We are featuring today a 2006 patent, assigned to Advanced Neuromodulation Systems, especially relevant for brain stimulation methods which may carry some negative side effects.
U.S. Patent No. 7,024,247: Systems and methods for reducing the likelihood of inducing collateral neural activity during neural stimulation threshold test procedures.
- Assignee(s): Advanced Neuromodulation Systems, Inc.
- Inventor(s): Bradford Evan Gliner, Kent Leyde
- Technology Category: Transcranial Stimulation
- Issue Date: April 4, 2006
Dealing with the problem of undesirable collateral activity during stimulation treatment, the ‘247 patent describes a “test” stimulation to determine thresholds for both patient responsivity (to the stimulation) and the parameters of a second treatment stimulation (to avoid collateral activity). Despite a short specification with four illustration sheets and six pages of written material, the ‘247 patent recites 55 claims with five independent claims covering various embodiments and versions of the inventive concept. The compelling claim set, along with the synergistic protection afforded when considered in tandem with the ‘305 patent (commonly assigned at the time of this writing) contribute to making the ‘247 patent a key non-invasive neurotechnology patent.
Test procedures for determining a neural stimulation threshold of a patient. In one embodiment, the procedure includes applying a test stimulation signal to the patient and monitoring the patient for a response to the test stimulation signal. The procedure can further include determining a first neural stimulation threshold and calculating a second neural stimulation threshold. The first neural stimulation threshold corresponds to the lowest intensity test stimulation signal that evokes a patient response. The second neural stimulation threshold corresponds to a treatment stimulation signal directed toward affecting a neural activity within the patient.
Illustrative Claim 1. A method of determining a neural stimulation threshold for a patient comprising the steps of:
- applying a test stimulation signal to the patient;
- monitoring the patient for a response to the test stimulation signal;
- determining a first neural stimulation threshold corresponding to a lowest intensity; and
- calculating a second neural stimulation threshold based upon the first neural stimulation threshold, the second neural stimulation threshold corresponding to a treatment stimulation signal directed toward affecting a neural activity within the patient, wherein the treatment stimulation signal differs from at least one test stimulation signal with respect to a plurality of parameters.
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