Mem­ory is more com­plex that we usu­ally think. Cog­ni­tive sci­ences have iden­ti­fied dif­fer­ent mem­ory sys­tems, each sup­ported by dif­fer­ent brain regions. One major dif­fer­ence is between long-term and short-term mem­ory (also called work­ing memory).

Long-term mem­ory is an unlim­ited stor­age of mem­o­ries dat­ing as far back as you can remem­ber to a few min­utes ago. For instance, when you remem­ber your first day in high-school or what you said to your col­league two min­utes ago, you are using your long-term mem­ory sys­tem. This sys­tem depends mostly on parts of the tem­po­ral (in blue here) and frontal (in green) regions of the brain.

Short-term or work­ing mem­ory is a lim­ited stor­age used to briefly keep the infor­ma­tion needed for the task at hand. For instance, when you keep in mind a phone num­ber while you are dial­ing it or when you do some men­tal cal­cu­la­tion you are using your work­ing mem­ory sys­tem. This sys­tem depends mostly on parts of the frontal (in green) and pari­etal (in yel­low) regions of the brain.

Work­ing mem­ory is cru­cial for most of the tasks we per­form daily. It is also quite vul­ner­a­ble to the aging process. Two good rea­sons to try to main­tain this func­tion! Ready to test and sharpen your short-term memory?

Fol­low this link to mem­o­rize series of let­ters. The first 2 tri­als are very easy but the test gets quite chal­leng­ing after that!

Every Mon­day dur­ing the next 10 weeks we’ll dis­cuss here what lead­ing indus­try, sci­ence and pol­icy experts –all of whom will speak at the upcom­ing 2011 Sharp­Brains Sum­mit (March 30th — April 1st, 2011)– have to say about emerg­ing oppor­tu­ni­ties and chal­lenges to address, over the next 10 years, the grow­ing brain-related soci­etal demands.

With­out fur­ther ado, here you have what four Sum­mit Speak­ers say…

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Alvaro Pascual-Leone is the Direc­tor of the Berenson-Allen Cen­ter for Non-Invasive Brain Stim­u­la­tion at Har­vard Med­ical School.

1. How would you define “brain fit­ness” vs. “phys­i­cal fit­ness”?

Phys­i­cal fit­ness can refer to an over­all or gen­eral state of health and well-being. How­ever, it is also often used more specif­i­cally to refer to the abil­ity to per­form a given activ­ity, occu­pa­tion, or sport.

Sim­i­larly brain fit­ness might be used to refer to a gen­eral state of healthy, opti­mized brain func­tion, or a more spe­cific brain-based abil­ity to process cer­tain, spe­cific infor­ma­tion, enable cer­tain motor actions, or sup­port cer­tain cog­ni­tive abil­i­ties. Impor­tantly though, I would argue Read the rest of this entry »

Work­ing mem­ory (WM) is the cog­ni­tive sys­tem respon­si­ble for the tem­po­rary stor­age and manip­u­la­tion of infor­ma­tion and plays an impor­tant role in both learn­ing and focus­ing atten­tion. Con­sid­er­able research has doc­u­mented that many chil­dren and adults with ADHD have WM deficits and that this con­tributes to dif­fi­cul­ties asso­ci­ated with the dis­or­der. For an excel­lent intro­duc­tion to the role of WM deficits in ADHD, click here.

A sim­ple exam­ple illus­trates the impor­tance of WM for par­tic­u­lar aca­d­e­mic tasks. Try adding 3 and 9 in your head. That was prob­a­bly easy for you. Now try­ing adding 33 and 99. That was prob­a­bly more dif­fi­cult. Finally, try adding 333 and 999. This is quite chal­leng­ing for most adults even though each cal­cu­la­tion required is triv­ially easy. The chal­lenge occurred because you need to store infor­ma­tion — the sum of 3+9 in the one’s col­umn and then ten’s col­umn — as you process the remain­ing part of the prob­lem, i.e., 3+9 in the hundred’s col­umn, and this taxed your WM. If your WM capac­ity was exceeded, you could not com­plete the prob­lem successfully.

This sim­ple prob­lem also illus­trates the dif­fer­ence between short-term mem­ory (STM) and WM. Short-term mem­ory sim­ply involves retain­ing infor­ma­tion in mind for short peri­ods of time, e.g., remem­ber­ing that the prob­lem you need to solve is 333+999. Work­ing mem­ory, in con­trast, involves men­tally manip­u­lat­ing — or ‘work­ing’ with — retained infor­ma­tion and comes into play in a wide range of learn­ing activ­i­ties. For exam­ple, to answer ques­tions about a sci­ence chap­ter, a child not only has to cor­rectly retain fac­tual infor­ma­tion but must men­tally work with that infor­ma­tion to answer ques­tions about it. Thus, when a child’s WM capac­ity is low rel­a­tive to peers, aca­d­e­mic per­for­mance is likely to be com­pro­mised in mul­ti­ple areas.

Because WM deficits play an impor­tant role in the strug­gles expe­ri­enced by many indi­vid­u­als with ADHD, it is impor­tant to con­sider how dif­fer­ent inter­ven­tions address this aspect of the dis­or­der. In this study, the authors were inter­ested in com­par­ing the impact of Work­ing Mem­ory Train­ing and stim­u­lant med­ica­tion treat­ment on the WM per­for­mance of chil­dren diag­nosed with ADHD.

Par­tic­i­pants were 25 8–11 year-old chil­dren with ADHD (21 boy and 4 girls) who were being treated with stim­u­lant med­ica­tion. Children’s mem­ory per­for­mance was assessed on 4 occa­sions using the Auto­mated Work­ing Mem­ory Assess­ment (AWMA), a com­put­er­ized test that mea­sures ver­bal short-term mem­ory, ver­bal work­ing mem­ory, visuo-spatial short-term mem­ory, and visuo-spatial work­ing memory.

At time 1, the assess­ment was con­ducted when chil­dren had been off med­ica­tion for at least 24 hours. The sec­ond assess­ment occurred an aver­age of 5 months later and when chil­dren were on med­ica­tion. The third assess­ment occurred after chil­dren had com­pleted 5 weeks of Cogmed Work­ing Mem­ory Train­ing using the stan­dard train­ing pro­to­col (see below). The final assess­ment occurred approx­i­mately 6 months after train­ing had ended. This design enabled the researchers to make the fol­low­ing comparisons:

- WM per­for­mance on med­ica­tion vs. off med­ica­tion (T1 vs T2)
– WM per­for­mance on med­ica­tion vs. after train­ing (T2 vs. T3)
– WM per­for­mance imme­di­ately after train­ing ended vs. 6 months fol­low­ing train­ing (T3 vs. T4)

This final com­par­i­son pro­vided infor­ma­tion on whether any ben­e­fits pro­vided by the train­ing had endured.

In addi­tion to mea­sur­ing STM and WM at each time point, mea­sures of IQ were col­lected at times 1, 2, and 3.

- Work­ing Mem­ory Train­ing -

WM train­ing was con­ducted using the stan­dard Cogmed train­ing pro­to­col with each child com­plet­ing 20–25 train­ing ses­sions within a 25 day period. The train­ing requires the stor­age and manip­u­la­tion of sequences of ver­bal, e.g., repeat­ing back a sequence of dig­its in reverse order, and/or visuo-spatial infor­ma­tion, e.g., recall­ing the loca­tion of objects on dif­fer­ent por­tions of the com­puter screen.

Dif­fi­culty level is cal­i­brated on a trial by trial basis so the child is always work­ing at a level that closely matches their per­for­mance. For exam­ple, if a child suc­cess­fully recalled three dig­its in reverse order, on the next trial he had to recall four. When a trial was failed, the next trial was made eas­ier by reduc­ing the num­ber of items to be recalled. This method of ‘adap­tive train­ing’ is thought to be a key ele­ment because it requires the child to ‘stretch’ their WM capac­ity to move through the program.

- Results -

- Impact of Short-Term Mem­ory and Work­ing Mem­ory -

Med­ica­tion vs. no med­ica­tion — When tested on med­ica­tion, Read the rest of this entry »

There are whole mar­kets (think cross­words, herbal sup­ple­ments, drugs, brain fit­ness soft­ware) aimed at help­ing us improve our memory.

Now, what is “mem­ory”? how does the process of mem­ory work?

Dr. Bill Klemm, Pro­fes­sor of Neu­ro­science at Texas A&M Uni­ver­sity, explains a very impor­tant con­cept below.

- Alvaro

——-

Get­ting from Here to There:
Mak­ing Mem­ory Con­sol­i­da­tion Work

By Bill Klemm,  Ph. D.

Until con­sol­i­da­tion has occurred, a short-term mem­ory is very vul­ner­a­ble, as all of us have expe­ri­enced from look­ing up a phone num­ber only to have some dis­trac­tion cause us to lose the num­ber before we can get it dialed.

What is “consolidation”?

Brain researchers use the term “con­sol­i­da­tion” for the process whereby short-term mem­ory gets made more permanent.

Here, I would like to dis­cuss some aspects of con­sol­i­da­tion that many peo­ple may not know about: why sleep is so impor­tant, why mem­ory must be prac­ticed, and how test­ing pro­motes con­sol­i­da­tion. Read the rest of this entry »

How many dif­fer­ences can you spot?

You have seen and maybe tried that exer­cise or game in the Sun­day paper many times: find 5 dif­fer­ences between the two images.

You may like it or not. You may think it is only for kids. But it is a GREAT brain exercise!

Let’s see what cog­ni­tive processes and which brain areas are involved in this exercise:

Read the rest of this entry »