Omega-3 and omega-6 fatty acids found in cold-water fish may be helpful to long term brain health.Folic acid may also be helpful to both cognitive function and hearing.Ginkgo biloba and DHEA do not appear to help your brain.There is still more research to be done and never dismiss the placebo effect!Omega-3 fatty acids found in cold-water fish such as mackerel, herring, salmon, and tuna look more promising. Giuliano Fontani’s work at the University of Siena in Italy associated omega-3 supplementation with improved attentional and physiological functions, particularly those involving complex cortical processing.