Tinnitus: Turning Down the Volume (MedPage Today):
“The drug D‑cycloserine was no more effective than placebo when used with a computer-based cognitive training program for relieving persistent ear ringing in patients with tinnitus in a small clinical study, but patients did report fewer cognitive difficulties…
More than 40 million people in the U.S. are believed to be affected by tinnitus, and while there is no cure for the persistent “ringing in the ears” there are treatments that have been shown to be effective in some patients that mask the noise or help patients learn to ignore the sound, Piccirillo told MedPage Today. Cognitive issues such as difficulties with working memory, learning, and attention control are among the most commonly reported symptoms of tinnitus. In one survey, more than 70% of patients with tinnitus reported difficulty concentrating.”
Study: A Novel Treatment for Tinnitus and Tinnitus-Related Cognitive Difficulties Using Computer-Based Cognitive Training and D‑Cycloserine (JAMA Otolaryngology-Head & Neck Surgery). From the abstract:
- Importance: Tinnitus affects more than 40 million people in the Unites States, and cognitive difficulties are among the most commonly associated symptoms.
- Objective: To test the feasibility and preliminarily the effectiveness of using a putative neuroplasticity-enhancing drug, D‑cycloserine, to facilitate a computer-assisted CT program for improving tinnitus bother and related cognitive difficulties.
- Conclusions and Relevance: Use of a computer-based CT program with a putative neuroplasticity-sensitizing drug, D‑cycloserine, was feasible and well tolerated. With the limited sample size, the adjuvant use of D‑cycloserine was no more effective than placebo at improving tinnitus bother. The finding that D‑cycloserine use was more effective than placebo at improving self-reported cognitive difficulties could be important given the high rate of concern for cognitive deficits in patients with tinnitus. D‑cycloserine and other putative neuroplasticity-facilitating agents could be investigated in the future as a strategy to enhance neuroplasticity–based tinnitus treatments.