biochemistry

Working Memory Training can Influence Brain Biochemistry

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I want­ed to alert you to a very inter­est­ing find­ing pub­lished in a recent issue of Sci­ence, one of the world’s lead­ing sci­en­tif­ic journals.

The study was led by Dr. Torkel Kling­berg and his col­leagues from the Karolin­s­ka Insti­tute Torkel Klingbergin Swe­den. The goal was to learn whether Work­ing Mem­o­ry Train­ing is asso­ci­at­ed with changes in brain bio­chem­istry, thus sug­gest­ing a mech­a­nism by which train­ing may lead to enhanced work­ing mem­o­ry capac­i­ty and a reduc­tion in atten­tion prob­lems. Thus, although Work­ing Mem­o­ry Train­ing has pre­vi­ous­ly shown promis­ing results as a treat­ment for work­ing mem­o­ry and atten­tion dif­fi­cul­ties, this was a basic sci­ence study rather than a treat­ment study.

The major find­ing was that increased work­ing mem­o­ry capac­i­ty fol­low­ing train­ing was asso­ci­at­ed with changes in brain bio­chem­istry. Specif­i­cal­ly, the researchers found changes in the den­si­ty and bind­ing poten­tial of cor­ti­cal D1 dopamine recep­tors in brain regions that are acti­vat­ed dur­ing work­ing mem­o­ry tasks.

Results from this study sug­gest a bio­log­i­cal basis for the improve­ment in work­ing mem­o­ry capac­i­ty and reduc­tions i [Read more…] about Work­ing Mem­o­ry Train­ing can Influ­ence Brain Biochemistry

Cognitive Training (Cogmed) Changes the Brain More Than We Thought

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Cog­ni­tive Train­ing Can Alter Bio­chem­istry Of The Brain (Sci­ence Daily)

- “Researchers at the Swedish med­ical uni­ver­si­ty Karolin­s­ka Insti­tute have shown for the first time that the active train­ing of the work­ing mem­o­ry brings about vis­i­ble changes in the num­ber of dopamine recep­tors in the human brain.”

- ““Brain bio­chem­istry does­n’t just under­pin our men­tal activ­i­ty; our men­tal activ­i­ty and think­ing process can also affect the bio­chem­istry,” says Pro­fes­sor Torkel Kling­berg, who led the study.”

- “Changes in the num­ber of dopamine recep­tors in a per­son does­n’t give us the key to poor mem­o­ry,” says Pro­fes­sor Lars Farde, one of the researchers who took part in the study. “We also have to ask if the dif­fer­ences could have been caused by a lack of mem­o­ry train­ing or oth­er envi­ron­men­tal fac­tors. Maybe we’ll be able to find new, more effec­tive treat­ments that com­bine med­ica­tion and cog­ni­tive train­ing, in which case we’re in extreme­ly inter­est­ing territory.”

Com­ment:  could­n’t agree more with “Maybe we’ll be able to find new, more effec­tive treat­ments that com­bine med­ica­tion and cog­ni­tive train­ing, in which case we’re in extreme­ly inter­est­ing ter­ri­to­ry.” This study adds a very impor­tant angle to the grow­ing lit­er­a­ture on work­ing mem­o­ry train­ing, show­ing a more fun­da­men­tal, struc­tur­al impact, that once thought (such as the well-known effect that “cells that fire togeth­er wire togeth­er”). The com­put­er­ized cog­ni­tive pro­gram used in the study was Cogmed work­ing mem­o­ry training.

More on Torkel Kling­berg’s research:

- Arti­cle writ­ten by Torkel Kling­berg on The Over­flow­ing Brain & Infor­ma­tion Overload

- His recent book, which was The Sharp­Brains Most Impor­tant Book of 2008: The Over­flow­ing Brain: Infor­ma­tion Over­load and the Lim­its of Work­ing Memory

- 2006 Inter­view with Dr. Kling­berg: Work­ing Mem­o­ry Train­ing and RoboMemo: Inter­view with Dr. Torkel Klingberg