Update on the aducanumab (Aduhelm) saga, retirement, financial advice, cognitive health, excessive worrying, neurotech, and more

Wel­come to a new edi­tion of Sharp­Brains’ e‑newsletter, pro­vid­ing this time a sum­ma­ry of the saga around the FDA approval of adu­canum­ab (Aduhelm) as a sup­posed treat­ment for Alzheimer’s Dis­ease, plus a range of time­ly research find­ings and resources for life­long brain health. First, below are some key reads to nav­i­gate “prob­a­bly the worst drug approval…

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Can the controversial FDA approval of Aduhelm backfire and delay the discovery of actual Alzheimer’s treatments? (Yes, it can)

The U.S. Food and Drug Admin­is­tra­tion (FDA) recent­ly approved adu­canum­ab, the first treat­ment that aims to slow the pro­gres­sion of Alzheimer’s dis­ease. But approval of the drug has pro­voked mixed reac­tions from the sci­en­tif­ic com­mu­ni­ty. Alzheimer’s dis­ease is char­ac­ter­ized by pro­gres­sive mem­o­ry loss, spa­tial dis­ori­en­ta­tion and many oth­er cog­ni­tive and behav­iour­al dis­or­ders that ulti­mate­ly lead…

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US Senator Joe Manchin calls for a new FDA Commissioner to replace current (acting) one who “has repeatedly ignored public health concerns and shown a dereliction of duty” over opioids and aducanumab

Key Demo­c­rat Manchin Bash­es FDA Leader on Alzheimer’s Approval (Bloomberg): Sen­a­tor Joe Manchin, a mod­er­ate Demo­c­rat con­sid­ered a cru­cial vote with­in the party’s slim Sen­ate major­i­ty, said Janet Wood­cock, the tem­po­rary head of the Food and Drug Admin­is­tra­tion, should be quick­ly replaced with a per­ma­nent leader. Manchin blast­ed an FDA deci­sion to approve the controversial…

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Debate: Are depression and dementia two sides of the same coin? And, if they are, how to best approach treatment?

Every sev­en sec­onds, some­one in the world is diag­nosed with demen­tia. A typ­i­cal case that I often see in my prac­tice is as fol­lows: A 76-year-old woman has a two-year his­to­ry of pro­gres­sive wors­en­ing of short-term mem­o­ry and cog­ni­tive decline. She can’t recall the names of her grand­chil­dren and is dev­as­tat­ed by her dete­ri­o­rat­ing abilities.…

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Study: Over-the-counter “brain enhancement” supplements in the US found both to a) contain multiple unapproved drugs and b) lack some ingredients listed on the label

Study: Your Brain Sup­ple­ments Could Con­tain Dan­ger­ous, Ille­gal Ingre­di­ents (Being Patient): Brain sup­ple­ments that claim to boost cog­ni­tive func­tion are increas­ing­ly pop­u­lar, grow­ing from a $4 bil­lion indus­try of about 4,000 unique prod­ucts to a $40 bil­lion indus­try with as many as 80,000 dif­fer­ent prod­ucts on the market. 

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