ADHD is the most com­monly diag­nosed neu­robe­hav­ioral dis­or­der in chil­dren and sub­stan­tial evi­dence indi­cates that bio­log­i­cal fac­tors play an impor­tant role in its devel­op­ment. For exam­ple, although the exact mech­a­nism by which genetic fac­tors con­vey increased risk for ADHD remains unclear, the impor­tance of genetic trans­mis­sion has been doc­u­mented in a num­ber of pub­lished studies.

Even though bio­log­i­cal fac­tors are widely regarded as impor­tant in the devel­op­ment of ADHD, no med­ical or bio­log­i­cal test is rec­om­mended for rou­tine use when diag­nos­ing ADHD. Instead, Read the rest of this entry »

We have always thought that “our brain shapes us.” I wrote my new book, The Woman Who Changed Her Brain (May 2012; Free Press, Fore­word by Nor­man Doidge), to prove that the reverse is equally true. I wanted to demon­strate how “we can shape our brains.”

Imag­ine hav­ing a brain that is capa­ble and inca­pable at the same time. Grow­ing up, I had severe learn­ing dis­abil­i­ties. I lived in a world that was con­fus­ing and incom­pre­hen­si­ble. As I was to later dis­cover, a crit­i­cal part of my brain was not work­ing prop­erly, the end result being that all lan­guage was expe­ri­enced as for­eign and my trans­la­tor was Read the rest of this entry »

(Editor’s note: below you have the final part of the 6-part Stress and the Brain series. If you are join­ing the series now, you can read the pre­vi­ous parts via the links below.)

Stayin’ Alive

TO FIGHT, FLEE, OR FREEZE — THAT IS THE QUESTION

With a bet­ter under­stand­ing of the neu­ro­bi­ol­ogy of stress, the LD — ADHD — stress con­nec­tion becomes clear.  Stu­dents with learn­ing dis­abil­i­ties or ADHD, con­fronted with the stress cre­ated by expo­sure to tasks that are in real­ity or in their per­cep­tion too dif­fi­cult (and thus threat­en­ing), exhibit the pro­tec­tive behav­ior of any organ­ism under extreme stress:  They fight, they flee, or they freeze. When these kids don’t under­stand why they can’t do what other kids can do (mas­ter the stres­sor), and they can’t see any way to get out of a sit­u­a­tion that won’t go away, they begin to shut down. Read the rest of this entry »

(Editor’s note: below you have part 5 of the 6-part The Neu­ro­bi­ol­ogy of Stress series. If you are join­ing the series now, you can read the pre­vi­ous part Here.)

Stayin’ Alive

The Human Brain Likes to Be in Balance

For­tu­nately, the brain has some built — in safety sys­tems. Too much cor­ti­sol in the blood sig­nals the brain and adrenal glands to decrease cor­ti­sol pro­duc­tion. And under nor­mal con­di­tions, when the stress is over­come or brought under con­trol (by fight­ing, flee­ing, or turn­ing into an immo­bile statue, or by mas­ter­ing the threat), the hypo­thal­a­mus starts send­ing out the orders to stand down. Stop pro­duc­ing cor­ti­sol!  Event over!  Under con­tin­u­ous stress, how­ever, this feed­back sys­tem breaks down. The hypo­thal­a­mus keeps read­ing the stress as a threat, furtively send­ing mes­sages to the pitu­itary gland, which screams out to the adrenal glands to keep pump­ing out cor­ti­sol, which at this point begins to be neu­ro­toxic — poi­son to the brain. Read the rest of this entry »

(Editor’s note: below you have part 4 of the 6-part The Neu­ro­bi­ol­ogy of Stress series. If you are join­ing the series now, you can read the pre­vi­ous part Here.)

Stayin’  Alive

THE STRESS RESPONSE EXPLAINED

Stress was put on the map, so to speak, by a Hun­gar­ian — born Cana­dian endocri­nol­o­gist named Hans Hugo Bruno Selye (ZEL — yeh) in 1950, when he pre­sented his research on rats at the annual con­ven­tion of the Amer­i­can Psy­cho­log­i­cal Asso­ci­a­tion. To explain the impact of stress, Selye pro­posed some­thing he called the Gen­eral Adap­ta­tion Syn­drome (GAS), which he said had three com­po­nents. Accord­ing to Selye, when an organ­ism expe­ri­ences some novel or threat­en­ing stim­u­lus it responds with an alarm reac­tion. This is fol­lowed by what Selye referred to as the recov­ery or resis­tance stage, a period of time dur­ing which the brain repairs itself and stores the energy it will need to deal with the next stress­ful event.

Read the rest of this entry »

(Editor’s note: below you have part 3 of the 6-part The Neu­ro­bi­ol­ogy of Stress series. If you are join­ing the series now, you can read the pre­vi­ous part Here.)

Stayin’ Alive

Under­stand­ing the Human Brain and How It Responds to Stress

The Lit­tle Brain Down Under

The tour con­tin­ues … Sit­ting under the occip­i­tal and tem­po­ral lobes of the brain is the cere­bel­lum. It’s about the size of a child’s fist. Because it looks like a sep­a­rate brain­like struc­ture attached to the under­side of the cor­tex, the cere­bel­lum is some­times referred to as the “ lit­tle brain. ” It’s con­nected to the brain stem, which in turn con­nects the brain to the spinal cord. The cere­bel­lum used to be rel­e­gated to the very sim­ple role of help­ing us main­tain bal­ance when we walk or run, but mod­ern neu­ro­science has found that the cere­bel­lum plays a much larger and more impor­tant role than that. Read the rest of this entry »

(Editor’s note:  below you have part 2 of the 6-part The Neu­ro­bi­ol­ogy of Stress series. If you are join­ing the series now, you can read the pre­vi­ous part Here.)

Stayin’ Alive

Gray Mat­ters

The term gray mat­ter usu­ally evokes an image of the cor­tex, because that ’ s the part most vis­i­ble in pic­tures of the brain.  In fact, gray mat­ter makes up not only the cere­bral cor­tex but also the cen­tral por­tion of the spinal cord and areas called the cere­bel­lar cor­tex and the hip­pocam­pal cor­tex.  This dense tis­sue is packed full of neu­ronal cells, their den­drites (branch­ing, root — like end­ings), axon ter­mi­nals (the other end), and those sticky glial cells I men­tioned ear­lier. The cor­tex is the area of the brain where the actual pro­cess­ing of infor­ma­tion takes place.  Because of its rel­a­tive size and com­plex­ity, it ’ s easy to under­stand why it plays a key role in mem­ory, atten­tion, per­cep­tual aware­ness, thought, lan­guage, and consciousness.

Read the rest of this entry »