Should doctors prescribe lecanemab (Leqembi) to women? The answer, given available evidence, is probably No

Data from the CLARITY tri­al ear­li­er this year was sup­posed to be the crown­ing glo­ry of the amy­loid hypoth­e­sis, vin­di­ca­tion for pro­po­nents of this long-held but much-maligned the­o­ry of Alzheimer’s dis­ease. Yet the results left many feel­ing under­whelmed, and even the study authors non­com­mit­tal. The CLARITY tri­al has many admirable fea­tures. It recruit­ed close to…

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