op a new tool for men­tal and behav­ioral health screen­ing that moves us beyond his­tor­i­cal and cur­rent meth­ods of ques­tions and con­scious­ly fil­tered respons­es … If suc­cess­ful, NEAT will not only sig­nif­i­cant­ly aug­ment behav­ioral health screen­ing, but it could also serve as a new way to assess ulti­mate treat­ment effi­ca­cy, since patients will often tell their clin­i­cians what they think the clin­i­cian wants to hear rather than how they are tru­ly feel­ing.” — Greg Witkop, pro­gram man­ag­er in DARPA’s Defense Sci­ences Office

#8. Sep­a­rat­ing brain-healthy wheat from chaff is becom­ing more urgent by the day

Would you trust claims in A or B or neither?

Final­ly, here’s a selec­tion of fun brain teasers that read­ers have enjoyed the most this year so far:

#9. Where’s the baby?

#10. Can you con­nect these pairs of words?

#11. Want to test your stress level?

#12. Which way is the bus head­ing?

 

Wish­ing you and yours a healthy and stim­u­lat­ing April … and let’s get some Vit­a­min N (and D) this weekend!

The Sharp­Brains Team

A great new book and five fun brain teasers to celebrate Brain Awareness Week 2022

by

Neu­rons of the spinal cord and con­nec­tions as seen in a pho­tomi­cro­graph using a stain­ing method pio­neered by San­ti­a­go Ramón y Cajal. PHOTO: ALAMY

Brain Aware­ness Week 2022 just started!

Let’s cel­e­brate our human brains by learn­ing more about neu­ro­science pio­neer San­ti­a­go Ramón y Cajal via a great new book about his life and by chal­leng­ing our minds with a few fun brain teasers and illu­sions below ?

First, some fas­ci­nat­ing insights into the “father of mod­ern neu­ro­science” from a superb book review:

It was dur­ing a trip to Madrid for his exams that Cajal vis­it­ed a lab where he learned how to look at cells under a micro­scope. He fell in love. He had dreamed of explor­ing new worlds, Mr. Ehrlich tells us, “and he thought of micro­scop­ic anatomists as ‘Colum­bus­es.’ ” His ship was launched. Cajal spent hours alone, star­ing at cells and sketching.

Spain played a unique role in Cajal’s discoveries—that is, in the pro­gres­sion of neu­ro­science. The coun­try was not a hotbed of sci­en­tif­ic research. Lack­ing men­tors, Cajal near­ly aban­doned his efforts. But work­ing inde­pen­dent­ly may have forged his auton­o­my and freed him from the influ­ence of tra­di­tion­al the­o­ries. He also longed to dis­prove the stereo­types about Spain. “One could admit that Spain pro­duces some genius artist, such as a long-haired poet or ges­tic­u­lat­ing dancer of either sex,” Cajal lat­er wrote, “but the idea that a true man of sci­ence would emerge from there was con­sid­ered absurd.”

And here’s a selec­tion of five stim­u­lat­ing brain teasers that read­ers enjoyed the most so far in 2022:

  1. Where’s the baby?
  2. Please com­plete these proverbs to exer­cise your brain in famil­iar and nov­el ways
  3. Want to test your stress level?
  4. Which way is the bus head­ing?
  5. Can you con­nect these pairs of words?

About Brain Awareness Week:

Every March, Brain Aware­ness Week (BAW) unites the efforts of part­ner orga­ni­za­tions world­wide in a cel­e­bra­tion of the brain for peo­ple of all ages. Activ­i­ties are lim­it­ed only by the orga­niz­ers’ imag­i­na­tions and include open days at neu­ro­science labs; exhi­bi­tions about the brain; lec­tures on brain-relat­ed top­ics; social media cam­paigns; dis­plays at libraries and com­mu­ni­ty cen­ters; class­room work­shops; and more. This year BAW takes place March 14–20th, 2022.

Let’s Thank our unique Human Brains and Minds with a few family-friendly riddles

by

 

 

Q: What is a sure way of sus­tain­ing a friend­ly and socia­ble feel­ing towards the whole world?
A: Con­sort only with strangers.

Q: What beats regret­ting what you said?
A: Trea­sur­ing what you DIDN’T say.

Q: What does, “you must come and vis­it us some­time!” actu­al­ly mean?
A: Noth­ing at all. How­ev­er, if you take it seri­ous­ly, be ready for the what-are-you-doing-here welcome!

– Kei­th Per­reur-Lloyd is an Anglo-French com­pos­er and musi­cian cur­rent­ly liv­ing in Spain. You can learn more about his clas­si­cal com­po­si­tions here.

More fun ways to challenge our brains and minds: