antidepressant

Study: Antidepressant vortioxetine combined with cognitive training may help delay cognitive decline

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Can Phar­ma­co­log­i­cal Aug­men­ta­tion of Cog­ni­tive Train­ing Reme­di­ate Age-Relat­ed Cog­ni­tive Decline? (The Amer­i­can Jour­nal of Psychiatry):

A grad­ual decline of cog­ni­tive func­tion and con­cur­rent loss of brain vol­ume is an expect­ed process even in healthy aging. What if, how­ev­er, this process could be delayed, reversed, or even pre­vent­ed? This ques­tion has become increas­ing­ly rel­e­vant as the aver­age expect­ed lifes­pan ris­es. Indeed, the num­ber of Amer­i­cans over age 65 is expect­ed to more than dou­ble from 40 mil­lion in 2010 to 89 mil­lion in 2050.

[Read more…] about Study: Anti­de­pres­sant vor­tiox­e­tine com­bined with cog­ni­tive train­ing may help delay cog­ni­tive decline

Machine-learning study finds EEG brain signatures that predict response to antidepressant treatments

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Brain-wave pat­tern can iden­ti­fy peo­ple like­ly to respond to anti­de­pres­sant, study finds (Stan­ford Med­i­cine press release):

“A new method of inter­pret­ing brain activ­i­ty could poten­tial­ly be used in clin­ics to help deter­mine the best treat­ment options for depres­sion, accord­ing to a study led by researchers at the Stan­ford School of Medicine.

Stan­ford researchers and their col­lab­o­ra­tors used elec­troen­cephalog­ra­phy, a tool for mon­i­tor­ing elec­tri­cal activ­i­ty in the brain, and an algo­rithm to iden­ti­fy a brain-wave sig­na­ture in [Read more…] about Machine-learn­ing study finds EEG brain sig­na­tures that pre­dict response to anti­de­pres­sant treatments

Persistence pays off: After 8‑year follow-up, study finds robust and sustained antidepressant response to deep brain stimulation (DBS)

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Long-Term Fol­low-Up Data Shows Deep Brain Stim­u­la­tion Is an Effec­tive Treat­ment for Treat­ment-Resis­tant Depres­sion (Mount Sinai press release):

“A study pub­lished online on Fri­day, Octo­ber 4, in The Amer­i­can Jour­nal of Psy­chi­a­try found that deep brain stim­u­la­tion (DBS) of an area in the brain called the sub­cal­los­al cin­gu­late (SCC) pro­vides a robust anti­de­pres­sant effect that is sus­tained over a long peri­od of time in patients with treat­ment-resis­tant depres­sion [Read more…] about Per­sis­tence pays off: After 8‑year fol­low-up, study finds robust and sus­tained anti­de­pres­sant response to deep brain stim­u­la­tion (DBS)

Therapy or antidepressants? Coming soon: Brain activity “fingerprints” to personalize depression treatments

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mental health.

To Treat Depres­sion, Drugs or Ther­a­py? (The New York Times):

“Until recent­ly, many experts thought that your clin­i­cian could lit­er­al­ly pick any anti­de­pres­sant or type of psy­chother­a­py at ran­dom because, with a few clin­i­cal excep­tions, there was lit­tle evi­dence to favor one treat­ment over anoth­er for a giv­en patient [Read more…] about Ther­a­py or anti­de­pres­sants? Com­ing soon: Brain activ­i­ty “fin­ger­prints” to per­son­al­ize depres­sion treatments

Should Cognitive Behavioural Therapy (not antidepressant drugs) be the first-line treatment for depression?

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Depres­sion: A change of mind (Nature):

“Cog­ni­tive ther­a­py, com­mon­ly known as cog­ni­tive behav­iour­al ther­a­py (CBT), aims to help peo­ple to iden­ti­fy and change neg­a­tive, self-destruc­tive thought pat­terns. And although it does not work for every­one with depres­sion, data have been accu­mu­lat­ing in its favour. “CBT is one of the clear suc­cess sto­ries in psy­chother­a­py,” says Ste­fan Hof­mann, a psy­chol­o­gist at Boston Uni­ver­si­ty in Massachusetts…

Anti­de­pres­sant drugs are usu­al­ly the first-line treat­ment for depres­sion. [Read more…] about Should Cog­ni­tive Behav­iour­al Ther­a­py (not anti­de­pres­sant drugs) be the first-line treat­ment for depression?

To treat depression, we will likely combine neuroplasticity-based brain training games with antidepressants

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BrainTrainingCom­put­er Games Bet­ter Than Med­ica­tion in Treat­ing Elder­ly Depres­sion (Live Science):

“Com­put­er games could help in treat­ing old­er peo­ple with depres­sion who haven’t been helped by anti­de­pres­sant drugs or oth­er treat­ments for the disorder…In a study of 11 old­er patients, researchers found play­ing cer­tain com­put­er games was just as effec­tive at reduc­ing symp­toms of depres­sion as [Read more…] about To treat depres­sion, we will like­ly com­bine neu­ro­plas­tic­i­ty-based brain train­ing games with antidepressants