biomarkers

Voice biomarker platform Sonde Health raises $19.25M to spread access to mental health monitoring and beyond

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Voice analy­sis plat­form Sonde Health rais­es $19.25M (Mobi­Health­News):

AI-enabled voice tech­nol­o­gy plat­form Sonde Health announced it raised $19.25 mil­lion in a Series B fund­ing round led by Part­ners Invest­ment, bring­ing its total raise to $35.25 mil­lion … Sonde Health uses patent­ed voice tech­nol­o­gy to detect var­i­ous health con­di­tions from bio­mark­ers in a per­son­’s voice, includ­ing ana­lyz­ing res­pi­ra­to­ry fit­ness and detect­ing depres­sion and anx­i­ety. [Read more…] about Voice bio­mark­er plat­form Sonde Health rais­es $19.25M to spread access to men­tal health mon­i­tor­ing and beyond

Anticholinergic drugs found to significantly increase risk of cognitive decline, especially among those with Alzheimer’s Disease biomarkers or genetic predisposition

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Com­mon Class of Drugs Linked to Increased Risk of Alzheimer’s Dis­ease (UC San Diego release):

A team of sci­en­tists, led by researchers at Uni­ver­si­ty of Cal­i­for­nia San Diego School of Med­i­cine, report that a class of drugs used for a broad array of con­di­tions, from aller­gies and colds to hyper­ten­sion and uri­nary incon­ti­nence, may be asso­ci­at­ed with an increased risk of cog­ni­tive decline, par­tic­u­lar­ly in old­er adults at greater risk for Alzheimer’s dis­ease (AD) … cog­ni­tive­ly nor­mal study par­tic­i­pants who were tak­ing at least one anti­cholin­er­gic drug at base­line were 47 per­cent more like­ly to devel­op mild cog­ni­tive impair­ment (MCI), often a pre­cur­sor to demen­tia such as AD, while being tracked over a peri­od of up to a decade com­pared to par­tic­i­pants who did not take such drugs. [Read more…] about Anti­cholin­er­gic drugs found to sig­nif­i­cant­ly increase risk of cog­ni­tive decline, espe­cial­ly among those with Alzheimer’s Dis­ease bio­mark­ers or genet­ic predisposition

Brain scans show lower accumulation of tau and amyloid pathology among cognitive “super-agers”

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– Tau (blue) and amy­loid (orange) dis­tri­b­u­tion pat­terns for super-agers, nor­mal-agers and MCI patients, when com­pared to a group of younger, healthy, cog­ni­tive­ly nor­mal, amy­loid-neg­a­tive indi­vid­u­als. Cred­it: Mer­le C. Hoenig.

Super-Agers Show Resis­tance to Tau and Amy­loid Accu­mu­la­tion, Main­tain High Cog­ni­tive Func­tion (Soci­ety of Nuclear Med­i­cine and Mol­e­c­u­lar Imag­ing press release):

Super-agers, or indi­vid­u­als whose cog­ni­tive skills are above the norm even at an advanced age, have been found to have increased resis­tance to tau and amy­loid pro­teins, accord­ing to research pre­sent­ed at the Soci­ety of Nuclear Med­i­cine and Mol­e­c­u­lar Imag­ing (SNMMI) 2020 Annu­al Meet­ing. An analy­sis of positron emis­sion tomog­ra­phy (PET) scans has shown that com­pared to nor­mal-agers and those with mild cog­ni­tive impair­ment, super-agers have a low­er bur­den of tau and amy­loid pathol­o­gy asso­ci­at­ed with neu­rode­gen­er­a­tion, which prob­a­bly allows them to main­tain their cog­ni­tive per­for­mance. An image show­ing the com­par­i­son of tau and amy­loid dis­tri­b­u­tion pat­terns in these dif­fer­ent cog­ni­tive aging tra­jec­to­ries has been select­ed as SNMMI’s 2020 Image of the Year. [Read more…] about Brain scans show low­er accu­mu­la­tion of tau and amy­loid pathol­o­gy among cog­ni­tive “super-agers”

Startup Aural Analytics raises $4.3M to monitor neurological health by analyzing speech patterns

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Aur­al Ana­lyt­ics rais­es $4.3M for voice-based cog­ni­tive health mon­i­tor­ing (Mobi­Health­News):

“Aur­al Ana­lyt­ics, a start­up using speech ana­lyt­ics algo­rithms to gauge changes in brain health, has raised $4.3 mil­lion in seed fund­ing … The arti­fi­cial intel­li­gence engine col­lects speech sam­ples through a smart­phone or tablet app, and uploads these to a cloud serv­er for analy­sis. From these, [Read more…] about Start­up Aur­al Ana­lyt­ics rais­es $4.3M to mon­i­tor neu­ro­log­i­cal health by ana­lyz­ing speech patterns

Update: Large study highlights the limited role of genetics in mental health and the importance of effective early interventions

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Dear read­er,

Time for Sharp­Brains month­ly e‑newsletter, dis­cussing the lat­est inno­va­tions for brain health and men­tal health, and open­ing in this occa­sion with a fas­ci­nat­ing study track­ing 2,232 twins over 10+ years.

New research:

New thinking:

New tools:

 

Wish­ing you a great month of December,

 

The Sharp­Brains Team

 

PS: And, here’s a fun brain teaser…ready to stim­u­late those neu­rons in your tem­po­ral lobes?

Tara Thiagarajan, Founder of Brainnovations Winner Sapien Labs, on building a global platform for brain research that truly captures the diversity of humanity

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What sur­prised you the most from the Judges’ ques­tions and feed­back dur­ing the Brain­no­va­tions Pitch Con­test?

I was pleas­ant­ly sur­prised to see the sig­nif­i­cant range and depth of knowl­edge shown by the judg­ing pan­el, lead­ing to very spe­cif­ic and use­ful ques­tions around the key chal­lenges to build our glob­al research platform.

In a nut­shell, what is the core idea behind Sapi­en Labs?

The core idea is to fur­ther our under­stand­ing of the large dif­fer­ences between indi­vid­ual brains in order to man­age our brain health and brain states bet­ter. [Read more…] about Tara Thi­a­gara­jan, Founder of Brain­no­va­tions Win­ner Sapi­en Labs, on build­ing a glob­al plat­form for brain research that tru­ly cap­tures the diver­si­ty of humanity