“Drug makers are making more bets on the nascent field of digital medicine. The latest example: Click Therapeutics announced Monday that it grabbed a $17 million investment led by Sanofi Ventures, the Cambridge, MA-based venture capital arm of the French pharmaceutical giant.
New York-based Click Therapeutics develops mobile apps intended to be prescribed by doctors to treat medical conditions, either on their own or in tandem with drugs or other standard treatments. The six-year-old company is working on software that delivers cognitive and “neurobehavioral” exercises, aimed at treating depression, insomnia, acute coronary syndrome, and chronic pain…Click Therapeutics already has a product on the market. “Clickotine” is an app designed to help people quit smoking, although the product doesn’t make any treatment claims and didn’t require FDA clearance to be marketed to the public, according to a statement e‑mailed by a company spokesperson.
Last year, Click published results of an initial single-arm clinical trial of Clickotine in the JMIR mHealth and uHealth journal. During the eight-week study, the 416 participants opened the app an average of 100 times and continued using it for an average of 5.3 weeks. At the end of the study, 45.2 percent of the participants reported they hadn’t smoked for at least seven days, and 26.2 percent of them said they hadn’t smoked for at least 30 days. The most common side effects were fatigue and mood changes, according to the study.”
Clickotine, A Personalized Smartphone App for Smoking Cessation: Initial Evaluation (JMIR mHealth). From the abstract:
- Background: Tobacco smoking is the leading cause of preventable death in the United States, and the annual economic burden attributable to smoking exceeds US $300 billion. Obstacles to smoking cessation include limited access and adherence to effective cessation interventions. Technology can help overcome these obstacles; many smartphone apps have been developed to aid smoking cessation, but few that conform to the US clinical practice guideline (USCPG) have been rigorously tested and reported in the literature. Clickotine is a novel smartphone app for smoking cessation, designed to deliver the essential features of the USCPG and engineered to engage smokers by personalizing intervention components.
- Objective: Our objective was to assess the engagement, efficacy, and safety of Clickotine in an initial, single-arm study. Outcomes measured were indicators of engagement with the smartphone app (number of app opens, number of interactions with the Clickotine program, and weeks active with Clickotine), cessation outcomes of 7- and 30-day self-reported abstinence from smoking, and negative health events.
- Conclusions: In this initial single-arm trial, Clickotine users appeared to demonstrate encouraging indicators of engagement in terms of the number of app opens, number of program interactions, and continued engagement over time. Clickotine users reported encouraging quit rates while reporting few adverse events. Future research is warranted to assess Clickotine’s efficacy in a randomized controlled trial.
The News in Context:
- Pear Therapeutics raises $50M to develop and market a portfolio of digital therapeutics for mental health
- 10 neurotechnologies about to transform brain enhancement and brain health
- Five reasons the future of brain enhancement is digital, pervasive and (hopefully) bright
- Heads-up: The 2018 SharpBrains Virtual Summit (December 4–6th, 2018) will feature over forty of the world’s top experts, innovators and investors aiming to improve brain health and performance for all in light of growing neuroscience and digital tech.
- Presentation by David Klein, CEO of Click Therapeutics, during the 2017 Brainnovations Pitch Contest: