brain-reserve

Study with 330 centenarians finds that cognitive decline is not inevitable

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Hen­drik­je van Andel Schip­per (1890–2005)

Age-Relat­ed Cog­ni­tive Decline May Not Be Inevitable (Web­MD):

It is often assumed that a decrease in mem­o­ry and brain func­tion are inevitable parts of aging, but a new study of cen­te­nar­i­ans sug­gests otherwise.

Inves­ti­ga­tors found that despite the pres­ence of neu­ro­log­i­cal issues gen­er­al­ly asso­ci­at­ed with Alzheimer’s dis­ease (AD), many cen­te­nar­i­ans main­tained high lev­els of cog­ni­tive performance.

(Henne Hol­stege, PhD, assis­tant pro­fes­sor at Ams­ter­dam Uni­ver­si­ty Med­ical Cen­ter) said her inter­est in research­ing aging and cog­ni­tive health was inspired by the “fas­ci­nat­ing” sto­ry of Hen­drik­je van Andel Schip­per, who died at age 115 in 2005 “com­plete­ly cog­ni­tive­ly healthy.” Her moth­er, who died at age 100, was also cog­ni­tive­ly intact at the end of her life. [Read more…] about Study with 330 cen­te­nar­i­ans finds that cog­ni­tive decline is not inevitable

Update: Understanding Brain Health via Cosmological Health, and vice versa

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LEFT: SECTION OF CEREBELLUM, WITH MAGNIFICATION FACTOR 40X, OBTAINED WITH ELECTRON MICROSCOPY (DR. E. ZUNARELLI, UNIVERSITY HOSPITAL OF MODENA); RIGHT: SECTION OF A COSMOLOGICAL SIMULATION, WITH AN EXTENSION OF 300 MILLION LIGHT-YEARS ON EACH SIDE (VAZZA ET AL. 2019 A&A). CREDIT: UNIVERSITY OF BOLOGNA

Wel­come to a new edi­tion of Sharp­Brains’ e‑newsletter, fea­tur­ing fas­ci­nat­ing find­ings, books and resources for life­long brain health.

#1. “The human brain (sec­tion; left image above) func­tions thanks to its wide neu­ronal net­work that is deemed to con­tain approx­i­mate­ly 69 bil­lion neu­rons. On the oth­er hand, the observ­able uni­verse (sec­tion sim­u­la­tion; right image) can count upon a cos­mic web of at least 100 bil­lion galax­ies. With­in both sys­tems, only 30% of their mass­es are com­posed of galax­ies and neu­rons. With­in both sys­tems, galax­ies and neu­rons arrange them­selves in long fil­a­ments or nodes between the fil­a­ments. Final­ly, with­in both sys­tems, 70% of the dis­tri­b­u­tion of mass or ener­gy is com­posed of com­po­nents play­ing an appar­ent­ly pas­sive role: water in the brain and dark ener­gy in the observ­able Uni­verse.” Under­stand­ing Brain Health via Cos­mo­log­i­cal Health, and vice versa

#2. One very smart and gen­er­ous brain to bright­en your day: Indi­an teacher Ran­jitsinh Disale wins annu­al $1M Glob­al Teacher Prize; shares half with 9 finalists

#3. “Of all the qual­i­ties par­ents can cul­ti­vate in their chil­dren, hope and opti­mism are the most pre­cious. We can nur­ture hope and opti­mism in our kids by demon­strat­ing that we always have some con­trol over our envi­ron­ment and our­selves. The future isn’t a tide that’s going to crush us, it’s a wave we’re a part of.” — Made­line Levine, author of Ready or Not. Three favorite 2020 books on par­ent­ing and men­tal health

#4. A superb mem­oir on becom­ing a psy­chother­a­py pio­neer and best­selling writer: Becom­ing Myself, by Irvin D. Yalom

#5. This sur­vey of 2500 fam­i­lies about what ADHD treat­ments seem to work/ not work finds that 49% of par­ents report Exer­cise to be ‘Extreme­ly or Very Effec­tive;’ above any oth­er treatment.

#6. On the dan­gers of “pro­duc­tiz­ing” lifestyle guide­lines that help build brain reserve and delay cog­ni­tive prob­lems; Buy­er beware: The sto­ry of a pricey and “cre­den­tialled” pro­gram to end Alzheimer’s Disease

#7. Now, giv­en that “In a new McK­in­sey report, 62% of employ­ees con­sid­er men­tal health issues a top chal­lenge,” it is good to see grow­ing resources and approach­es aimed at address­ing the chal­lenge: Calm rais­es $75 mil­lion, expands into cor­po­rate men­tal health and wellness

#8. And, step by step, dig­i­tal ther­a­peu­tics are going main­stream: Click Ther­a­peu­tics rais­es $30 mil­lion in debt to advance com­mer­cial­iza­tion of smok­ing ces­sa­tion app Clickotine

#9. Nev­er two with­out three: Pear Ther­a­peu­tics rais­es $80M; finds cost sav­ings of $2,150 per patient with opi­oid use disorder

#10. Final­ly, we asked our team and trust­ed advi­sors to com­pile a list of ideas to stay sane and healthy in the months ahead, pri­or­i­tiz­ing habits shown to pro­mote brain health, resilience and pos­i­tive neu­ro­plas­tic­i­ty: Enjoy these 3 New Year Res­o­lu­tions and 36 Ideas for a Hap­pi­er & Health­i­er 2021

Wish­ing you a safe, healthy and hap­py New Year

Reminder: Promoting Brain Health for Life, December 15–16th

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We need a new approach to pro­mote Brain Health for Life: instead of try­ing to treat dis­eases, we need to edu­cate and empow­er the pub­lic at large to adopt life­long healthy lifestyles. In par­al­lel, we need to bet­ter under­stand brain resilience and its mech­a­nisms to design inter­ven­tions that pro­mote it and delay the onset of clin­i­cal man­i­fes­ta­tions of dis­ease, and the con­se­quent dis­abil­i­ty. [Read more…] about Reminder: Pro­mot­ing Brain Health for Life, Decem­ber 15–16th

Save the Date: Promoting Brain Health for Life, December 15–16th, online

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We need a dif­fer­ent, two-pronged approach to address the Brain Health for Life chal­lenge: instead of try­ing to treat dis­eases, we need to focus on pro­mot­ing brain health, edu­cate and empow­er the pub­lic to adopt life­long healthy lifestyles in order to min­i­mize the risk of devel­op­ing psy­chi­atric and neu­ro­log­i­cal dis­eases. In par­al­lel, we need to gain a deep­er under­stand­ing of brain resilience and its mech­a­nisms, to be able to design inter­ven­tions to pro­mote it and delay the onset of clin­i­cal man­i­fes­ta­tions of dis­ease and the con­se­quent dis­abil­i­ty. [Read more…] about Save the Date: Pro­mot­ing Brain Health for Life, Decem­ber 15–16th, online

4 Essential (and Overlooked) Facts About Your Brain and Your Mind

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NeuronsAn aspir­ing clar­inetist begins by get­ting a sense of the way the instrument’s sounds are pro­duced by the air she blows through it. A dri­ver must be acquaint­ed with var­i­ous vehi­cle fun­da­men­tals, such as adding gas, accel­er­at­ing, and read­ing the speedome­ter. It is no dif­fer­ent with the brain. Max­i­miz­ing your brain’s health and per­for­mance begins with a basic under­stand­ing of how it works and how it evolves across the lifespan.

The human brain evolved to help us oper­ate in com­plex, chang­ing envi­ron­ments by con­tin­u­al­ly learn­ing and adapt­ing. Suc­cess­ful­ly doing so involves [Read more…] about 4 Essen­tial (and Over­looked) Facts About Your Brain and Your Mind

Can brain training work? Yes, if it meets these 5 conditions

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brain exerciseIn a mod­ern soci­ety we are con­front­ed with a wide range of increas­ing­ly abstract and inter­con­nect­ed prob­lems. Suc­cess­ful­ly deal­ing with such an envi­ron­ment requires a high­ly fit brain, capa­ble of adapt­ing to new sit­u­a­tions and chal­lenges through­out life. Con­se­quent­ly, we expect cross-train­ing the brain to soon become as main­stream as cross-train­ing the body is today, going beyond unstruc­tured men­tal activ­i­ty and [Read more…] about Can brain train­ing work? Yes, if it meets these 5 conditions