Sharon Beg­ley, Newsweek’s sci­ence reporter, recently wrote that

- “With the nation’s 78 mil­lion baby boomers approach­ing the age of those dreaded ‘“where did I leave my keys?” moments, it’s no won­der the mar­ket for computer-based brain train­ing has shot up from essen­tially zero in 2005 to $80 mil­lion this year, accord­ing to the con­sult­ing firm SharpBrains.

- “Now comes the largest and most rig­or­ous study of a commercially-available train­ing pro­gram, and it shows that there is hope for aging brains. This morn­ing, at the meet­ing of the Geron­to­log­i­cal Soci­ety of Amer­ica, sci­en­tists are pre­sent­ing data show­ing that after eight weeks of daily one-hour ses­sions with Brain Fit­ness 2.0 from Posit Sci­ence, elderly vol­un­teers got mea­sur­ably bet­ter in their brain’s speed and accu­racy of processing.

We recently had the chance to inter­view Dr. Eliz­a­beth Zelin­ski of the Uni­ver­sity of South­ern Cal­i­for­nia Andrus Geron­tol­ogy Cen­ter, who led the IMPACT (Improve­ment in Mem­ory with Plasticity-based Adap­tive Cog­ni­tive Train­ing) Study Sharon Beg­ley refers to in the quote above.

First, some con­text on this study, which is by far the largest high-quality study of its kind. The study was prospec­tive, ran­dom­ized, con­trolled, and used a dou­ble blind trial. 524 healthy adults 65-year-old and over were divided into two groups. One received an hour a day of train­ing for eight to ten weeks, and the other spent the same amount of time watch­ing edu­ca­tional DVDs. The IMPACT study, funded by Posit Sci­ence cor­po­ra­tion, was per­formed in mul­ti­ple loca­tions, includ­ing the Mayo Clinic, USCF, and San Fran­cisco Vet­eran Affairs Med­ical Center.

The dis­cus­sion cen­ters at his point on the ini­tial results that were pre­sented Geron­to­log­i­cal Soci­ety of Amer­ica (the study hasn’t been pub­lished yet).

Alvaro Fer­nan­dez: Dr. Zelin­ski. Thank you for being with us. Could you start by set­ting the con­text and pro­vid­ing an overview of how human cog­ni­tive abil­i­ties typ­i­cally evolve as we age based on insights from your Long Beach Lon­gi­tu­di­nal Study?

Eliz­a­beth Zelin­ski: Of course. The first con­cept to under­stand is that dif­fer­ent cog­ni­tive skills evolve over the lifes­pan in dif­fer­ent ways. Some that rely on expe­ri­ence, such as vocab­u­lary, actu­ally improve as we age. Some tend to decline grad­u­ally, start­ing in our late 20s. This hap­pens, for exam­ple, with pro­cess­ing speed (how long it takes us to process and respond to infor­ma­tion), mem­ory, and rea­son­ing. We could sum­ma­rize this phe­nom­e­non by say­ing that as we age we get bet­ter at deal­ing with the famil­iar, but worse at deal­ing with the new. We can always learn, but at a slower pace.

Are there any spe­cific tip­ping or inflec­tion points in this trend, any age when the rate of decline is more pronounced?

We don’t have a clear answer to that. It depends a lot on the indi­vid­ual. In gen­eral it is a grad­ual, cumu­la­tive process, so that by age 70 we sta­tis­ti­cally see clear age declines. Which, for exam­ple, is a strong fac­tor deter­min­ing why older adults strug­gle to adapt to new tech­nolo­gies, but why try­ing to learn them pro­vides needed men­tal stim­u­la­tion. Now we know that genes only account for a por­tion of this decline. Much of it depends on our envi­ron­ment, lifestyle and actions.

Can you sum­ma­rize what a healthy indi­vid­ual can do to slow down this process of decline, and help stay healthy and pro­duc­tive as long as possible?

One gen­eral rec­om­men­da­tion is to do every­thing we can to pre­vent or delay dis­ease processes, such as dia­betes or high-blood pres­sure, that have a neg­a­tive effect on our brains. For exam­ple, it is a tragedy in our soci­ety that we usu­ally reduce our lev­els of phys­i­cal exer­cise dras­ti­cally after we leave school.

Let me then ask: what are the rel­a­tive virtues of phys­i­cal vs. men­tal exercise?

Great ques­tion! That in fact leads into my sec­ond rec­om­men­da­tion. Aer­o­bic exer­cise has been shown to be a great con­trib­u­tor to over­all cog­ni­tive health. But it has not shown any sig­nif­i­cant effect on improved mem­ory. This is an impor­tant point to remem­ber: there have been dozens of stud­ies on the impact of phys­i­cal exer­cise on cog­ni­tion and they have found many impacts, but none in the area of mem­ory. In con­trast, directed cog­ni­tive train­ing, or “men­tal exer­cise”, has been shown to improve spe­cific cog­ni­tive abil­i­ties, includ­ing memory.

Now, there is no magic bul­let: both are impor­tant com­po­nents. And I would add a third ele­ment: it is also impor­tant to main­tain emo­tional con­nec­tions. Not only with our­selves, to have self-confidence and self-esteem, but with our fam­ily our friends.

Let’s talk now about the IMPACT study ini­tial results. What results sur­prised you the most?

Prob­a­bly the most sur­pris­ing out­come was a clear trans­fer of the train­ing, which is crit­i­cal so that the cog­ni­tive improve­ments have an impact on every­day life. The pro­gram we used, Brain Fit­ness 2.0, trains audi­tory pro­cess­ing. The peo­ple in the exper­i­men­tal group improved very sig­nif­i­cantly, which was not that sur­pris­ing. What was very sur­pris­ing was that there was also a clear ben­e­fit in audi­tory mem­ory, which wasn’t directly trained. In other words, peo­ple who were 75-years-old per­formed audi­tory mem­ory tasks as well as aver­age 65-year-olds, so we can say they reversed 10 years of aging for that cog­ni­tive ability.

Another area where peo­ple in the exper­i­men­tal group showed sig­nif­i­cant improve­ment was in self-reported per­cep­tion of their abil­i­ties in a vari­ety of daily life tasks, such as remem­ber­ing names and phone num­bers, where they had left their keys, as well as com­mu­ni­ca­tion abil­i­ties and feel­ings of self-confidence.

Those results, even if ini­tial, are impres­sive and have very sig­nif­i­cant impli­ca­tions. Let’s now spec­u­late a bit about the future. We have said that dif­fer­ent cog­ni­tive abil­i­ties evolve in dif­fer­ent ways, and we have talked about just a few of them. We have dis­cussed how phys­i­cal exer­cise can be use­ful. And how directed cog­ni­tive train­ing may help improve spe­cific cog­ni­tive skills, like the Brain Fit­ness 2.0 pro­gram devel­oped by Dr. Michael Merzenich. Other exam­ples include work­ing mem­ory train­ing, shown by Dr. Torkel Kling­berg, and atten­tional con­trol, by Dr. Daniel Gopher. In the future, will we have access to bet­ter assess­ments and tools to iden­tify and train the cog­ni­tive abil­i­ties we need to work on the most, in the same way that we can go to a gym today and find the com­bi­na­tion of machines that pro­vide the most effec­tive per­son­al­ized workout?

The phys­i­cal fit­ness anal­ogy is a good one, in that cog­ni­tive enhance­ment requires the engage­ment in a vari­ety of activ­i­ties, those activ­i­ties must be novel, adap­tive and challenging-which is why computer-based pro­grams can be help­ful. But even at a more basic level, what mat­ters is being engaged with life, con­tin­u­ally exposed to stim­u­lat­ing activ­i­ties, always try­ing to get out of our com­fort zones, doing our best at what­ever we are doing. A major typ­i­cal mis­con­cep­tion is that there is only one gen­eral intel­li­gence to care about. In real­ity, we have many dif­fer­ent cog­ni­tive abil­i­ties, such as atten­tion, mem­ory, lan­guage, rea­son­ing, and more, so it makes sense to have dif­fer­ent pro­grams designed to train and improve each of them. Before embark­ing on this study I was skep­tic about what we would find. Now I believe cog­ni­tive train­ing is a very promis­ing area that deserves more sci­en­tific and pol­icy attention.

Dr. Zelin­ski, thank you for your time. When do you expect your paper will be pub­lished, so we can ana­lyze it in more detail?

You are wel­come. I think the paper will be sub­mit­ted for pub­li­ca­tion in the next cou­ple of months.  We won’t know where until it’s been peer reviewed and accepted. Will let you know as soon as I do.

————————————————————

More read­ing

- see Poster results pre­sented at GSA

- read more inter­views in our Neu­ro­science and Psy­chol­ogy Inter­view Series

- Brain Fit­ness: Novem­ber Monthly Digest: a col­lec­tion of arti­cles and links includ­ing news, resources, brain teasers, and more.

Be Socia­ble, Share!

•