The Dana Foun­da­tion kindly sent us a copy of the great book Best of the Brain from Sci­en­tific Amer­i­can, a col­lec­tion of 21 superb arti­cles pub­lished pre­vi­ously in Sci­en­tific Amer­i­can mag­a­zine. A very nicely edited and illus­trated book, this is a must for any­one who enjoys learn­ing about the brain and spec­u­lat­ing about what the future will bring us.

Some essays, like the ones by Eric Kan­del (The New Sci­ence of Mind), Fred Gage (Brain, Repair Your­self), Carl Zim­mer (The Neu­ro­bi­ol­ogy of the Self) and that by Steven Hol­lon, Michael Thase and John Markowitz (Treat­ing Depres­sion: Pills or Talk), are both intel­lec­tual feasts and very rel­e­vant to brain fit­ness. And finally start­ing to per­co­late into main­stream consciousness.

Let me quote some quotes and reflec­tions as I was read­ing the book a cou­ple of days ago, in the court­yard of a beau­ti­ful French cafe in Berkeley:

1) On Brain Plas­tic­ity (the abil­ity of the brain to rewire itself), Fred Gage says: “Within the past 5 years, how­ever, neu­ro­sci­en­tists have dis­cov­ered that the brain does indeed change through­out life-…The new cells and con­nec­tions that we and oth­ers have doc­u­mented may pro­vide the extra capac­ity the brain requires for the vari­ety of chal­lenges that indi­vid­u­als face through­out life. Such plas­tic­ity offers a pos­si­ble mech­a­nism through which the brain might be induced to repair itself after injury or dis­ease. It might even open the prospect of enhanc­ing an already healthy brain’s power to think and abil­ity to feel”

2)  and How Expe­ri­ence affects Brain Struc­ture: Under the sec­tion title “A Brain Work­out”, Fred Gage says “One of the mot strik­ing aspects of neu­ro­ge­n­e­sis (Note: the cre­ation of new neu­rons) is that expe­ri­ence can reg­u­late the rate of cell divi­sion, the sur­vival of new­born neu­rons and their abil­ity to inte­grate into the exist­ing neural circuits…The best way to aug­ment brain func­tion might not involve drugs or cell implants but lifestyle changes.”

3) Biol­ogy of Mind: Eric Kan­del pro­vides a won­der­ful overview of the most inter­est­ing areas of cog­ni­tive neu­ro­science. Every stu­dent con­sid­er­ing a career in neu­ro­science should read that arti­cle (and his book In Search of Mem­ory). A great quote: “Since the 1980s the path toward merg­ing mind and brain research has become clearer. As a result, psy­chi­a­try has taken on a new role, both stim­u­lat­ing and ben­e­fit­ing from bio­log­i­cal thought. Dur­ing the past few years, even mem­bers of the psy­cho­an­a­lytic com­mu­nity have taken on a keen inter­est in the biol­ogy of mind, acknowl­edg­ing that every men­tal state is a brain state, that all men­tal dis­or­ders involve dis­or­ders of brain func­tion. Treat­ments work when they alter the brain’s struc­ture and functioning”.

4) And every inter­ven­tion works bet­ter when well-designed and well-directed. The arti­cle Treat­ing Depres­sion: Pills or Talk includes “Qui­etly over the years, newer psy­chother­a­peu­tic tech­niques have been intro­duced that may be just as good at alle­vi­at­ing acute dis­tress in all but the most severely depressed patients. And some of the ther­a­pies pro­vide advan­tages over med­ica­tion alone, such as improv­ing the qual­ity of rela­tion­ships or reduc­ing the risk that symp­toms will return after treat­ment is over)…most ther­a­pies blend cog­ni­tive and behav­ioral strate­gies and are often referred to as CBT. The goal is not to “think happy thoughts” but to become more accu­rate on one’s self-assessments and more effec­tive on one’s behav­iours. Recent vari­ants such as mindfulness-based cog­ni­tive ther­apy incor­po­rate strate­gies based on medi­a­tion and acceptance…”

5) An exam­ple on that bridge between mind and brain that Kan­del men­tions? Fred Gage reminds us how “Stim­u­lat­ing neu­ro­ge­n­e­sis could also lead to a new type of treat­ment for depres­sion. Chronic stress is believed to be the most impor­tant casual fac­tor in depres­sion aside from a genetic pre­dis­po­si­tion to the dis­or­der, and stress is known to restrict the num­ber of newly gen­er­ated neu­rons in the hip­pocam­pus (area of the brain involved in learn­ing and memory).”

6) New tech­nolo­gies: There are many great arti­cles on a vari­ety of tech­nolo­gies, from TMS (Tran­scra­nial Mag­netic Stim­u­la­tion) to implant­ing elec­trodes for patients with spe­cific dis­or­ders to neu­roimag­ing and “smart pills”.  Talk­ing about these, Stephen Hall says that “Given that we are most likely 5 or 10 years away from “see­ing what hap­pens”, we’re prob­a­bly des­tined to read a lot more about smart drugs before we actu­ally have any pills on hands”.

7) A reflec­tion on Intel­li­gence: Finally, there are a num­ber of men­tions of “intel­li­gence” in a very loosely defined way. Ray Kurzweil says “Some­time early in the next cen­tury, the intel­li­gence of machines will exceed that of humans”. In the arti­cle about “Unleash­ing Cre­ativ­ity”, Ulrich Kraft says “Intel­li­gence is not a cru­cial com­po­nent”. These 2 sen­tences only seem to make sense with a very nar­row, IQ-like, under­stand­ing of what “intel­li­gence” is. Maybe we need a Biol­ogy of Intel­li­gence, on top of the Biol­ogy of Mind?

Again, a very stim­u­lat­ing book. You can read more here. The Dana web­site also offers a list of rec­om­mended sci­en­tific books on the mind and brain.

If you are look­ing for a book with more prac­ti­cal advice, you may enjoy our review of The Dana Guide to Brain Health.

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