New Con­cus­sion Guide­lines Stress Indi­vid­ual Treat­ment (The New York Times):
“The Amer­i­can Acad­emy of Neu­rol­ogy said Mon­day that it had revised its guide­lines for han­dling con­cus­sions to empha­size treat­ing ath­letes case by case rather than accord­ing to a pre­de­ter­mined scale…In not­ing that more than a mil­lion Amer­i­can ath­letes Read the rest of this entry »

We are the archi­tects and builders of our own brains.

For mil­len­nia, how­ever, we were obliv­i­ous to our enor­mous cre­ative capa­bil­i­ties. We had no idea that our brains were chang­ing in response to our actions and atti­tudes, every day of our lives. So we uncon­sciously and ran­domly shaped our brains and our lat­ter years because we believed we had an immutable brain that was at the mercy of our genes.

Noth­ing could be fur­ther from the truth. Read the rest of this entry »

‘Chemo Brain’: MRI Shows Brain Changes After Chemother­apy (Medscape):

- “Breast can­cer sur­vivors who have been treated with chemother­apy show sig­nif­i­cant changes in brain activ­ity, mea­sured by func­tional mag­netic res­o­nance imag­ing (fMRI), accord­ing to a study pub­lished in the Novem­ber issue of the Archives of Neu­rol­ogy.”

- “The find­ing val­i­dates patients’ claims of reduced cog­ni­tive func­tion after receiv­ing chemother­apy, a phe­nom­e­non referred to as “chemo brain,” said lead author Shelli R. Kesler, PhD, from Stan­ford Uni­ver­sity School of Med­i­cine in California.”

Link to study Pre­frontal Cor­tex and Exec­u­tive Func­tion Impair­ments in Pri­mary Breast Can­cer (Archives of Neu­rol­ogy): Read the rest of this entry »

We men­tioned in our recent mar­ket report that NovaV­i­sion had declared bank­rupcy. The com­pany tried to trans­form its busi­ness model in the last cou­ple of years — obvi­ously it didn’t work. Now the trustee is shar­ing a few more details and look­ing for ways to dis­pose of its assets:

NovaVision’s FDA-Cleared Visual Restora­tion Ther­apy (VRT) Sys­tem and Com­pany Assets Now Avail­able (press release)

The bank­ruptcy trustee has engaged The Mag­num Group, Inc., to solicit offers for NovaVision’s assets which include the NovaV­i­sion Visual Restora­tion Ther­apy (VRT) sys­tem, a neu­ro­plac­tic­ity (sic) plat­form that has been cleared by the U.S. Food and Drug Admin­is­tra­tion (FDA) for the treat­ment of stroke, trau­matic brain injury, ambly­opia (“lazy eye”) and optic nerve damage.

NovaV­i­sion has received a total invest­ment of $49,200,000 since its found­ing in 2003 and has gen­er­ated rev­enues of approx­i­mately $1,000,000 each year for the past three years. The company’s non-invasive computer-based neu­ro­plac­tic­ity (sic) prod­ucts have treated more than 3,000 patients world­wide. NovaV­i­sion esti­mates the total mar­ket oppor­tu­nity for its port­fo­lio of prod­ucts to exceed 300,000 units in U.S. optom­e­try, oph­thal­mol­ogy, neu­rol­ogy, and pri­mary care prac­tices as well as reha­bil­i­ta­tion centers.

In a recently pub­lished sci­en­tific study (see Hall C, et al “Cog­ni­tive activ­i­ties delay onset of mem­ory decline in per­sons who develop demen­tia” Neu­rol­ogy 2009; 73: 356–361), Hall and col­leagues exam­ined how edu­ca­tion and stim­u­lat­ing activ­i­ties may inter­act to con­tribute to cog­ni­tive reserve. The study involved 488 ini­tially healthy peo­ple, aver­age age 79, who enrolled in the Bronx Aging Study between 1980 and 1983. These indi­vid­u­als were fol­lowed for 5 years with assess­ments every 12 to 18 months (start­ing in 1980). At the start of the study, all par­tic­i­pants were asked how many cog­ni­tive activ­i­ties (read­ing, writ­ing, cross­word puz­zles, board or card games, group dis­cus­sions, or play­ing music) they par­tic­i­pated in and for how many days a week. Researchers were able to eval­u­ate the impact of self-reported par­tic­i­pa­tion these activ­i­ties on the onset of accel­er­ated mem­ory decline in 101 indi­vid­u­als who devel­oped demen­tia dur­ing the study.

Results showed that for every “activ­ity day” (par­tic­i­pa­tion in one activ­ity for one day a week) the sub­jects engaged in, they delayed for about two months the onset of rapid mem­ory loss asso­ci­ated with demen­tia. Inter­est­ingly, the pos­i­tive effect of brain-stimulating activ­i­ties in this study appeared to be inde­pen­dent of a person’s level of education.

This is great news as it sug­gests that it is never too late to try to build up brain reserve. The more brain stim­u­lat­ing activ­i­ties one does and the more often, the bet­ter for a stronger cog­ni­tive reserve.

The cog­ni­tive reserve hypoth­e­sis sug­gests that indi­vid­u­als with more cog­ni­tive reserve can expe­ri­ence more Alzheimer’s dis­ease pathol­ogy in the brain (more plaques and tan­gles) with­out devel­op­ing Alzheimer’s dis­ease symptoms.

How does that work? Sci­en­tists are not sure but two pos­si­bil­i­ties are con­sid­ered.
1. One is that more cog­ni­tive reserve means more brain reserve, that is more neu­rons and con­nec­tions between neu­rons.
2. Another pos­si­bil­ity is that more cog­ni­tive reserve means more com­pen­satory processes (see my pre­vi­ous post “Edu­ca­tion builds Cog­ni­tive Reserve for Alzheimers Dis­ease Pro­tec­tion” for more details.)

Now, one may won­der about the dif­fer­ence types of men­tal stim­u­la­tion avail­able, includ­ing not only puz­zles and such, but struc­tured activ­i­ties such as brain fit­ness soft­ware and med­i­ta­tion. Do we exer­cise our brain every time we think about some­thing? What can one do to exer­cise one’s brain in ways that enhance capac­ity? Does aer­o­bic fit­ness train­ing also exer­cise one’s brain? What types of method­olo­gies and prod­ucts are avail­able? Do they “work”? Are all the same?

Those are the types of ques­tions we wanted to address in the book The Sharp­Brains Guide To Brain Fit­ness (avail­able via Amazon.com). We are proud of the recog­ni­tion the book has started to obtain, includ­ing endorse­ments by lead­ing scientists:

“The Sharp­Brains Guide to Brain Fit­ness is the only book that I know of that seam­lessly inte­grates lat­est infor­ma­tion about cog­ni­tive health across the lifes­pan, with inter­views with active researchers exam­in­ing cog­ni­tive main­te­nance and enhance­ment, along with reviews of com­mer­cial prod­ucts tar­geted to cog­ni­tive enhance­ment. The book should be very use­ful to any­one inter­ested in brain care, both health care pro­fes­sion­als and the pub­lic at large”.
— Arthur Kramer, Pro­fes­sor of Psy­chol­ogy at Uni­ver­sity of Illinois

“This Sharp­Brains book pro­vides a very valu­able ser­vice to a wide com­mu­nity inter­ested in learn­ing and brain top­ics. I found it inter­est­ing and help­ful“
- Michael Pos­ner, Emer­i­tus Pro­fes­sor of Neu­ro­science at the Uni­ver­sity of Ore­gon, and first recip­i­ent of the Dogan Prize

– Pas­cale Mich­e­lon, Ph. D., is Sharp­Brains’ Research Man­ager for Edu­ca­tional Projects. Dr. Mich­e­lon has a Ph.D. in Cog­ni­tive Psy­chol­ogy and has worked as a Research Sci­en­tist at Wash­ing­ton Uni­ver­sity in Saint Louis, in the Psy­chol­ogy Depart­ment. She con­ducted sev­eral research projects to under­stand how the brain makes use of visual infor­ma­tion and mem­o­rizes facts. She is now an Adjunct Fac­ulty at Wash­ing­ton University.

Ref­er­ences:

- Study: Hall C, et al “Cog­ni­tive activ­i­ties delay onset of mem­ory decline in per­sons who develop demen­tia” Neu­rol­ogy 2009; 73: 356–361

- Book: The Sharp­Brains Guide To Brain Fit­ness: 18 Inter­views with Sci­en­tists, Prac­ti­cal Advice, and Prod­uct Reviews, to Keep Your Brain Sharp

Here you have the March edi­tion of our monthly newslet­ter cov­er­ing cog­ni­tive health and brain fit­ness top­ics. Please remem­ber that you can sub­scribe to receive this Newslet­ter by email, using the box at the top of this page. I know I am biased — but do believe this Newslet­ter issue might well be our best so far. I hope you find the time to enjoy it!

Bird’s Eye View

Brain Fit­ness Sur­vey: Over 2,000 thought­ful responses to our Jan­u­ary sur­vey (Thank You!) rein­force the need for pub­lic aware­ness ini­tia­tives and qual­ity infor­ma­tion to help eval­u­ate and nav­i­gate lifestyle and prod­uct claims, as well as the need for more research, an expanded health­care cul­ture, as more. Given this con­text, we are pub­lish­ing The Sharp­Brains Guide to Brain Fit­ness in May 2009, a book with 18 Inter­views with Sci­en­tists, Prac­ti­cal Advice, and Prod­uct Reviews, in addi­tion to our annual mar­ket report for pro­fes­sion­als and exec­u­tives (to be pub­lished in April). If you have ideas to help us pro­mote the book, please reply to this email and let us know!

Life­long Learning

“What­ever you strug­gle with in a sense as it stems from your neu­rol­ogy, the inher­ent plas­tic­ity of the brain gives you a basis for improve­ment. This is a way under­uti­lized and under-appreciated resource that well all have.” Dr. Michael Merzenich on the Brain Sci­ence Pod­cast #54, 2/13/09.

Recently there has been grow­ing con­tro­versy about the effec­tive­ness of computer-based cog­ni­tive train­ing pro­grams. As a co-founder of Posit Sci­ence, Inc. Dr. Michael Merzenich is a staunch defender of the meth­ods his com­pany uses to val­i­date the pro­grams that they have devel­oped. But for the pur­poses of this essay, I want to share some of the key ideas we dis­cussed dur­ing his recent inter­view on the Brain Sci­ence Podcast.

First of all, I asked him to dis­cuss some of the high­lights of his long career. Since he was one of the first neu­ro­sci­en­tists to embrace the con­cepts of neu­ro­plas­tic­ity I was curi­ous about how this came about. While he did have some expo­sure to the ani­mal evi­dence as a grad­u­ate stu­dent, it was actu­ally his expe­ri­ence with the inven­tion of the cochlear implant that con­vinced Dr. Merzenich of the real-world, prac­ti­cal impli­ca­tions of brain plas­tic­ity. The qual­ity of the Read the rest of this entry »